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1.
Ann. hepatol ; Ann. hepatol;16(1): 86-93, Jan.-Feb. 2017. graf
Artigo em Inglês | LILACS | ID: biblio-838090

RESUMO

Abstract: Background and aims. Pegylated interferon (Peg-INF) and ribavirin (RBV) based therapy is suboptimal and poorly tolerated. We evaluated the safety, tolerability and efficacy of a 24-week course of sofosbuvir plus daclatasvir without ribavirin for the treatment of hepatitis C virus (HCV) recurrence after liver transplantation (LT) in both HCV-monoinfected and human immunodeficiency virus (HIV)-HCV coinfected patients. Material and methods. We retrospectively evaluated 22 consecutive adult LT recipients (16 monoinfected and 6 coinfected with HIV) who received a 24-week course of sofosbuvir plus daclatasvir treatment under an international compassionate access program. Results. Most patients were male (86%), with a median age of 58 years (r:58-81y). Median time from LT to treatment onset was 70 months (r: 20-116 m). HCV genotype 1b was the most frequent (45%), 55% had not responded to previous treatment with Peg-INF and RBV and 14% to regiments including first generation protease inhibitors. Fifty-six percent of the patients had histologically proven cirrhosis and 6 had ascites at baseline. All patients completed the 24-week treatment course without significant side effects except for one episode of severe bradicardya, with only minor adjustments in immunosuppressive treatment in some cases. Viral suppression was very rapid with undetectable HCV-RNA in all patients at 12 weeks. All 22 patients achieved a sustained virological response 12 weeks after treatment completion. Conclusion. The combination of sofosbuvir plus daclatasvir without ribavirin is a safe and effective treatment of HCV recurrence after LT in both monoinfected and HIV-coinfected patients, including those with decompensated cirrhosis.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Antivirais/administração & dosagem , Infecções por HIV/virologia , Transplante de Fígado/efeitos adversos , Hepatite C/tratamento farmacológico , Hepacivirus/efeitos dos fármacos , Doença Hepática Terminal/cirurgia , Coinfecção , Sofosbuvir/administração & dosagem , Imidazóis/administração & dosagem , Cirrose Hepática/tratamento farmacológico , Antivirais/efeitos adversos , Recidiva , Fatores de Tempo , Ativação Viral , RNA Viral/genética , Esquema de Medicação , Infecções por HIV/diagnóstico , Estudos Retrospectivos , Resultado do Tratamento , Hepatite C/diagnóstico , Hepatite C/virologia , Hepacivirus/genética , Hepacivirus/patogenicidade , Carga Viral , Quimioterapia Combinada , Ensaios de Uso Compassivo , Doença Hepática Terminal/diagnóstico , Doença Hepática Terminal/virologia , Sofosbuvir/efeitos adversos , Imidazóis/efeitos adversos , Imunossupressores/administração & dosagem , Cirrose Hepática/diagnóstico , Cirrose Hepática/virologia
2.
Ann Hepatol ; 16(1): 86-93, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28051797

RESUMO

 Background and aims. Pegylated interferon (Peg-INF) and ribavirin (RBV) based therapy is suboptimal and poorly tolerated. We evaluated the safety, tolerability and efficacy of a 24-week course of sofosbuvir plus daclatasvir without ribavirin for the treatment of hepatitis C virus (HCV) recurrence after liver transplantation (LT) in both HCV-monoinfected and human immunodeficiency virus (HIV)-HCV coinfected patients. MATERIAL AND METHODS: We retrospectively evaluated 22 consecutive adult LT recipients (16 monoinfected and 6 coinfected with HIV) who received a 24-week course of sofosbuvir plus daclatasvir treatment under an international compassionate access program. RESULTS: Most patients were male (86%), with a median age of 58 years (r:58-81y). Median time from LT to treatment onset was 70 months (r: 20-116 m). HCV genotype 1b was the most frequent (45%), 55% had not responded to previous treatment with Peg-INF and RBV and 14% to regiments including first generation protease inhibitors. Fifty-six percent of the patients had histologically proven cirrhosis and 6 had ascites at baseline. All patients completed the 24-week treatment course without significant side effects except for one episode of severe bradicardya, with only minor adjustments in immunosuppressive treatment in some cases. Viral suppression was very rapid with undetectable HCV-RNA in all patients at 12 weeks. All 22 patients achieved a sustained virological response 12 weeks after treatment completion. CONCLUSION: The combination of sofosbuvir plus daclatasvir without ribavirin is a safe and effective treatment of HCV recurrence after LT in both monoinfected and HIV-coinfected patients, including those with decompensated cirrhosis.


Assuntos
Antivirais/administração & dosagem , Coinfecção , Doença Hepática Terminal/cirurgia , Infecções por HIV/virologia , Hepacivirus/efeitos dos fármacos , Hepatite C/tratamento farmacológico , Imidazóis/administração & dosagem , Cirrose Hepática/tratamento farmacológico , Transplante de Fígado/efeitos adversos , Sofosbuvir/administração & dosagem , Ativação Viral , Idoso , Idoso de 80 Anos ou mais , Antivirais/efeitos adversos , Carbamatos , Ensaios de Uso Compassivo , Esquema de Medicação , Quimioterapia Combinada , Doença Hepática Terminal/diagnóstico , Doença Hepática Terminal/virologia , Feminino , Infecções por HIV/diagnóstico , Hepacivirus/genética , Hepacivirus/patogenicidade , Hepatite C/diagnóstico , Hepatite C/virologia , Humanos , Imidazóis/efeitos adversos , Imunossupressores/administração & dosagem , Cirrose Hepática/diagnóstico , Cirrose Hepática/virologia , Masculino , Pessoa de Meia-Idade , Pirrolidinas , RNA Viral/genética , Recidiva , Estudos Retrospectivos , Sofosbuvir/efeitos adversos , Fatores de Tempo , Resultado do Tratamento , Valina/análogos & derivados , Carga Viral
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