The validity of the static-charge-sensitive bed in the detection of fentanyl-induced respiratory depression.

BACKGROUND: Only a few methods for the measurement of breathing are non-invasive and do not interfere with measured parameters. The static-charge-sensitive bed (SCSB) could be such a monitor. The aim of this study was to evaluate the validity of the SCSB compared with the respiratory inductive plethysmograph (RIP) using a fentanyl-induced respiratory depression model. METHODS: Eight healthy male volunteers were infused with intravenous (i.v.) fentanyl (15 microg/kg/h) until a decrease in SpO2 below 90% for 1 min emerged. Breathing was continuously and simultaneously measured with SCSB and RIP. Oxygenation, hemodynamics, arterial blood gas analysis, and subjective opioid-related effects were monitored. Fentanyl concentration was measured from an arterial blood sample. The respiratory rate data of the SCSB (automated analysis and manual calculation) were compared with the corresponding RIP data, using analysis of variance for repeated measures. The validity of the SCSB compared with RIP was evaluated using an intra-class correlation coefficient. RESULTS: Mean fentanyl dose was 629 microg. A statistically significant association was found between the RIP and SCSB data in the manual SCSB analysis (P < 0.0001), but not in the automated SCSB analysis (P = 0.91). After adjusting for the effect of time and the SCSB method, an intra-class correlation coefficient between the manually calculated SCSB values and the RIP values was 0.66. CONCLUSION: Clinically significant changes in respiratory rate were detected with the SCSB, but the results had to be analyzed manually. The SCSB best suits situations, where comprehensive data are needed. It is not suitable for on-line respiratory monitoring, as the automated analysis did not calculate the respiratory rate correctly.

Postnatal adaptation after Caesarean section or vaginal delivery, studied with the static-charge-sensitive bed.

AIM: To compare postnatal adaptation between Caesarean and vaginal deliveries, by studying sleep states, oxygenation, heart rate and body movements. Another aim was to follow the adaptation of healthy, term, vaginally born babies. METHODS: Ten vaginally born and 12 neonates born by elective Caesarean section were recorded with a movement sensor (SCSB, static-charge-sensitive bed), electrocardiogram and oximeter. The recordings started 1.5 h after birth and lasted for 12 h. For the vaginal group, another 12 h recording was performed during the third night postpartum. RESULTS: Delivery mode did not affect sleep state distribution. The vaginal group had more oxyhaemoglobin desaturation episodes <95% than the Caesarean section group (mean +/- SD: 59 +/- 10% vs 42 +/- 22% of epochs, p = 0.03), especially in active sleep, but baseline saturation was similar (96 +/- 1% vs 95 +/- 3%, p = 0.93). The vaginal group had fewer movements during sleep than the Caesarean section group (movements of 5-10 s: 5 +/- 1 h(-1) vs 10 +/- 3 h(-1), p = 0.0001). During the first 3 d, the amount of sleeping and active sleep increased, whereas wakefulness and quiet sleep decreased. Baseline oxyhaemoglobin saturation and the number of movements of over 5 s increased. CONCLUSION: Delivery mode did not affect sleep state distribution but, unexpectedly, the vaginal group had more oxyhaemoglobin desaturation events and fewer body movements than the Caesarean section group. These differences during the first postnatal day remain unexplained, but they may reflect stress and pain during labour. After a few days, changes in sleep organization, and increases in oxyhaemoglobin saturation and frequency of body movements were noted in the vaginal group, which may represent recovery and adaptation to extrauterine life.

Treatment need for fixed metal ceramic bridge prostheses in patients treated by dental students in 1984-1996.

Even if implant therapy is very common nowadays, treatment with conventional fixed bridge prosthesis still has indications and cannot be forgotten. Because of improved dental health more teeth can be preserved and more fixed prostheses are prepared also for the elderly. The aim of this study was to discuss the future of treatment need in fixed metal ceramic bridge prostheses based on the analysis of distribution of pontics in dentition in four different age groups during the years 1984-1996. Data were collected from the patient files. The numbers of upper lateral incisors, upper first premolars and lower first molars were analysed in years 1984-1987, 1988-1992 and 1993-1996 between and within age groups of under 34, 35-49, 50-64 years and over 65 years. As a conclusion, in the future the treatment need for fixed bridge prostheses will be highest among patients over 50 years and their most replaced teeth are, besides lower first molars, the upper first premolars.

