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1.
Braz. j. biol ; 83: e250003, 2023. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1339392

RESUMO

Abstract This study estimated the length-weight relationships of 16 fish species occurring close to the shores of sandy beaches along the lower Negro River basin, Brazilian Amazon. The specimens were captured for one day each month, in October to November 2016, early in the morning and early evening, using trawl net (20 m taken for standard length (SL - 0.1 cm precision) and total weight (TW - 0.01 g precision). The parameters a and b of the equation WT = a.LTb were estimated. The a values ranged from 0.0018 to 0.0226 and b values ranged from 2.5271 to 3.3244. This study also provides new data on of maximum lengths for six species, Amazonsprattus scintilla, Brycon pesu, Moenkhausia megalops, Pachyurus paucirastrus, Reganella depressa and Trachydoras microstomus, and new reports of the LWRs parameters of 15 fish species.


Resumo Este estudo estimou as relações comprimento-peso de 16 espécies de peixes que ocorrem às margens de praias arenosas ao longo da bacia do baixo Rio Negro, Amazônia brasileira. As espécies foram capturadas durante um dia de cada mês, de outubro a novembro de 2016, no início da manhã e no início da noite, usando rede de cerco (20 m de comprimento e 3,5 m de altura, 5 malha mm entre nós opostos). As medidas foram feitas para comprimento padrão (SL - precisão de 0,1 cm) e peso total (TW - precisão de 0,01 g). Os parâmetros a e b da equação WT = a.LTb foram estimados. Os valores de a variaram de 0,0018 a 0,0226 e os valores de b variaram de 2,5271 a 3,3244. Este estudo também fornece novos dados sobre comprimentos máximos para seis espécies, Amazonsprattus scintilla, Brycon pesu, Moenkhausia megalops, Pachyurus paucirastrus, Reganella depressa e Trachydoras microstomus, e novos reportes dos parâmetros da LWRs de 15 espécies de peixes.


Assuntos
Animais , Perciformes , Caraciformes , Characidae , Brasil , Rios
2.
Braz. j. biol ; 83: 1-5, 2023. map, tab
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1468965

RESUMO

This study estimated the length–weight relationships of 16 fish species occurring close to the shores of sandy beaches along the lower Negro River basin, Brazilian Amazon. The specimens were captured for one day each month, in October to November 2016, early in the morning and early evening, using trawl net (20 m length and 3.5 m height, 5 mm mesh between opposite knots). Measurements were taken for standard length (SL – 0.1 cm precision) and total weight (TW – 0.01 g precision). The parameters a and b of the equation WT = a.LTb were estimated. The a values ranged from 0.0018 to 0.0226 and b values ranged from 2.5271 to 3.3244. This study also provides new data on of maximum lengths for six species, Amazonsprattus scintilla, Brycon pesu, Moenkhausia megalops, Pachyurus paucirastrus, Reganella depressa and Trachydoras microstomus, and new reports of the LWRs parameters of 15 fish species.


Este estudo estimou as relações comprimento-peso de 16 espécies de peixes que ocorrem às margens de praias arenosas ao longo da bacia do baixo Rio Negro, Amazônia brasileira. As espécies foram capturadas durante um dia de cada mês, de outubro a novembro de 2016, no início da manhã e no início da noite, usando rede de cerco (20 m de comprimento e 3,5 m de altura, 5 malha mm entre nós opostos). As medidas foram feitas para comprimento padrão (SL - precisão de 0,1 cm) e peso total (TW - precisão de 0,01 g). Os parâmetros a e b da equação WT = a.LTb foram estimados. Os valores de a variaram de 0,0018 a 0,0226 e os valores de b variaram de 2,5271 a 3,3244. Este estudo também fornece novos dados sobre comprimentos máximos para seis espécies, Amazonsprattus scintilla, Brycon pesu, Moenkhausia megalops, Pachyurus paucirastrus, Reganella depressa e Trachydoras microstomus, e novos reportes dos parâmetros da LWRs de 15 espécies de peixes.


