Cystic fibrosis: when neonatal screening is unsatisfactory for early diagnosis / Fibrose cística: quando a triagem neonatal é insatisfatória para o diagnóstico precoce

Abstract Introduction: cystic fibrosis newborn screening must enable its earlier diagnosis, which may enhance outcomes. This study was a series case of delayed-diagnosis children submitted to cystic fibrosis newborn screening. Description: fourteen children were included; eight (57.1%) were due to false-negative screening, while six (42.9%) were due to processing errors. Two samples collected after 30 days of life were incorrectly classified as negative, and four infants with a positive test could not be located due to screening processing errors. Cystic fibrosis diagnosis was confirmed at a median (IQR) age of 5.3 (4.2-7.4) months. Poor nutritional status was the most prevalent clinical sign at diagnosis, being present in 78.6% of infants. The mean (SD) weight-for-length and length-for-age Z-scores were -3.46 (0.84) and -3.99 (1.16), respectively. Half of the children had Pseudo-Bartter syndrome, and 42.9% had breathing difficulties. Twelve children (85.7%) required hospitalization, with a median (IQR) length of stay of 17.0 (11.5-26.5) days. Discussion: newborn screening had some faults, from incorrect collections to inefficient active search. Early identification of these children in which screening was unsatisfactory is essential, emphasizing the importance and efforts to not miss them. In the case of a failed test, healthcare professionals must be prepared to recognize the main symptoms and signs of the disease.

Resumo Introdução: a triagem neonatal para fibrose cística deve contribuir para diagnóstico precoce e melhor prognóstico da doença. O estudo é uma série de casos com lactentes submetidos à triagem, porém com diagnóstico tardio da doença. Descrição: quatorze crianças foram incluídas; oito (57,1%) com triagem falso-negativo e seis (42,9%) com erros processuais na triagem neonatal. Duas amostras foram coletadas tardiamente, sendo incorretamente classificadas como negativas e quatro lactentes com triagem positiva não foram localizados, por erros na busca ativa. Confirmou-se o diagnóstico da fibrose cística com idade mediana (IIQ) de 5,3 (4,2-7,4) meses. O Comprometimento nutricional precoce foi o sinal clínico mais prevalente ao diagnóstico, presente em 78,6% das crianças. Os Z escores médios (SD) do peso para altura e altura para idade foram -3,46 (0,84) e -3,99 (1,16), respectivamente. Metade das crianças teve síndrome de Pseudo-Bartter e 42,9% dificuldade respiratória. Doze crianças (85,7%) precisaram hospitalização com tempo mediano de permanência de 17 dias. Discussão: a triagem neonatal para fibrose cística apresentou falhas, desde testes falso-negativos, coletas incorretas, até problemas com a busca ativa. Entretanto, o diagnóstico ágil é essencial e os profissionais de saúde devem reconhecer os sintomas e sinais precoces da doença, mesmo quando a triagem neonatal não for satisfatória.

[Duration of remote work and a positive diagnosis of COVID-19: an analysis of PNAD COVID19 data]. / Duração do trabalho remoto e diagnóstico positivo de COVID-19: análises dos dados da PNAD COVID19.

The scope of this work was to assess the association between the duration of remote work and a positive diagnosis of COVID-19 among individuals employed in Brazil. Data from the PNAD COVID19 (2020) survey were consulted. The variables in the work situation described included: absence from work due to physical distancing, work segment (work sector and formality: formal or informal private, military, statutory civil servant, CLT public sector, informal public sector, employer, self-employed/unpaid worker) and duration of remote work (no remote work for 1-2 months, 3-4 months, 5-7 months, respectively). The association between duration of remote work (exposure) and positive diagnosis for COVID-19 (outcome) was estimated by Cox regression, with adjustment for sociodemographic variables and work segment. The positive diagnosis of COVID-19 increased from 2.1% to 4.8% between July and November, and the frequency of remote work decreased from 11.6% to 9.5% between May and November. The risk of a positive diagnosis of COVID-19 was lower for people working remotely for 3-4 months, (HR=0.79; CI95%=0.67;0.92) and 5-7 months (HR=0.57; CI95%=0.48;0.67) compared to those who did not work remotely. There was a slight decrease in the percentage of remote work employees, and a longer duration reduced the risk of a positive diagnosis for COVID-19.

