RESUMO
This review highlights literature data on potential genetic markers that potentially influence the development of postoperative cognitive dysfunction, such as TOMM40, APOE, TREM2, METTL3, PGC1a, HMGB1 and ERMN. The main pathogenetic mechanisms triggered by these genes and leading to the development of cognitive impairment after anesthesia are described. The paper systematizes previously published works that provide evidence of the impact of specific genetic variants on the development of postoperative cognitive dysfunction.
Assuntos
Apolipoproteínas E , Proteínas do Complexo de Importação de Proteína Precursora Mitocondrial , Complicações Cognitivas Pós-Operatórias , Receptores Imunológicos , Humanos , Complicações Cognitivas Pós-Operatórias/genética , Apolipoproteínas E/genética , Metiltransferases/genética , Glicoproteínas de Membrana/genética , Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética , Proteínas de Membrana Transportadoras/genética , Marcadores Genéticos , Proteína Reelina , Disfunção Cognitiva/genética , Disfunção Cognitiva/etiologia , Predisposição Genética para DoençaRESUMO
The review of the literature highlights current studies proving the relationship between cognitive impairment and various types of myocardial remodeling. The main pathophysiological mechanisms of development of concentric and eccentric myocardial hypertrophy and their influence on the formation of cognitive impairments are described. Direct causal relationships have not yet been found, but several linking factors in the development of cognitive impairment and myocardial remodeling are being investigated: arterial hypertension, increased arterial stiffness, endothelial dysfunction, microglial activation, hyperreactivity of the sympathetic nervous system, and obesity.