Assuntos
Animais , Peixes/anatomia & histologia , Peixes/crescimento & desenvolvimento
3.
Braz. j. biol ; 832023.
Artigo em Inglês | LILACS-Express | LILACS, VETINDEX | ID: biblio-1469181

RESUMO

Abstract This study estimated the lengthweight relationships of 16 fish species occurring close to the shores of sandy beaches along the lower Negro River basin, Brazilian Amazon. The specimens were captured for one day each month, in October to November 2016, early in the morning and early evening, using trawl net (20 m taken for standard length (SL 0.1 cm precision) and total weight (TW 0.01 g precision). The parameters a and b of the equation WT = a.LTb were estimated. The a values ranged from 0.0018 to 0.0226 and b values ranged from 2.5271 to 3.3244. This study also provides new data on of maximum lengths for six species, Amazonsprattus scintilla, Brycon pesu, Moenkhausia megalops, Pachyurus paucirastrus, Reganella depressa and Trachydoras microstomus, and new reports of the LWRs parameters of 15 fish species.


Resumo Este estudo estimou as relações comprimento-peso de 16 espécies de peixes que ocorrem às margens de praias arenosas ao longo da bacia do baixo Rio Negro, Amazônia brasileira. As espécies foram capturadas durante um dia de cada mês, de outubro a novembro de 2016, no início da manhã e no início da noite, usando rede de cerco (20 m de comprimento e 3,5 m de altura, 5 malha mm entre nós opostos). As medidas foram feitas para comprimento padrão (SL - precisão de 0,1 cm) e peso total (TW - precisão de 0,01 g). Os parâmetros a e b da equação WT = a.LTb foram estimados. Os valores de a variaram de 0,0018 a 0,0226 e os valores de b variaram de 2,5271 a 3,3244. Este estudo também fornece novos dados sobre comprimentos máximos para seis espécies, Amazonsprattus scintilla, Brycon pesu, Moenkhausia megalops, Pachyurus paucirastrus, Reganella depressa e Trachydoras microstomus, e novos reportes dos parâmetros da LWRs de 15 espécies de peixes.

4.
Braz J Biol ; 83: e250003, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34669803

RESUMO

This study estimated the length-weight relationships of 16 fish species occurring close to the shores of sandy beaches along the lower Negro River basin, Brazilian Amazon. The specimens were captured for one day each month, in October to November 2016, early in the morning and early evening, using trawl net (20 m taken for standard length (SL - 0.1 cm precision) and total weight (TW - 0.01 g precision). The parameters a and b of the equation WT = a.LTb were estimated. The a values ranged from 0.0018 to 0.0226 and b values ranged from 2.5271 to 3.3244. This study also provides new data on of maximum lengths for six species, Amazonsprattus scintilla, Brycon pesu, Moenkhausia megalops, Pachyurus paucirastrus, Reganella depressa and Trachydoras microstomus, and new reports of the LWRs parameters of 15 fish species.


Assuntos
Characidae , Caraciformes , Perciformes , Animais , Brasil , Rios
5.
J Laryngol Otol ; 131(7): 627-630, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28462728

RESUMO

BACKGROUND: Peritonsillar abscess is the most common deep infection of the head and neck in young adults. It is considered a purulent complication of acute tonsillitis, but other mechanisms have been proposed. There is no consensus as to whether seasonality affects peritonsillar abscess incidence. METHODS: This observational, descriptive, retrospective study explored the epidemiology of peritonsillar abscess and its relationship with seasonality. The cases were selected from the emergency otolaryngology service of a tertiary hospital. RESULTS: The sample comprised 528 patients (42.61 per cent males, mean age = 26.63 years). A moderate positive correlation was found between peritonsillar abscess incidence and monthly average temperature. No associations were found with insolation, precipitation or humidity. CONCLUSION: In this sample, peritonsillar abscess was more likely to occur in warmer months. The findings corroborate the theory that peritonsillar abscess is not a direct complication of acute tonsillitis and may improve understanding of peritonsillar abscess aetiology.