Nosso objetivo foi analisar a associação entre a duração do trabalho remoto e o diagnóstico positivo da COVID-19 entre pessoas ocupadas no Brasil. Foram utilizados dados da PNAD COVID19 (2020). As variáveis sobre a situação do trabalho descritas foram: afastamento do trabalho em função do distanciamento físico, segmento de trabalho (setor de trabalho e formalidade: privado formal/informal, militar, servidor público estatutário, setor público CLT/informal, empregador, conta-própria/trabalhador não remunerado) e duração do trabalho remoto (sem trabalho remoto, 1-2 meses, 3-4 meses, 5-7 meses). Associação entre duração do trabalho remoto (exposição) e diagnóstico positivo para COVID-19 (desfecho) foi estimada por regressão de Cox, com ajuste para variáveis sociodemográficas e segmento de trabalho. O diagnóstico positivo da COVID-19 aumentou de 2,1% para 4,8% entre julho e novembro, e a frequência de trabalho remoto reduziu de 11,6% para 9,5% entre maio e novembro. O risco de diagnóstico positivo da COVID-19 foi menor para pessoas que trabalharam remotamente por 3-4 meses (RR=0,79; IC95%=0,67;0,92) e 5 meses (RR=0,57; IC95%=0,48;0,67) comparadas àquelas que não trabalharam remotamente. Houve discreta redução do percentual de trabalhadores em trabalho remoto e sua maior extensão reduziu o risco de diagnóstico positivo para COVID-19.

Sympathetic neural overdrive and diminished exercise capacity in reduced ejection fraction heart failure related to anthracycline-based chemotherapy.

Cardiotoxicity is the most worrying cardiovascular alteration in patients treated with chemotherapy. To improve the understanding regarding the cardiotoxicity, we studied whether 1) patients with cardiac dysfunction related to anthracycline-based chemotherapy have augmented sympathetic nerve activity and decreased exercise capacity and 2) these responses are similar to those observed in patients with heart failure caused by other etiologies. Sixteen patients with heart failure with reduced ejection fraction related to anthracycline-based chemotherapy with or without chest radiation (HFrEFCA), 10 patients with heart failure with reduced ejection not related to cancer therapy (HFrEF), and 16 age- and body mass index (BMI)-matched healthy control subjects were studied. Left ventricular ejection fraction (LVEF, echocardiography), peak oxygen consumption (peak V̇o2, cardiopulmonary exercise test), muscle sympathetic nerve activity (MSNA, microneurography), and forearm blood flow (FBF, venous occlusion plethysmography) were measured. We found that peak oxygen consumption peak V̇o2 and LVEF were significantly reduced in patients with HFrEFCA compared with that of control subjects (P < 0.0001) but similar to those found in patients with HFrEFCA. The sympathetic nerve activity burst frequency and incidence were significantly higher in patients with HFrEFCA than that in control subjects (P < 0.0001). No differences were found between patients with HFrEF and HFrEFCA. Peak V̇o2 was inversely associated with MSNA burst frequency (r = -0.53, P = 0.002) and burst incidence (r = -0.38, P = 0.01) and directly associated with LVEF (r = 0.71, P < 0.0001). Taken together, we conclude that patients who develop heart failure due to anthracycline-based chemotherapy have sympathetic neural overdrive and reduced exercise capacity. In addition, these physiological changes are similar to those observed in patients with HFrEF.NEW & NOTEWORTHY Patients with heart failure with reduced ejection fraction related to anthracycline-based chemotherapy have increased sympathetic nerve activity and decreased exercise capacity. These alterations in autonomic control and physical capacity are similar to those observed in patients with heart failure due to other etiologies. These findings highlight the importance of special care of oncological patients treated with chemotherapy.

