[Blood biomarkers of early diagnosis for neonatal bacterial infections: back from Senegal cohort]. / Biomarqueurs sanguins du diagnostic précoce des infections néonatales bactériennes : retour d'expérience d'une cohorte sénégalaise.

In Senegal, reducing neonatal mortality remains a challenge. The management of neonatal infections remains problematic and presents a strong clinical focus. Indeed, like all developing countries, the difficulty of acquiring state-of-the-art infrastructure and the financial cost impact on the routine use of biomarkers. It is in this context that we conducted this study to identify the best biological strategy for making a reliable diagnosis. Ninety-nine newborns were recruited at the pediatric service of the Diamniadio Children's Hospital (Senegal). CRP was assayed by latex immuno-agglutination method, IL-6 and IL-8 using Luminex® technology, PCT by chemiluminescence, orosomucoid by immunoturbidimetry and SAA by ELISA technique. 20 newborns had probable infection and six established infection. Deaths and complications were significantly greater in these groups. With an optimal decision threshold of 16.3 mg/L, CRP performed better (compared to the other tested blood biomarkers) with AUC, sensitivity and specificity of 94%, 88% and 99%, respectively. With the performance obtained from CRP in the diagnosis of neonatal bacterial infections, the installation of panels with other biomarkers with advanced and expensive technology is not necessary. Thus, optimal care and within a reasonable timeframe can be done in our health facilities, with this accessible marker that is CRP.

[Prevalence of dyslipemia in Aristide le Dantec biochemistry laboratory in Dakar Senegal]. / Prévalence des dyslipidémies au laboratoire de biochimie du CHU Aristide le Dantec de Dakar, Sénégal.

INTRODUCTION: This study aims to evaluate the prevalence of dyslipidemias among patients who underwent assay of a lipid parameter at the Laboratory of Biochemistry of Aristide Le Dantec University Hospital in 2013. METHODS: We conducted a retrospective study of 1356 patients between ages 10-94 years presenting at the laboratory of Biochemistry of CHU Le Dantec from January to December 2013. All patients who had undergone at least one lipid assay whose results were recorded in the laboratory register were enrolled in the study. Total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides were measured using enzymatic methods (Cobas Integra 400 plus biochemistry analyzer - Roche Diagnostics). RESULTS: The prevalence of dyslipidemia in our study population was 39.30%. The prevalence of hypercholesterolemia, hypo-HDL-cholesterolemia, hyper-HDL-cholesterolemia, hypertriglyceridemia, mixed hyperlipidemia was 30,89% ; 7,30% ; 31,19% ; 0,51% ; 7,22% respectively. The subjects aged 40 to 59 years appeared to be more exposed. Moreover, there was a female predominance in hypercholesterolemia (54.17% vs 45.82%) the hypocholesterolemia (54.54% vs45,45%), and mixed hyperlipidemia (51.08% vs 48.97%). Dyslipidemias were strongly correlated to hypertension and obesity. CONCLUSION: The high prevalence of dyslipidemias found in our study highlights the importance of studying the prevalence of cardiovascular risk factors, in particular dyslipidemias, in Senegalese population.