Fetal oxygen saturation during epidural and paracervical analgesia.

BACKGROUND: We wanted to assess changes in fetal oxygenation during maternal epidural or paracervical analgesia in labor. METHODS: A prospective, open and non-randomized study. Twenty healthy parturients were enrolled before they asked for pain relief. Informed consent was obtained. Fetal and maternal oxygen saturations were measured before and up to 1 h after the initiation of analgesia. Fetal oximetry was performed with the Nellcor N-400 oximeter+FS-14B fetal oxygen sensor (Nellcor Puritan Bennett, Pleasanton, California, USA). Maternal oximetry was done with Datex Satlite portable monitor (Datex, Finland). Visual analog scale was used for assessing pain relief. Two-way analysis of variance and students t-test were used for statistical analyses. RESULTS: Fetal oxygenation initially improved in both groups. The saturation then returned to baseline in both groups. In the epidural group, the values remained at baseline or slightly below, while in the paracervical group the saturation remained a little higher than baseline (p=0.009). No change was seen in maternal oxygenation or heart rate. No change in fetal heart rate was found either. Epidural block was superior to paracervical block with respect to pain relief (p=0.002). CONCLUSIONS: There was a small but significant difference in fetal oxygenation between epidural and paracervical groups during the observation period. The magnitude of the difference is hardly clinically significant. A larger, randomized study is needed to elucidate the mechanisms behind this finding.

Influence of previous restoration of the tooth on prognosis of crowns with dowels.

Due to extensive loss of tooth substance the restoration of endodontically treated tooth requires intracanal dowels to give an efficient strength for the crown. The aim of our study was to investigate whether the previous type of restoration of the tooth, i.e. composite restoration with screw post versus one-piece dowel crown, has an effect on the prognosis of crowns with dowels. The material consisted of 111 single crowns and as a previous restoration there were 83 composite restorations with screw posts and 28 one-piece dowel crowns. The mean follow-up time was 78 months (range 6--163 months). The cumulative survival was 87% for one-piece dowel crowns and 84% for composite resins with screw posts. There were six root fractures, four losses of cement retention and one tooth extraction due to caries in crowns with previous composite resin with screw posts. In one-piece dowel crowns as a previous restoration there were two root fractures and one tooth extraction for periodontal reasons. In conclusion, it seems that the previous restoration has no marked effect on the prognosis of crowns with dowels when studying a composite resin restoration with screw post and a one-piece dowel crown.

Neonatal monitoring after maternal fentanyl analgesia in labor.

OBJECTIVE: To characterize different methods of monitoring neonatal effects associated with maternal opioid analgesia. Special focus was on the static-charge-sensitive bed (SCSB), which could potentially serve as a non-invasive neonatal monitor. METHODS: 12 healthy, term newborns from normal pregnancies were included in this prospective, randomized, controlled study. Maternal labor analgesia was either intravenous fentanyl (n = 5) or paracervical bupivacaine blockade (n = 7). Neonatal recording from delivery to the age of 12 hours included continuous SCSB monitoring with ECG and oximeter for sleep states, respiration, oxygenation, heart rate, and body movements. In addition, umbilical blood pH, Apgar, Amiel-Tison's Neurologic and Adaptive Capacity Scoring (NACS), skin cyanosis scoring, blood pressure, rectal and skin temperatures, and skin blood flow measurements were performed. RESULTS: The study was interrupted, because one baby in the fentanyl group had a significant decrease in oxyhemoglobin saturation (SpO2) to 59%. This was considcred to be residual effect of fentanyl and was treated with naloxone. SpO2 was generally lower in the fentanyl group. Epochs with SpO2 < 90% were more frequent in the fentanyl group, especially during active sleep (mean +/- SD 11.9 +/- 10.7% vs. 2.0 +/- 1.7% of epochs, p = 0.034). Mean heart rate values were lower in the fentanyl group (121.1 +/- 6.4 vs. 132.6 +/- 6.8 beats per minute, p = 0.02), and this difference was seen during wake and all sleep states. Maximum heart rate values were lower in the fentanyl group, too. The opiate group had less quiet sleep than controls (9.6 +/- 2.8% vs. 18.3 +/- 8.3%, p = 0.05). NACS after birth was lower in the fentanyl group (median [range] 15 [13-26] vs. 22 [20-25], p = 0.004). CONCLUSIONS: Several differences were seen between the fentanyl and the control group babies. The SCSB method proved sensitive enough to find neonatal effects of maternal analgesia. Together with ECG and SpO2 monitoring, SCSB gives plentiful information on neonatal well-being in a non-invasive way. Results of this study emphasize the importance of neonatal monitoring after maternal opiate use in labor.