Duração do trabalho remoto e diagnóstico positivo de COVID-19: análises dos dados da PNAD COVID19 / Duration of remote work and a positive diagnosis of COVID-19: an analysis of PNAD COVID19 data

Resumo Nosso objetivo foi analisar a associação entre a duração do trabalho remoto e o diagnóstico positivo da COVID-19 entre pessoas ocupadas no Brasil. Foram utilizados dados da PNAD COVID19 (2020). As variáveis sobre a situação do trabalho descritas foram: afastamento do trabalho em função do distanciamento físico, segmento de trabalho (setor de trabalho e formalidade: privado formal/informal, militar, servidor público estatutário, setor público CLT/informal, empregador, conta-própria/trabalhador não remunerado) e duração do trabalho remoto (sem trabalho remoto, 1-2 meses, 3-4 meses, 5-7 meses). Associação entre duração do trabalho remoto (exposição) e diagnóstico positivo para COVID-19 (desfecho) foi estimada por regressão de Cox, com ajuste para variáveis sociodemográficas e segmento de trabalho. O diagnóstico positivo da COVID-19 aumentou de 2,1% para 4,8% entre julho e novembro, e a frequência de trabalho remoto reduziu de 11,6% para 9,5% entre maio e novembro. O risco de diagnóstico positivo da COVID-19 foi menor para pessoas que trabalharam remotamente por 3-4 meses (RR=0,79; IC95%=0,67;0,92) e 5 meses (RR=0,57; IC95%=0,48;0,67) comparadas àquelas que não trabalharam remotamente. Houve discreta redução do percentual de trabalhadores em trabalho remoto e sua maior extensão reduziu o risco de diagnóstico positivo para COVID-19.

Abstract The scope of this work was to assess the association between the duration of remote work and a positive diagnosis of COVID-19 among individuals employed in Brazil. Data from the PNAD COVID19 (2020) survey were consulted. The variables in the work situation described included: absence from work due to physical distancing, work segment (work sector and formality: formal or informal private, military, statutory civil servant, CLT public sector, informal public sector, employer, self-employed/unpaid worker) and duration of remote work (no remote work for 1-2 months, 3-4 months, 5-7 months, respectively). The association between duration of remote work (exposure) and positive diagnosis for COVID-19 (outcome) was estimated by Cox regression, with adjustment for sociodemographic variables and work segment. The positive diagnosis of COVID-19 increased from 2.1% to 4.8% between July and November, and the frequency of remote work decreased from 11.6% to 9.5% between May and November. The risk of a positive diagnosis of COVID-19 was lower for people working remotely for 3-4 months, (HR=0.79; CI95%=0.67;0.92) and 5-7 months (HR=0.57; CI95%=0.48;0.67) compared to those who did not work remotely. There was a slight decrease in the percentage of remote work employees, and a longer duration reduced the risk of a positive diagnosis for COVID-19.

Innovative Antibacterial, Photocatalytic, Titanium Dioxide Microstructured Surfaces Based on Bacterial Adhesion Enhancement.

Bacterial colonization and biofilm formation are found on nearly all wet surfaces, representing a serious problem for both human healthcare and industrial applications, where traditional treatments may not be effective. Herein, we describe a synergistic approach for improving the performance of antibacterial surfaces based on microstructured surfaces that embed titanium dioxide nanoparticles (TiO2 NPs). The surfaces were designed to enhance bacteria entrapment, facilitating their subsequent eradication by a combination of UVC disinfection and TiO2 NPs photocatalysis. The efficacy of the engineered TiO2-modified microtopographic surfaces was evaluated using three different designs, and it was found that S2-lozenge and S3-square patterns had a higher concentration of trapped bacteria, with increases of 70 and 76%, respectively, compared to flat surfaces. Importantly, these surfaces showed a significant reduction (99%) of viable bacteria after just 30 min of irradiation with UVC 254 nm light at low intensity, being sixfold more effective than flat surfaces. Overall, our results showed that the synergistic effect of combining microstructured capturing surfaces with the chemical functionality of TiO2 NPs paves the way for developing innovative and efficient antibacterial surfaces with numerous potential applications in the healthcare and biotechnology market.

