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1.
Nutr. hosp ; 31(5): 2147-2153, mayo 2015. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-140383

RESUMO

Introduction: The role of the fatty acid in the prevention or progression of chronic diseases has generated significant interest on the part of researchers. Thus, our objective was to evaluate the long-term effects of high-fat diet containing soybean or canola oil on body development and bone parameters of male rats. Methods: After weaning, rats were grouped and fed either a control diet (7S) or a high-fat diet containing soybean (19S) or canola oil (19C). Femur and lumbar vertebra (LV4) structure were determined at 180 days by dual-energy X-ray absorptiometry and computed tomography. Results: The groups showed similar food intake, body mass and length development. The bone parameters of the 19C were similar to the control group, while the 19S showed lower bone parameters when compared to the other groups. Conclusions: The high-fat diet containing soybean oil was unfavorable to bone structure, while the canola oil contributed bone health during the adult stage of life (AU)


Introducción: El papel del ácido graso en la prevención o la progresión de las enfermedades crónicas ha generado un interés significativo por parte de los investigadores. Por lo tanto, nuestro objetivo fue evaluar los efectos a largo plazo de la dieta alta en grasas que contienen soja o aceite de canola en los parámetros de desarrollo del cuerpo y los huesos de ratas macho. Métodos: Después del destete, las ratas se agruparon y se alimentaron con una dieta control (7S) o una dieta alta en grasa que contiene soja (19S) o aceite de canola (19C). Fémur y vértebras lumbares (LV4) estructura se determinaron a los 180 días por absorciometría dual de rayos X y tomografía computarizada. Resultados: Los grupos mostraron similares ingesta de alimentos, la masa corporal y el desarrollo de longitud. Los parámetros óseos de la 19C fueron similares al grupo control, mientras que los 19S mostró parámetros óseos inferiores en comparación con los otros grupos. Conclusiones: La dieta alta en grasas que contiene aceite de soja fue desfavorable a la estructura ósea, mientras que el aceite de canola contribuyó salud de los huesos en la etapa adulta de la vida (AU)


Assuntos
Animais , Ratos , Dieta Hiperlipídica , Óleos de Plantas/farmacocinética , Densidade Óssea , Composição Corporal , Ratos/crescimento & desenvolvimento , Óleo de Soja/efeitos adversos , Estudos de Casos e Controles , Desenvolvimento Ósseo , Densitometria
2.
Nutr. hosp ; 29(2): 370-375, 2014. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-120597

RESUMO

Introduction: Diabetic patients have a higher risk to osteoporotic fractures. Foods, such as yam, to oppose hyperglycemia, has been used to treatment of diabetes. Objective: The goal was assess the role of Brazilian yam (Dioscorea bulbifera) on glycemia and bone parameters of female diabetic rats. Methods: Female Wistar rats with 3 months age were allocated in three groups. Control group (C, n = 6),treated with normal fat diet. Diabetic rats treated withhigh-fat diet without (DM, n = 8) and with (DMY, n = 8) liofilized yam flour. After 5 weeks of the experiment, serum glucose and insulin, pancreas mass, number and area of pancreas islets were quantified. And femur parameters were analyzed by dual-energy X-ray absorptiometry(DXA) and computed tomography (CT).Results: Differences were considered significant ifP<0.05. Diabetic groups showed lower (P < 0.05): femur and pancreas mass, area of the pancreatic islets and insulin. However, DMY showed lower (-10%, P < 0.05)concentrations of glucose to DM group. Femur, by DXA, showed lower bone mineral density, content and area in the DM group. While the DMY group showed greater(+27%, P < 0.05) radiodensity of femoral head when compared to DM group. Discussion: Brazilian yam flour supplement did not fix a defect, but alleviated the consequences of the experimental diabetic disease. It showed results to control the rise in blood glucose levels in diabetic rats, suggesting protection in oxidative agents and postpone harm in the bone. Conclusion: Considering all the findings of the present study, our results suggest that yam flour does act producing benefits in the experimental diabetes (AU)