Effect of edentulousness on mandibular size and condyle-fossa position.

Modern imaging methods make possible the more precise examination of the complicated bony structure of the temporomandibular joint (TMJ) and the performance of cephalometric analysis. The aim of our study was to analyse the effect of edentulousness on the mandibular size and the condyle-fossa position using roentgencephalograms and axial computed tomography (CT) scans. The study group consisted of 20 edentulous patients (14 women, six men, mean age 60 years) whose mean period of edentulousness was 20 years (range 3-34 years). A CT examination of their TMJs was performed and roentgen-cephalograms in 16 of this group were taken after prosthetic treatment. Sixteen dental students were chosen according to sex as controls. Earlier CT scans of 49 dentate subjects of both sexes were used as controls for the analysis of bicondylar asymmetry. The position of the glenoid fossa was more anterior in edentulous subjects than in dentate ones and its anterior position correlated significantly (P < 0.02) with the period of edentulousness, a finding which has not been confirmed before. It can be concluded that the fossa is a remodelling unit as a part of the functional entity when the function is altered dramatically as in the case of edentulous patients.

A 10-year follow-up study of fixed metal ceramic prosthodontics.

The aim of this retrospective study was to record patients' satisfaction with fixed metal ceramic bridges and crowns made by dental students and to evaluate the functioning and condition of the bridges and crowns clinically and radiologically. Out of the 60 patients treated at the Institute of Dentistry during 1984-85, 30 patients attended the follow-up examination (16 women, mean age 39, range 23-62 years and 14 men, mean age 44, range 26-65 years). The anamnestic data and data regarding treatment procedures were collected from the patient files. The patients had been supplied with 41 crowns and 24 bridges (mean 3.9 units, range 3-6 units), which included 61 abutments and 33 pontics or cantilever extensions (abutment/pontic ratio 1.85: 1). Marginal fidelity was unsatisfactory in 13% of the crowns and bridges and gingival bleeding and pockets of 4-6 mm were noted in 27% and 12% of cases, respectively. None of the subjects had caries in the abutments.

Gonial angles and condylar and ramus height of the mandible in complete denture wearers--a panoramic radiograph study.

It has been accepted that the shape of the mandibular base, and especially the gonial angle of the mandible, correlates with the function of the jaw closing muscles. The gonial angles of the mandible and condylar and ramus heights of 30 complete denture wearers (18 women, 12 men, mean age 61 years, range 42-74 years) coming for renewal of their dentures were measured using panoramic radiographs. The mean period of edentulousness was 26 years (range 10-53 years). No statistically significant difference was observed between the sexes in the the sizes of gonial angles and condylar and ramus heights. The right gonial angle was statistically significantly smaller than the left one and correlated negatively with the ramus height in both sides but positively with the increased EMG activity in the right masseter muscle. The size of the gonial angle and the condylar and ramus heights did not correlate with the age of the patients, edentulous period or alveolar ridge resorption.