A novel label-free electrochemical immunosensor for detection of surfactant protein B in amniotic fluid.

The deficiency of Surfactant Protein B (SPB) in Amniotic Fluid (AF) has been associated with severe respiratory pathologies in newborns such as respiratory distress syndrome (RDS). Early-stage diagnosis of these respiratory complications by monitoring the SPB in AF could be a significant clinical tool and the first step toward adopting efficient therapy. In this work, we report the development of a novel sensitive electrochemical immunosensor for the detection of SPB in human AF samples. The surface biofunctionalization steps were characterized by using Electrochemical Impedance Spectroscopy (EIS), cyclic voltammetry, and quartz crystal microbalance techniques. The performance of the immunosensor was investigated by EIS, showing a linear dynamic range between 2 ng/mL and 2000 ng/mL and a limit of detection of 0.1 ng/mL. The immunosensor was also selective and specific to other surfactant proteins presented in AF. To the best of our knowledge, this is the first developed electrochemical biosensor for SPB detection. More significant, the immunosensor developed is simpler than the traditional enzyme-linked immunosorbent assay, and present a higher sensitivity for SPB, indicating that it could be a promising alternative approach for SPB detection in the clinical diagnosis.

Complicações transfusionais em pacientes idosos hospitalizados: revisão integrativa da literatura / Complicaciones transfusionales en ancianos hospitalizados: revisión integrativa de la literatura / Transfusion complications in hospitalized elderly patients: integrative literature review

Objetivo: identificar as principais complicações ocasionadas pela transfusão sanguínea à saúde do idoso hospitalizado através da análise das evidências científicas. Método: revisão integrativa realizada com estudos em inglês provenientes de bases de dados nacionais e internacionais publicados no período de 2017 a 2021. Os principais descritores foram "Blood Transfusion", "Transfusion Reaction", "Aged" e "Hospitalization", combinados por meio dos operadores booleanos "AND" e "OR". Resultados: foram incluídos 23 estudos que retratavam as principais complicações da transfusão sanguínea para a pessoa idosa hospitalizada. As doze diferentes complicações foram alocadas em duas categorias: relacionadas a cirurgias ou complicações não-cirúrgicas. Maior tempo de permanência hospitalar, mortalidade, reações transfusionais, lesão renal aguda pós-operatória e delirium pós-operatório fizeram parte dos principais achados. Conclusão: os mecanismos pelos quais as complicações se desenvolvem ainda não estão totalmente esclarecidos, evidenciando a importância do estímulo à realização de novas pesquisas que envolvam esta temática.

Objective: to identify the main complications caused by blood transfusion to the health of the hospitalized elderly through the analysis of scientific evidence. Method: integrative review conducted with studies in English from national and international databases published in the period from 2017 to 2021. The main descriptors were "BloodTransfusion", "Transfusion Reaction", "Aged" and "Hospitalization", combined by means of the Boolean operators "AND" and "OR". Results: 23 studies were included that depicted the main complications of blood transfusion for the hospitalized elderly person. The twelve different complications were allocated into two categories: surgery-related or non-surgical complications. Longer hospital stay, mortality, transfusion reactions, postoperative acute kidney injury and postoperative delirium were among the mainachievements. Conclusion: the mechanisms by which complications develop are not yet fully understood, highlighting the importance of encouraging further research on this topic.

Objetivo: identificar las principales complicaciones ocasionadas por la transfusión sanguínea a la salud del idoso hospitalizado a través del análisis de las evidencias científicas. Método: revisión integradora realizada con estudios en inglés de bases de datos nacionales e internacionales publicados en el período 2017 a 2021. Los descriptores principales fueron "BloodTransfusion", "Transfusion Reaction", "Aged" y "Hospitalization", combinados mediante los operadores booleanos "AND" y "OR". Resultados:se incluyeron 23 estudios que retrataban las principales complicaciones de la transfusión sanguínea en el anciano hospitalizado. Las doce complicaciones diferentes se asignaron a dos categorías: complicaciones relacionadas con la cirugía o complicaciones no relacionadas con la cirugía. La prolongación de la estancia hospitalaria, la mortalidad, las reacciones transfusionales, la lesión renal aguda postoperatoria y el delirio postoperatorio formaron parte de las principales. Conclusión: los mecanismos por los que se desarrollan las complicaciones aún no se comprenden del todo, lo que pone de relieve la importancia de fomentar la investigación sobre este tema.