Assuntos
Clima , Abscesso Peritonsilar/epidemiologia , Abscesso Peritonsilar/etiologia , Adolescente , Adulto , Fatores Etários , Idoso , Brasil , Criança , Estudos Transversais , Feminino , Humanos , Umidade , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Estatística como Assunto , Temperatura , Clima Tropical , Adulto Jovem
6.
J Colloid Interface Sci ; 426: 308-13, 2014 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-24863798

RESUMO

The present work reports the production of films on AA2024-T3 composed of vinyltrimethoxysilane (VTMS)/tetraethylorthosilicate (TEOS) with incorporation of montmorillonite (sodium montmorillonite and montmorillonite modified with quaternary ammonium salt, abbreviated Na and 30B, respectively), generated by the sol-gel process. According to FT-IR analyses the incorporation of montmorillonite does not affect silica network. Electrochemical characterization was performed by electrochemical impedance spectroscopy measurement in 0.05 mol L(-1) NaCl solution. Results indicate that montmorillonite incorporation improves the corrosion protection compared to the non-modified system. Scanning electron microscopy micrographs reveal that high concentrations of montmorillonite provide agglomerations on the metallic surface, which is in detriment of the anticorrosive performance. The VTMS/TEOS/30B films with the lowest concentration (22 mg L(-1)) of embedded clay provide the highest corrosion protection.

7.
Colloids Surf B Biointerfaces ; 116: 510-7, 2014 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-24572495

RESUMO

The effects of sol-gel processes, i.e., acid-catalyzed gelation, base-catalyzed gelation and base-catalyzed precipitation routes, on the encapsulation of gentamicin were investigated. The resulting xerogels were characterized using a series of complementary instrumental techniques, i.e., the adsorption/desorption of nitrogen, small-angle X-ray scattering, Fourier transform infrared spectroscopy, diffuse reflectance spectroscopy, X-ray photoelectron spectroscopy, atomic force microscopy and scanning electron microscopy. The encapsulated gentamicin samples were tested against a series of Gram-positive and Gram-negative bacterial strains. The best antimicrobial activity was observed with the encapsulated gentamicin that was prepared via the precipitation route, even in comparison with the neat antibiotic, especially in the case of the Gram-positive strain Staphylococcus aureus. The gentamicin concentration on the outermost surface and the zeta potential were identified as factors that affected the highest efficiency, as observed in the case of encapsulation via the base-catalyzed process.


Assuntos
Antibacterianos/farmacologia , Gentamicinas/farmacologia , Dióxido de Silício/química , Staphylococcus aureus/efeitos dos fármacos , Antibacterianos/síntese química , Antibacterianos/química , Relação Dose-Resposta a Droga , Géis/síntese química , Géis/química , Gentamicinas/síntese química , Gentamicinas/química , Testes de Sensibilidade Microbiana , Estrutura Molecular , Tamanho da Partícula , Relação Estrutura-Atividade , Propriedades de Superfície
8.
J Hazard Mater ; 163(2-3): 531-7, 2009 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-18692306

RESUMO

Metal (Fe, Mn, Zn, Ni, Cd, and Pb) concentrations in the region of Criciuma (Brazil), a region impacted by coal mining, were determined in water and sediments using total reflection X-ray fluorescence (TXRF) spectroscopy. Samples were collected from the Mãe Luzia River (south Brazil) at five different stations, from the source down to the river mouth (Ararangua estuary). Water and sediment toxicity were also evaluated using bioassays with Daphnia magna as the bioindicator. The metal present in the highest concentrations both in water (1.3-11 mg L(-1)) and in sediments (34-142 mg L(-1)) was iron. Results suggest an influence of coal mining on the aquatic receptors, showing a clear relationship between metal content (mostly Fe) and ecotoxicity.


Assuntos
Minas de Carvão , Água Doce/análise , Metais/análise , Poluentes Químicos da Água/toxicidade , Animais , Brasil , Daphnia , Monitoramento Ambiental , Sedimentos Geológicos/análise , Resíduos Industriais/análise , Espectrometria de Fluorescência , Poluentes Químicos da Água/análise , Raios X
9.
Spectrochim Acta A Mol Biomol Spectrosc ; 71(1): 45-52, 2008 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-18221911

RESUMO

Thermal decomposition studies of the free polyhedral oligomeric silsesquioxane, POSSh, and when this compound has been impregnated with Cp2ZrCl2 (Cp = eta5-C5H5) or immobilized on SiO2 were conducted using infrared emission spectroscopy (IES) over a 100-1000 degrees C temperature range and by thermogravimetric analysis (TGA). The organic groups in POSS(h) apparently decompose thermally into Si-CH3, Si-H and other fragments. Upon impregnation with Cp2ZrCl2, however, a different thermal decomposition pathway was followed and new infrared emission bands appeared in the 1000-900 cm(-1) region suggesting the formation of Si-O-Zr moieties. When immobilized on SiO2 and subjected to thermal decomposition, the POSSh compound lost its organic groups and the inorganic structure remaining was incorporated into the SiO2 framework.