Effect of complete denture renewal on oral health--a survey of 42 patients.

The effect of complete denture renewal on oral health was evaluated both subjectively and clinically at follow-up 30 months (range 19-36 months) after completion of treatment in 42 edentulous patients (31 women and 11 men, aged 34-76 years) treated by dental students during 1989-1992. Ninety per cent of the patients were satisfied with the new appearance of their dentures and 71% with the way they functioned. When comparing the base data and results from follow-up it seems that general health and medication, anatomical circumstances, salivary flow rates and denture wearing habits in edentulous subjects do not change significantly over a few years. The main effects of denture renewal are seen in patient satisfaction, and clinically in the improved condition of oral mucosa and better fit and acceptable occlusion of dentures.

Factors related to Periotest values in endosseal implants: a 9-year follow-up.

Periotest values (PTV) of successful endosseal implants of 2 one-stage implant systems. TPS and ITI, were followed from 3 months to 9 years in order to determine the factors that contribute to the values. 128 TPS screw implants were inserted in the lower jaw of 34 subjects, (mean age 55 years), for retaining overdentures. 108 ITI implants were inserted in the upper and lower jaws in 50 subjects (mean age 42 years), for retaining overdentures, crowns and bridges. PTVs were first measured after the osseointegration period and thereafter annually. First of all there was a difference between the 2 implant systems. Mean PTVs of TPS bicortical screws were significantly lower (P < 0.05) than those of ITI implants (screws, hollow-screws, hollow-cylinders). Factors which significantly contributed to PTVs of ITI implants were jaw (upper/lower), implant length and region of the jaw in which the implant was inserted. PTVs of ITI implants in the lower jaw were lower than in the upper jaw (P < 0.05). The length of implant had no effect on PTVs in the lower jaw, but in the upper jaw, PTVs of ITI 8-10-mm implants were lower than 12-mm implants (P < 0.05). PTVs of implants inserted in the anterior region of the upper jaw were higher than those in the posterior region (P < 0.05). In conclusion, bone quality and implant length had a statistically significant effect on implant mobility in long-term follow-up. PTVs of various implant systems, however, differ, a fact that must be taken into account in evaluating the success of implants.

Influence of complete denture renewal on craniomandibular disorders: a 1-year follow-up study.

Great individual variation in the signs and symptoms of craniomandibular disorders (CMD) and in the adaptability of the masticatory system is evident among complete denture wearers. The masticatory system of 64 edentulous patients (41 women, 23 men; mean age 59 years, range 41-80 years), who came to the Institute of Dentistry for renewal of their complete dentures, was examined before prosthetic treatment and after a 1-year follow-up period. The degree of CMD was assessed using the anamnestic and clinical dysfunction indices of Helkimo. The results show that few complete denture wearers had severe signs and symptoms of CMD. No statistically significant correlation was noted between CMD and either the duration of edentulousness or the number of sets of dentures.

Intravenous fentanyl PCA during labour.

PURPOSE: To evaluate the usefulness of intravenous patient-controlled analgesia (PCA) fentanyl for labour analgesia, its effectiveness for maternal pain and safety for the fetus and newborn. METHODS: Twenty primigravidas were randomised to receive intravenous PCA fentanyl or epidural analgesia for labour pain. Maternal pain, heart rate and arterial oxyhaemoglobin saturation (SpO2) were monitored. Fetal and neonatal monitoring included cardiotocogram (CTG), APGAR, neurological scoring and static-charge-sensitive bed (SCSB) recording for 12 hr postnatally with ECG and SpO2. Fentanyl concentrations and pH of umbilical artery and vein were analysed. RESULTS: Initially, epidural analgesia was more effective (P = 0.01), and three patients in the fentanyl group were given epidural due to unsatisfactory pain relief. Overall satisfaction for analgesia did not differ between the groups. Maternal side-effects were more frequent in the fentanyl group (dizziness and tiredness most often, P = 0.0001). Severe side-effects were not reported. In CTG there were no differences between groups. All the newborns were healthy, APGAR and pH were normal. Naloxone was not used. Neurological scoring was similar in both groups. In 12 hr monitoring heart rate, breathing frequency and movement time were similar in both groups, but SpO2 was lower in the fentanyl group (P < 0.001). Umbilical cord fentanyl concentrations were low or beyond the detection limit. CONCLUSION: Intravenous fentanyl can be used for labour analgesia with the doses reported here as an alternative to epidural analgesia. However, the fetus and neonate must be appropriately monitored. Naloxone and oxygen should be available if neonatal distress occurs.