The trend of services provided by human milk banks between 2010 and 2019 in Brazil

Abstract Objective: To describe the trend of participation in group and individual support by human milk banks (HMBs) provided between 2010 and 2019 in Brazil. Methods: Ecological study with data from participation in group and individual support provided by the HMBs between 2010 and 2019, available in the production report of the Brazilian Network of Human Milk Banks. The number of participation in group and individual support was expressed for Brazil and for Brazilian macroregions in absolute numbers. Trend analysis was performed from the analysis of index numbers, considering the year 2010 as a reference. It was calculated the ratio of the number of participation in group and individual support by HMBs for each macroregion and year. Results: There was an increase of 42% in participation in group support (300,595 in 2010 vs 425,570 in 2019) and an increase of 69% in individual support (1,157,038 in 2010 vs 1,962,162 in 2019). The North and Northeast macroregions had the highest growth rates in the provision of these services (122 and 131%, respectively), above the national growth rate in the study period. In contrast, the Midwest region showed a downward trend throughout this period, for both types of support. However, in the Midwest, there was a higher ratio of participation in groups by HMBs between 2010 and 2016 and for individual support by HMBs between 2010 and 2012. Conclusion: Individual and group support provided by the HMB as a strategy to support breastfeeding increased considerably in Brazil during the study period, especially in the North and Northeast regions.

Atuação do Fonoaudiólogo na Gestão em Saúde Pública em um Estado do sul do Brasil

Objetivo: Documentar as atividades do fonoaudiólogo na gestão em saúde, apresentando o perfil dos profissionais e suas atribuições nos setores em que atuam. Métodos: Trata-se de um estudo transversal de investigação quantitativa e qualitativa, realizado através de um questionário virtual e autoaplicável. Resultados: Participaram do estudo 20 profissionais, todas do sexo feminino, a maioria na faixa etária entre 31 e 40 anos, com vínculo empregatício de concursada. A inserção das profissionais iniciou em 1998, concentrando-se nos anos de 2014 e 2015. A maior parte iniciou na Macrorregião Metropolitana, sem experiência prévia no âmbito da gestão em saúde pública. Quanto às atribuições das fonoaudiólogas no cargo de gestão em saúde, citaram a regulação de exames e consultas em especialidades, o trabalho interdisciplinar e intersetorial, a realização de educação em saúde para profissionais e usuários, a coordenação de políticas públicas em saúde, o planejamento e monitoramento das ações de saúde. A política pública citada com maior frequência foi a Saúde da Pessoa com Deficiência, especialmente, na área de Reabilitação Auditiva. Conclusões: Pode-se considerar que a presença deste profissional na equipe gestora é essencial para fomentar e trazer visibilidade para a Fonoaudiologia no âmbito da Saúde Pública.

A novel portable label-free electrochemical immunosensor for ultrasensitive detection of Aeromonas salmonicida in aquaculture seawater.