Assuntos
Compostos Organometálicos/química , Dióxido de Silício/química , Espectrofotometria/métodos , Catálise , Química/métodos , Temperatura Alta , Modelos Químicos , Compostos de Organossilício/química , Compostos de Amônio Quaternário/química , Espectrofotometria Infravermelho/métodos , Temperatura , Termogravimetria/métodos
10.
Artigo em Inglês | MEDLINE | ID: mdl-17320474

RESUMO

FT-IR photoacoustic and Raman spectroscopy have been used to study the interactions between the metallocene catalyst, Cp(2)ZrCl(2) (Cp=eta(5)-C(5)H(5)), and two polyhedral oligomeric silsesquioxanes (POSS) supports. The first silsesquioxane support, POSS(h), contains (beta-hydroxyl)-tertiary amine groups, while in the second one, POSS(u), these -OH groups have been converted into N-(p-toluyl) urethane groups. The vibrational spectra of the Cp(2)ZrCl(2):POSS(h) and Cp(2)ZrCl(2):POSS(u) samples show that the Cp(2)ZrCl(2) catalyst reacts with the C-OH groups of POSS(h) and also interacts with N-H and >CO groups of POSS(u). Furthermore, Cp(2)ZrCl(2) can react with the Si-OH groups of the POSS supports and also interact with the O atoms that are bonded to the benzene rings and the N atoms of the tertiary amines in both silsesquioxanes. As a result of the interactions between Cp(2)ZrCl(2) and the POSS supports, acidic species are generated. The Cp(2)ZrCl(2):POSS(h) mass ratio seems to be an important parameter in the formation of Zr-O bonds and the acidic species.


Assuntos
Compostos Organometálicos/química , Compostos de Organossilício/química , Análise Espectral Raman , Vibração , Zircônio/química , Catálise , Uretana/química
11.
Eur J Vasc Endovasc Surg ; 28(4): 387-90, 2004 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-15350560

RESUMO

OBJECTIVES: To determine the prevalence and distribution of primary venous reflux in the lower limbs in patients without truncal saphenous reflux. DESIGN: Prospective cohort study. PATIENTS AND METHODS: One thousand and seven hundred and twelve patients with suspected venous disease were examined by duplex ultrasonography. Seven hundred and thirty-five patients had primary varicose veins with competent saphenous trunks. Limbs with truncal saphenous reflux, deep vein reflux or obstruction, previous injection sclerotherapy or vein surgery, arterial disease and inflammation of non-venous origin were excluded from further consideration. The CEAP classification system was used for clinical staging. Systematic duplex ultrasound examination was undertaken to assess the distribution of incompetent saphenous tributaries. RESULTS: The prevalence of primary reflux with competent saphenous trunks was 43%. Reflux of GSV calf tributaries was the most common. The majority of the limbs (96%) belonged to chronic venous disease classes C1 and C2 of the CEAP classification. CONCLUSIONS: Superficial venous reflux causing varicose veins in the presence competent saphenous trunks is very prevalent in this series in contrast to other studies, presumably reflecting differing patient populations. Our data clearly show that varicose veins may occur in any vein and do not depend on truncal saphenous incompetence. Careful duplex ultrasound evaluation allows the pattern of venous reflux to be established in this group of patient ensuring appropriate management of varices.


Assuntos
Extremidade Inferior/irrigação sanguínea , Metenamina/análogos & derivados , Varizes/epidemiologia , Adolescente , Adulto , Idoso , Brasil/epidemiologia , Doença Crônica , Feminino , Humanos , Extremidade Inferior/diagnóstico por imagem , Masculino , Ácidos Mandélicos , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Fluxo Sanguíneo Regional/fisiologia , Veia Safena/anatomia & histologia , Veia Safena/diagnóstico por imagem , Veia Safena/patologia , Ultrassonografia Doppler Dupla , Varizes/diagnóstico por imagem , Varizes/fisiopatologia , Grau de Desobstrução Vascular/fisiologia
12.
Rev Esp Cardiol ; 54(2): 239-42, 2001 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-11181315

