[Role of carboxypeptidase in regulation of fibrinolysis].

The paper is devoted to analysis of the literature data about a recently described component of haemostasis system that posseses carboxypeptidase activity and is activated by thrombin. The history of investigation and isolation of the new carboxypeptidase, their properties and participation in inhibition of fibrinolysis reactions was considered. Data are cited about carboxypeptidase B level changes under different physiological conditions and possible methods of fibrinolysis reactions strengthening by means of influence on activity of that carboxypeptidase.

[Activity of Ca(2+)-dependent neutral proteinases in rat organs under cobalt and mercury chloride injection]. / Aktivnost' Ca(2+)-zavisimykh neitral'nykh proteinaz v organakh krys pri vvedenii im khloridov kobal'ta i rtuti.

The activity of Ca(2+)-dependent neutral proteinases in rats under cobalt and mercury chloride injection was investigated. The calpains activity increase in the lungs, heart, liver and kidneys was revealed after 2 h cobalt chloride action. The mercury chloride gives a reliable increase of calcium-dependent neutral proteinases only in the kidneys.

[Proteinase-proteinase inhibitor system in aged rats with stimulated hypertension exposed to cord blood]. / Sistema proteinaza-ingibitor proteinaz u starykh krys so stimulirovannoi gipertenziei pod vliianiem kordovoi krovi.

The proteinases, nontrypsinlike proteinases (NTLP), alpha-1-proteinase inhibitor, alpha-2-macroglobulin (alpha-2-MG) activities were researched in serum, tissues of hypothalamus, cerebral cortices, lung, heart, liver, kidneys in old rats with hypertension caused by electricity current at introduction of cord and mature blood preparations. The increase of proteinase and NTLP activities were revealed on the background of alpha-2-MG level reduction. The changes caused by stimulated hypertension, can be corrected by introduction of blood preparations and the effect of cord blood is more manifested.

[Effect of quercetin on some indicators of the proteinase-proteinase inhibitor system in rats upon administration of cobalt chloride to them]. / Vliianie kvertsetina na nekotorye pokazateli sistemy proteinaza-ingibitor proteinaz u krys pri vvedenii im khlorida kobal'ta.

The results of quercetin effect on some changes of proteinase--proteinase inhibitor system parameters in rats under cobalt chloride injection are shown. It was established that preliminary quercetin administration prevened neutral proteinase activation and alpha-2-macroglobulin activity decreasing after 2 h of cobalt chloride influence.

[Chymase, tonin and elastase in rat tissue under oxidative stress caused by administering cobalt chloride]. / Khimaza, tonin i élastaza v tkaniakh krys pri okislitel'nom stresse, vyzvannom vvedeniem khlorida kobal'ta.

Character of chymase, tonin and elastase activities changes in rats heart, lungs, liver, kidney under the oxidative stress, induced by cobalt chloride, was investigated. The elastase activity increase in the researched organs and all proteinase indicated in liver were revealed. The specific effect of tonin involvement in injuring effect of cobalt chloride in rat heart is shown, this effect is revealed by local absence of chymase level change, that is determined by its species unsimilarity compare with human. The conclusion about more essential significance of elastase and chymase in injuring effect in lungs and kidneys tissues is made.

[Effect of pentoxyphylline on certain indicators of the proteinase-proteinase inhibitor system in rats upon administration of cycloheximide]. / Vliianie pentoksifillina na nekotorye pokazateli sistemy proteinaza-ingibitor proteinaz u krys pri vvedenii im tsiklogeksimida.

The pentoxifylline influence on neutral proteinase, alpha-2-macroglobulin, trypsin-alpha-1-proteinase inhibitor and elastaseinhibitory activity under cycloheximide injection has been investigated. Two hours after cycloheximide injection the activity of neutral proteinases increases in rats serum, lungs, heart, liver and kidneys. The preliminary injection of pentoxifylline prevents increase of neutral proteinases activity. Cycloheximide also decreases alpha-2-macroglobulin activity in serum and liver and trypsin-, elastaseinhibitory activity of alpha-1-proteinase inhibitor in all investigated organs. At using pentoxifylline the alpha-2-macroglobulin activity doesn't change in liver and increases in serum in comparison with only cycloheximide and there are no observed any alpha-1 inhibitor proteinase activity changes in rats serum and organs.

[Proteinase-proteinase inhibitor complex in rats under oxidative stress caused by administration of cobalt chloride]. / Sistema proteinaza-ingibitor proteinaz u krys pri oksidativnom stresse,vyzvannom vvedeniem khlorida kobal'ta.

Mechanisms of proteinase-inhibitor proteinase system response was estimated following of cobalt chloride injection. The increase proteinase activity, which led to significant decrease of alpha-2-macroglobulin (alpha-2-MG) level was established that indicated to the removal of the proteinase in complex with alpha-2-MG from the organism. Increase of alpha-1-proteinase inhibitor (alpha-1-PI) trypsin-inhibitory activity in the kidneys testify about removal of oxidative alpha-1-PI.