Infectious diseases caused by Aeromonas salmonicida (A. salmonicida) have a huge impact and produce significant losses in aquaculture and fish farming. Fish pathogen early detection is a critical step for the rapid identification and prevention of these problems. This work presents a novel portable label-free ultrasensitive electrochemical immunosensor for A. salmonicida detection in seawater. It consists of a fluidic integrated electrochemical-cell-chip (ECC) with independent chambers enclosing three electrochemical cells (ECs). Anti-A. salmonicida (AbSalm) antibodies were covalently attached to the gold surface of the microfabricated electrodes and were used for the sensitive detection of A. salmonicida. The antibody-antigen immunoreaction was studied by enzyme-linked immunosorbent assay (ELISA), and the surface functionalization was characterized by using quartz crystal microbalance (QCM), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). The performance of the developed immunosensor, in terms of sensitivity, repeatability, and specificity, was also studied. The linear working range varied between 1 and 107 CFU mL-1, with a limit of detection (LOD) as low as 1 CFU mL-1. The suitability of the immunosensor for real sample detection was successfully demonstrated via recovery studies performed in spiked seawater samples. The proposed technology supports the use of low-cost and portable instrumentation that concedes the ultrasensitive, simple, and fast quantification of the A. salmonicida. To the best of our knowledge, this is the first portable sensing system for the detection of A. salmonicida in seawater samples, which provides a promising online monitoring platform for the detection of this bacterium in aquaculture facilities.

The trend of services provided by human milk banks between 2010 and 2019 in Brazil.

OBJECTIVE: To describe the trend of participation in group and individual support by human milk banks (HMBs) provided between 2010 and 2019 in Brazil. METHODS: Ecological study with data from participation in group and individual support provided by the HMBs between 2010 and 2019, available in the production report of the Brazilian Network of Human Milk Banks. The number of participation in group and individual support was expressed for Brazil and for Brazilian macroregions in absolute numbers. Trend analysis was performed from the analysis of index numbers, considering the year 2010 as a reference. It was calculated the ratio of the number of participation in group and individual support by HMBs for each macroregion and year. RESULTS: There was an increase of 42% in participation in group support (300,595 in 2010 vs 425,570 in 2019) and an increase of 69% in individual support (1,157,038 in 2010 vs 1,962,162 in 2019). The North and Northeast macroregions had the highest growth rates in the provision of these services (122 and 131%, respectively), above the national growth rate in the study period. In contrast, the Midwest region showed a downward trend throughout this period, for both types of support. However, in the Midwest, there was a higher ratio of participation in groups by HMBs between 2010 and 2016 and for individual support by HMBs between 2010 and 2012. CONCLUSION: Individual and group support provided by the HMB as a strategy to support breastfeeding increased considerably in Brazil during the study period, especially in the North and Northeast regions.

Fundamentals of Biosensors and Detection Methods.

Biosensors have a great impact on our society to enhance the life quality, playing an important role in the development of Point-of-Care (POC) technologies for rapid diagnostics, and monitoring of disease progression. COVID-19 rapid antigen tests, home pregnancy tests, and glucose monitoring sensors represent three examples of successful biosensor POC devices. Biosensors have extensively been used in applications related to the control of diseases, food quality and safety, and environment quality. They can provide great specificity and portability at significantly reduced costs. In this chapter are described the fundamentals of biosensors including the working principles, general configurations, performance factors, and their classifications according to the type of bioreceptors and transducers. It is also briefly illustrated the general strategies applied to immobilize biorecognition elements on the transducer surface for the construction of biosensors. Moreover, the principal detection methods used in biosensors are described, giving special emphasis on optical, electrochemical, and mass-based methods. Finally, the challenges for biosensing in real applications are addressed at the end of this chapter.

Association Between Maternal Work and Exclusive Breastfeeding in Countries of Latin America and Caribbean.

