Assuntos
Psoríase , Humanos , Doença Aguda , Causalidade , Doença Crônica , Psoríase/epidemiologia , Psoríase/genética , Pirina/genéticaRESUMO
Here, we report an 86-year-old Japanese woman presenting with confluent maculopapular erythema, which developed following the second dose of COVID-19 Messenger RNA (mRNA) vaccine (BNT162b2). Her skin lesions spread over time and persisted for more than 3 months. Surprisingly, immunohistochemical staining of the lesion 100 days after the disease onset revealed the COVID-19 spike protein expressed by vascular endothelial cells and eccrine glands in the deep dermis. As she had no episode of COVID-19 infection, it is highly likely that the spike protein was derived from the mRNA vaccine and it might be the cause of the development and persistence of her skin lesions. Her symptoms were prolonged and intractable until oral prednisolone was given.
Assuntos
COVID-19 , Glândulas Écrinas , Humanos , Feminino , Idoso de 80 Anos ou mais , Células Endoteliais , Vacina BNT162 , Glicoproteína da Espícula de Coronavírus , Vacinação , Vacinas contra COVID-19/efeitos adversos , RNA Mensageiro , Eritema/etiologia , DermeAssuntos
COVID-19 , Úlcera Cutânea , Vacina BNT162 , Vacinas contra COVID-19 , Humanos , RNA Mensageiro , SARS-CoV-2 , Úlcera Cutânea/etiologiaAssuntos
Vacinas contra COVID-19/efeitos adversos , COVID-19/prevenção & controle , Toxidermias/diagnóstico , Exantema/diagnóstico , SARS-CoV-2/imunologia , Administração Oral , Vacina BNT162 , Biópsia , COVID-19/complicações , COVID-19/diagnóstico , COVID-19/virologia , Diagnóstico Diferencial , Toxidermias/tratamento farmacológico , Toxidermias/imunologia , Toxidermias/patologia , Exantema/tratamento farmacológico , Exantema/imunologia , Exantema/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Prednisolona/administração & dosagem , SARS-CoV-2/genética , Pele/imunologia , Pele/patologiaRESUMO
Pralatrexate has been approved for the treatment of relapsed/refractory peripheral T cell lymphomas. Studies in the U.S. also support the clinical efficacy of pralatrexate to treat advanced-stage cutaneous T-cell lymphomas, but outcomes in Japanese patients have not yet been reported. We herein describe two Japanese patients with heavily-pretreated relapsed/refractory mycosis fungoides that were successfully controlled by pralatrexate.