RESUMO

The mortality observed in pacemaker endocarditis may be high when all the components of the device are not withdrawn. Few studies have reported the posterior morbidity once the acute disease is resolved. Herein we present a patient who developed superior vena cava thrombosis, obstruction of thoracic duct and chylothorax after the initial episode of endocarditis. The evolution of the patient illustrates the late complications of isolated antibiotic treatment of pacemaker endocarditis, the poor results obtained with temporal oral anticoagulation in the management of superior vena cava thrombosis in the presence of retained intravascular foreign material, the excellent, prolonged initial response of chylothorax to conservative measures with anticoagulation and diet, relapse of chylothorax related to the increase in arterial pulmonary pressure, the absence of response at this time to the dietary measures and the successful treatment with video-assisted thoracic surgery to treat chylothorax without the morbidity of the large surgical procedures.


Assuntos
Quilotórax/etiologia , Endocardite Bacteriana/complicações , Marca-Passo Artificial/efeitos adversos , Infecções Relacionadas à Prótese/complicações , Infecções Estafilocócicas/complicações , Idoso , Humanos , Masculino , Fatores de Tempo
13.
Mutat Res ; 444(2): 355-65, 1999 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-10521675

RESUMO

The wing Somatic Mutation And Recombination Test (SMART) in Drosophila melanogaster was used to study the modulating action of vanillin (VA) in combination with the alkylating agents mitomycin C (MMC), methylmethanesulphonate (MMS) and the bifunctional nitrogen mustard (HN2). Two types of treatments with VA and each of the three genotoxins were performed: chronic co-treatments of three-day-old larvae of the standard cross as well as post-treatments after acute exposure with the genotoxins. This allowed the study of the action of VA not only in the steps that precede the induction of DNA lesions but also in the repair processes. The overall findings from the co-treatment series suggest that ingestion of VA with MMS or MMC can lead to significant protection against genotoxicity; but this is not the case with HN2. Antioxidant activity, suppression of metabolic activation or interaction with the active groups of these two alkylating agents could be mechanisms by means of which VA exerts its desmutagenic action. In contrast, when evaluated in the post-treatment procedure, VA causes two antagonistic effects on the genotoxicity of MMC: (i) synergism on recombination (172.8%) and (ii) protection against mutation (79.0%). Consequently, both activities together lead to a considerable increase in mitotic recombination. In spite of being separate events, recombination and gene mutation are correlated during mitosis since the fate of a DNA lesion depends on the repair pathway followed. Our results may suggest that VA is a modifying factor that blocks the mutagenic pathway and consequently directs the MMC-induced lesions into a recombinational repair. Furthermore, VA did not modify the genotoxicity when administered after treatments with HN2 or MMS. Therefore, the major finding of the present study, namely the co-recombinagenic activity of VA on MMC-induced lesions, seems to be related to the type of induced lesion and consequently to the repair processes involved in its correction.


Assuntos
Antimutagênicos/farmacologia , Benzaldeídos/farmacologia , Mitomicina/toxicidade , Recombinação Genética , Animais , Drosophila melanogaster , Sinergismo Farmacológico , Feminino
14.
Thromb Res ; 93(1): 1-8, 1999 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-10065893

RESUMO

A common G to A transition at nucleotide 20210 of the prothrombin gene is associated with an increased risk for deep-vein thrombosis (DVT) and high plasma levels of prothrombin. We calculated the prevalences of prothrombin G20210A, factor V G1691A (also associated with high risk for DVT) and homozygous methylenetetrahydrofolate reductase (MTHFR) C677T (associated with increased susceptibility to develop hyperhomocysteinemia) in 118 patients with a first episode of DVT and in 416 healthy controls. 15.9% of the patients and 2.3% of the controls had prothrombin G20210A (odds ratio [OR]: 8.7, 95% C.I.: 3.8-21.4); 21.1% of the patients and 3.2% of the controls had factor V G1691A (OR 7.8, 3.9-17.1); 20.5% of the patients and 21% of the controls had homozygous MTHFR C677T (OR: 1.0, 0.7-1.2). Exclusion of patients with other hereditary risk factors for DVT did not substantially modify the results. Mutant factor V and prothrombin coexisted in three patients but in no control. The concomitant presence of the MTHFR mutation did not increase the thrombotic risk associated with prothrombin G20210A. 63.2% of individuals with prothrombin G20210A had plasma levels of prothrombin in the upper quartile of distribution. After adjustment for age and sex, subjects with prothrombin levels in the upper quartile carried a slightly higher risk for thrombosis than those with lower prothrombin concentrations (OR: 1.9, 1.1-3.2). In conclusion, we found that prothrombin G20210A is relatively common in Italy and is associated with high prothrombin levels and an 8.7-fold increase in the risk for DVT. Such risk is independent of the coexistence of other known inherited risk factors for thrombosis and increases in patients with associated mutant factor V. Whether it is due to the associated increase in plasma prothrombin levels remains to be established.