OBJECTIVE: The aim of this study was to estimate the association between individual and contextual characteristics related to maternal work and exclusive breastfeeding (EBF) in Latin America and the Caribbean. METHODS: A cross-sectional study, conducted with data from the Demographic and Health Survey of Bolivia (2008), Brazil (2006), Colombia (2010), the Dominican Republic (2007), Guatemala (2015), Haiti (2017), Honduras (2011) and Peru (2011). The sample included infants who were under 6 months of age and their mothers. The outcome was EBF (yes/no), individual predictors were maternal employment status (employed/not employed), type of occupation, and type of employment (formal/informal), and contextual predictors were gross domestic product, maternity leave, and percentage of women in the labor force. The association between maternal employment status and EBF was performed using multilevel Poisson analysis adjusted for maternal education level, presence of partner, place of residence, maternal age, type of childbirth, primiparity, wealth index and breastfeeding in the first hour of life. RESULTS: The prevalence of EBF was 58.0% in Bolivia, 41.1% in Brazil, 39.2% in Colombia, 7.6% in the Dominican Republic, 50.8% in Guatemala, 39.7% in Haiti, 31.1% in Honduras, and 68.1% in Peru. The percentage of employed women ranged from 19.1% in the Dominican Republic to 46.1% in Bolivia. Maternal employment was negatively associated with EBF (Prevalence Ratio [PR] = 0.77; 95% CI 0.73, 0.82), while the highest percentage of women in the labor force of the country was positively associated with EBF (PR = 1.03; 95% CI 1.01, 1.06), with an increase in the PR value after the inclusion of gross domestic product in the model. CONCLUSIONS: The prevalence of EBF was lower in infants whose mothers were employed. However, the prevalence of EBF was higher in countries with a larger percentage of women in the labor force.

Global Health Diplomacy (GHD) and the integration of health into foreign policy: Towards a conceptual approach.

Since the end of the Cold War, health has gone from a peripheral concern in foreign policy negotiations to a prominent place on the global political agenda. While the rise of health onto the foreign policy agenda is by now old news, the driving forces behind its expansion into new political spheres remain understudied and undertheorized. This article builds on empirical findings from a four-country study of the integration of health into foreign policy, and proposes a conceptual approach to GHD to improve understanding of the conditions under which health is successfully positioned on the foreign policy agenda. Our approach consists of three dimensions: features of institutions and the interest various actors represent in GHD; the ideational environment in which GHD operates; and issue characteristics of the specific health concern entering foreign policy. Within each dimension, we identify specific variables that, in combination, make up the explanatory power of the proposed approach. The proposed approach does not relate to, or build upon, a single social sciences, public health, or international relations (IR) theory, but can be seen as a heuristic device to identify dimensions and variables that may shape why certain health issues rise onto the foreign policy agenda.

18F-FDG PET/CT in Late Acquisition Identifies Sites of Active Disease in Treated Takayasu Arteritis.

OBJECTIVE: Few studies have taken advantage of 18F-fluorodeoxyglucose positron emission tomography associated with computed tomography (18F-FDG PET/CT) to personalize patient evaluation and identify sites of more active disease in Takayasu arteritis (TA)-treated patients. This study aimed to evaluate the utility of 18F-FDG PET/CT in late acquisition in identifying sites of active disease in patients under full treatment for TA. METHODS: In this cross-sectional study, patients under full treatment underwent whole-body 18F-FDG PET/CT. Sites of increased 18F-FDG uptake were classified by a score of 3 on the visual scale using the liver uptake as reference. A quantitative analysis was also performed by measuring the maximum standardized uptake value (SUV) of the vascular wall of affected arteries. Disease activity using the National Institutes of Health criteria was also evaluated. RESULTS: Of the 20 patients, there were 18 female and 2 male patients, with a mean age of 43.6 (±11.58) years and a disease duration of 8.3 (±6.25) years. Thirteen participants (65%) were in inflammatory activity according to the criteria proposed by the National Institutes of Health. All patients received immunosuppressive agents, and one of them received immunobiological treatment. The highest SUV value was 6.2 in the aortic arch, and the lowest was 1.0 in the subclavian artery. The mean maximum SUV did not differ between clinically active and inactive patients. In the visual analysis, all participants had at least 1 vascular site with inflammatory activity, with an uptake ≥2 in relation to the liver. The aortic arch was the most frequently involved site. CONCLUSIONS: This study showed that 18F-FDG PET/CT in late acquisition is an effective imaging method to assess TA activity even in fully treated patients.