The effect of stomatognathic treatment: a clinical follow-up study.

Temporomandibular disorders (TMD) are common but complex problems in dentistry. Most patients can be treated using relatively simple methods, such as counselling, splint therapy, and occlusal adjustment. Patients who do not respond to conservative treatment may benefit from surgical treatment. Ninety-two patients (68 women, 24 men, mean age 36 years, range 14-74 years) were treated between 1988 and 1990 in the Department of Prosthetic Dentistry and Stomatognathic Physiology. Sixty-two patients of which 15 were surgically treated, attended for clinical follow-up in 1994. Success of treatment was evaluated using the anamnestic and clinical dysfunction indices of Helkimo. All patients reported that they had benefitted from their treatment. Symptoms of TMD were also noted to be clinically less than before. The results of the study reported show that the effects of stomatognathic treatment are beneficial in long-term, i.e. the patients were subjectively satisfied, and symptoms recorded clinically on follow-up were statistically significantly less than before.

The sedative and sympatholytic effects of oral tizanidine in healthy volunteers.

Tizanidine, an imidazoline derivative with alpha 2-receptor-mediated central muscle relaxant activity, is in widespread clinical use for the treatment of spasticity. To evaluate its possible role in anesthesia we assessed the sedative and sympatholytic effects of orally administered tizanidine in a double-blind, placebo-controlled, randomized, cross-over study in six healthy male volunteers. Three different doses of tizanidine (4, 8, and 12 mg) were tested and compared to clonidine 150 micrograms. The sedative and sympatholytic effects of tizanidine 12 mg were comparable in magnitude to those of clonidine 150 micrograms, but the effects of clonidine were longer lasting. Similarly, the observed decreases in arterial blood pressure (diastolic, 13% and 19%; systolic, 10% and 8% for tizanidine and clonidine, respectively) and salivation were comparable in magnitude but of shorter duration after tizanidine 12 mg than after clonidine. Clonidine and tizanidine 12 mg had also similar effects on the secretion of growth hormone. Our results indicate that the effects of a single 12-mg oral dose of tizanidine resemble those of 150 micrograms oral clonidine, but are of shorter duration. Tizanidine may thus be a useful alternative to clonidine as an orally active, short-acting alpha 2-adrenoceptor agonist in the perioperative period.

Effect of treatment of palatal inflammatory papillary hyperplasia with local and systemic antifungal agents accompanied by renewal of complete dentures.

The aim of this study was to estimate the effect of local and systemic antifungal treatment, accompanied by renewal of complete dentures, on palatal inflammatory papillary hyperplasia (PIPH). The treatment groups consisted of 26 subjects treated with a local antifungal agent (miconazole, 2% gel) for 4 weeks and 13 subjects treated with a systemic antifungal agent (fluconazole, 50 mg) for 2 weeks (test groups). Ten subjects fitted with new complete dentures served as a control group. Variables examined before antifungal and prosthetic treatment included estimation of the size and color of the affected palatal area, measurements of the lengths of the papillae, and salivary variables. Six months after the completion of prosthetic treatment healing was determined as disappearance or marked reduction of the redness of the PIPH. Healing was more often observed in test groups (64%) than in the control group (20%) (p = 0.012). Fifty-eight per cent of the subjects treated with a local (miconazole, 2%) and 77% of those treated with a systemic (fluconazole, 50 mg) antifungal agent were healed. Even though papillary hyperplastic tissue did not disappear, the treatment of PIPH with an antifungal agent without surgery before renewal of dentures might be an alternative treatment in mild cases.