Assuntos
Fator V/genética , Oxirredutases atuantes sobre Doadores de Grupo CH-NH/genética , Protrombina/genética , Trombose Venosa/genética , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Criança , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Metilenotetra-Hidrofolato Redutase (NADPH2) , Pessoa de Meia-Idade , Mutação , Prevalência , Protrombina/metabolismo , Fatores de Risco , Trombose Venosa/sangue , Trombose Venosa/epidemiologia
15.
Mutat Res ; 308(2): 143-8, 1994 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-7518041

RESUMO

To investigate the effects of tannic acid (TA) on ring-X chromosome loss, Drosophila melanogaster females exposed to different TA concentrations were crossed with untreated, methyl methanesulfonate (MMS)- or mitomycin C (MMC)-treated males which carried a ring-X chromosome. Progeny were analyzed for loss of the ring-X. The results of this in vivo study showed that TA had no suppressing effect on chromosome loss occurring spontaneously or after induction by MMS in mature spermatozoa. In contrast, TA caused a significant increase in the frequency of MMC-induced ring-X loss. The increase caused by this co-mutagenic effect reached values of 34, 33 and 40% at TA concentrations of 10, 25 and 50 mM, respectively. These increments may reflect the action of TA on a uvrABC-type enzyme which, by increasing the double-strand breaks (DSBs), somehow interferes with the post-replicational repair responsible for the final DSB correction.


Assuntos
Deleção Cromossômica , Drosophila melanogaster/efeitos dos fármacos , Taninos Hidrolisáveis/toxicidade , Mutagênicos/toxicidade , Cromossomo X/efeitos dos fármacos , Animais , Antimutagênicos/farmacologia , Distribuição de Qui-Quadrado , Reparo do DNA/efeitos dos fármacos , Drosophila melanogaster/genética , Sinergismo Farmacológico , Feminino , Masculino , Metanossulfonato de Metila/toxicidade , Mitomicina/toxicidade , Testes de Mutagenicidade , Cromossomos em Anel , Espermatozoides/efeitos dos fármacos
16.
Mutat Res ; 279(4): 281-7, 1992 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-1377784

RESUMO

In order to investigate the anticlastogenic effect of vanillin on ring-X loss, D. melanogaster females exposed to different vanillin concentrations were crossed with non-treated, MMC- or MMS-treated males. The results obtained with this in vivo investigation showed a significant inhibition of vanillin in the frequencies of spontaneous ring-X loss--59, 56, 38 and 36%--at the different concentrations used. In addition, vanillin treatment caused a significant suppression of MMC-induced ring-X loss. This decrease was observed only in the first 3 days after the interruption of vanillin treatment and at the concentrations of 0.5 and 1% of this flavoring agent. In contrast, vanillin did not show any effect on chromosome loss provoked by MMS. Therefore, the ring-X loss-decreasing effect of vanillin seemed to depend on the quality of DNA lesions and consequently on a specific enzymatic repair process present in the oocytes of D. melanogaster.


Assuntos
Antimutagênicos/farmacologia , Benzaldeídos/farmacologia , Deleção Cromossômica , Reparo do DNA , Animais , Distribuição de Qui-Quadrado , Drosophila melanogaster/genética , Feminino , Masculino , Mitomicina , Testes de Mutagenicidade , Oócitos/efeitos dos fármacos , Cromossomos em Anel , Espermatozoides/efeitos dos fármacos , Cromossomo X/efeitos dos fármacos
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