Introducción: Los pacientes diabéticos tienen un mayor riesgo de fracturas osteoporóticas. Los alimentos, como el ñame, para oponerse a la hiperglucemia, se ha utilizado para el tratamiento de la diabetes. Objetivos: El objetivo era evaluar el papel de ñame brasileño(Dioscorea bulbifera) sobre la glucemia y el hueso parámetros de ratas diabéticas hembra. Métodos: Ratas Wistar hembra con 3 meses de edad fueron asignados en tres grupos. El grupo de control (C, n= 6), tratados con dieta normal de la grasa. Las ratas diabéticas tratadas con dieta alta en grasas y sin (DM, n = 8)y con (DMY, n = 8) harina de ñame liofilizado. Después se cuantificaron 5 semanas del experimento, la glucosa y la insulina en suero, la masa páncreas, el número y el área de islotes del páncreas. Y los parámetros de fémur fueron analizados por absorciometría de rayos X de energía dual(DXA) y la tomografía computarizada (CT).Resultados: Las diferencias se consideraron significativas si P < 0,05. Grupos diabéticos mostraron menor (P <0,05): el fémur y la masa páncreas, el área de los islotes pancreáticos y la insulina. Sin embargo, DMY mostró inferior (-10%, P < 0,05) concentraciones de glucosa al grupo DM. Fémur, por DXA, mostró menor densidad mineral ósea, el contenido y el área en el grupo de DM. Mientras que el grupo DMY mostró mayor (27%, P <0,05) radiodensidad de la cabeza femoral en comparación con el grupo de DM. Discusión: Suplemento de harina de ñame brasileña no fijó un defecto, pero alivia las consecuencias de la enfermedad diabética experimental. Se mostró resultados para controlar el aumento de los niveles de glucosa en sangre en ratas diabéticas, lo que sugiere la protección en agentes oxidantes y posponer daño en el hueso. Conclusión: Teniendo en cuenta todos los resultados de este estudio, nuestros resultados sugieren que la harina deñame actúa de producir beneficios en la diabetes experimental (AU)


Assuntos
Animais , Ratos , Dioscorea , Extratos Vegetais/farmacocinética , Hiperglicemia/tratamento farmacológico , Osteogênese Imperfeita/tratamento farmacológico , Camundongos Endogâmicos NOD , Modelos Animais de Doenças , Densidade Óssea
3.
Clinics ; 66(10): 1811-1816, 2011. graf, tab
Artigo em Inglês | LILACS | ID: lil-601918

RESUMO

OBJECTIVES: A low ratio of omega-6/omega-3 polyunsaturated fatty acids is associated with healthy bone properties. However, fatty diets can induce obesity. Our objective was to evaluate intra-abdominal adiposity, insulin, and bone growth in rats fed a high-fat diet containing low ratios of omega-6/omega-3 provided in canola oil. METHODS: After weaning, rats were grouped and fed either a control diet (7S), a high-fat diet containing soybean oil (19S) or a high-fat diet of canola oil (19C) until they were 60 days old. Differences were considered to be significant if p<0.05. RESULTS: After 60 days, the 19S and 19C groups showed more energy intake, body density growth and intraabdominal fat mass. However, the 19S group had a higher area (200 percent) and a lower number (44 percent) of adipocytes, while the 7S and 19C groups did not differ. The serum concentrations of glucose and insulin and the insulin resistance index were significantly increased in the 19C group (15 percent, 56 percent, and 78 percent, respectively) compared to the 7S group. Bone measurements of the 19S and 19C groups showed a higher femur mass (25 percent) and a higher lumbar vertebrae mass (11 percent) and length (5 percent). Computed tomography analysis revealed more radiodensity in the proximal femoral epiphysis and lumbar vertebrae of 19C group compared to the 7S and 19S groups. CONCLUSIONS: Our results suggest that the amount and source of fat used in the diet after weaning increase body growth and fat depots and affect insulin resistance and, consequently, bone health.


Assuntos
Animais , Masculino , Ratos , Densidade Óssea , Osso e Ossos/fisiologia , Dieta Hiperlipídica/efeitos adversos , Crescimento/fisiologia , Insulina/sangue , Gordura Intra-Abdominal/fisiologia , Adiposidade/fisiologia , Glicemia/metabolismo , Osso e Ossos , Ingestão de Energia/fisiologia , Ácidos Graxos Monoinsaturados/efeitos adversos , Resistência à Insulina/fisiologia , Gordura Intra-Abdominal/metabolismo , Ratos Wistar , Óleo de Soja/efeitos adversos , Fatores de Tempo , Tomografia Computadorizada por Raios X
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