Evaluation of masticatory muscles of edentulous patients by computed tomography and electromyography.

On account of its tissue resolution capacity, computed tomography (CT) is an excellent method for the examination and quantitative analysis of the masticatory muscles. The aim of the present study was to evaluate the influence of the long edentulous period by CT on the structure of the main masticatory muscles in 10 edentulous patients and to study their functioning by electromyography (EMG) in connection with the renewal of the dentures. CT scanning was performed before prosthodontic treatment and EMG recordings of the masseter and temporal muscles before treatment and 4 weeks and 6 months after insertion of the new dentures. The results suggest, however, that a long edentulous period is visible not only in the functioning of the masticatory muscles, in terms of decreased EMG activity, but also as decreased density of the muscles which implies muscle atrophy, as seen by CT in the masseter and medial pterygoid muscles.

Changes in head and cervical-spine postures and EMG activities of masticatory muscles following treatment with complete upper and partial lower denture.

A clinical stomatognathic, cephalometric and electromyographic (EMG) study was performed in relation to 14 subjects (10 women, 4 men), each with an edentulous maxilla and residual mandibular dentition before and six months after treatment with complete upper and partial lower dentures. The mean age of the subjects was 54.4 years (range 43-64 years). The mean period of edentulousness and age of dentures were 22.5 years (range 15-33 years) and 14.1 (range 1.5-30 years), respectively. Natural head position was recorded (using a fluid-level method) and measured from cephalograms. EMG activity was measured in relation to masseter and temporal muscles. A decrease in clinical dysfunction index was noted in 12 of 14 subjects (86%). There was no change in cervical inclination, but a slight extension of the head was noted after treatment. Rapid recovery of the masticatory muscles was reflected in increased EMG activity, especially when biting in the maximal intercuspal position. In cases of edentulous maxilla and residual mandibular anterior dentition, treatment with a complete upper and lower partial denture had a favorable effect on craniomandibular disorders and masticatory-muscle function.

Assessment of states of dentures and interest in implant-retained prosthetic treatment in 55-year-old edentulous Finns.

One hundred and fifty 55-year-old edentulous subjects (104 women and 46 men) were interviewed. Materials, conditions, functional stabilities, and occlusions of complete dentures, and resorption of alveolar crests were recorded and assessed. The dentures were in good condition in 52% of subjects. Occlusion was correct in 45% of cases. Every fifth mandibular denture exhibited good functional stability. The mean age of dentures in good condition and functionally stable was statistically significantly lower than the mean age of dentures poor in these respects. Severe alveolar resorption contributed to poor functional stability of dentures (P = 0.0068 (maxilla), P = 0.0023 (mandible)) and to incorrect occlusion (P = 0.0177). Good agreement was noted between objective and subjective opinions of denture function (P = 0.01 (maxillary denture), P = 0.01 (mandibular denture)). Although oral rehabilitation with endosseous implants is common and, objectively, needs for such treatment existed, only 22 subjects (15%) who had recently had their dentures renewed and were experiencing problems with functional stability were interested in implant-retained overdentures.

Clinical and radiologic assessment of possibilities for endosseous implants and osseointegrated prostheses in 55-year-old edentulous subjects.

To determine how many 55-year-old edentulous subjects were suitable candidates for implant-retained overdentures of fixed implant bridges and how many of them might be interested in such treatment, case histories were reviewed, and clinical and radiologic examinations were performed on 146 subjects (100 women, 46 men) in a medium-sized city in northern Finland. Numbers and lengths of implants required in altogether 16 regions in the upper and lower jaw were evaluated. The commonest implant length was 8 mm in the upper jaw and 16 mm in the lower jaw. Construction of an implant-retained fixed bridge would have been possible in the upper jaw in 121 subjects (83%) and of an overdenture in all lower jaws. Information about the benefits of the treatment is important because, although the percentage of subjects who were suitable candidates for implant-retained prostheses was high, few subjects were aware of or interested in this type of treatment.