Horta comunitária e Psicologia Social: um relato de experiência / Community garden and social psychology: an experience report

A experiência profissional aqui relatada se refere à prática de estágio supervisionado em Psicologia Social e Comunitária, desenvolvida no ano de 2017, junto a um grupo intergeracional de horta comunitária. O trabalho foi realizado em uma instituição de assistência social de um município do interior do estado de São Paulo. Tendo por objetivo promover o desenvolvimento humano e fomentar a formação grupal entre seus participantes, as atividades práticas desenvolvidas na horta foram entendidas e organizadas como atividades-meio para a promoção do desenvolvimento e constituição grupal. O grupo intergeracional realizou ao longo do ano mais de trinta encontros semanais nos quais, além das atividades práticas na horta, também ocorreram rodas de conversa, discussão de curtas metragens, dinâmicas grupais, dentre outras. Destacamos como principais resultados desta intervenção entre os participantes do grupo: a aprendizagem de variadas técnicas de cultivo; o fortalecimento das relações interpessoais entre si; o desenvolvimento da autonomia e auto-organização do coletivo; e a constituição deste como importante rede de apoio para seus integrantes.(AU)

The professional experience reported refers to the practice of supervised internship in Social and Community Psychology, developed in 2017, with an intergenerational community garden group. The work was carried out in a social assistance institution in a municipality in the interior of the state of São Paulo. With the objective of promoting human development and fostering group formation among its participants, the practical activities developed in the garden were understood and organized as means-activities to promote group development and constitution. Over the course of the year, the intergenerational group held more than thirty weekly meetings in which, in addition to practical activities in the garden, there were also conversation circles, discussion of short films, group dynamics, among others. We highlight as main results of this intervention observed among the group members: the learning of various cultivation techniques; the strengthening of interpersonal relationships; the development of group autonomy and self-organization; and its constitution as an important support network for its members.(AU)

La experiencia profesional aquí relatada se refiere a la práctica de pasantía supervisada en Psicología Social y Comunitaria, desarrollada en 2017, con un grupo intergeneracional de huerta comunitaria. El trabajo fue realizado en una institución de asistencia social de un municipio del interior del estado de São Paulo. Con el objetivo de promover el desarrollo humano y promover la formación de grupos entre sus participantes, las actividades prácticas desarrolladas en el jardín fueron entendidas y organizadas como medios-actividades para la promoción del desarrollo y constitución de grupos. A lo largo del año, el grupo intergeneracional realizó más de treinta encuentros semanales en los que, además de actividades prácticas en el jardín, también hubo ruedas de conversación, discusión de cortometrajes, dinámicas de grupo, entre otros. Destacamos como principales resultados de esta intervención entre los participantes del grupo: el aprendizaje de diferentes técnicas de cultivo; el fortalecimiento de las relaciones interpersonales entre ellos; el desarrollo de la autonomía colectiva y la autoorganización; y su constitución como una importante red de apoyo para sus miembros.(AU)

Perfil epidemiológico dos casos notificados de sífilis materna e congênita em uma maternidade referência em Belo Horizonte / Epidemiological profile of the reported cases of maternal and congenital syphilis in a reference maternity hospital from Belo Horizonte

Introdução: A sífilis é uma doença infectocontagiosa causada pela bactéria Treponema pallidum, com transmissão predominantemente sexual. Nas gestantes não tratadas ou tratadas de forma inadequada, a infecção ocorre por via transplacentária. Objetivos: Traçar o perfil epidemiológico dos casos de sífilis materna e congênita. Métodos: Estudo transversal, descritivo e quantitativo realizado através do acesso aos casos notificados de sífilis no período de janeiro a junho de 2020, em uma maternidade referência em assistência materno-infantil em Belo Horizonte, Minas Gerais. Resultados: Foram identificados 232 casos notificados de sífilis congênita neste período e a prevalência da doença foi de 4,3%. Entre as gestantes, 69% possuem 20 a 34 anos, 14,65% ensino fundamental completo e 43,1% são de raça parda. Quanto aos casos de transmissão vertical, 87,5% realizaram pré-natal, 23,3% obtiveram diagnóstico de sífilis no momento do parto e em 15,1% houve tratamento concomitante do parceiro. Conclusão: Na maternidade estudada é elevada a prevalência da sífilis congênita. Os resultados demonstram a necessidade de melhoria no controle da sífilis na gestação.

Introduction: Syphilis is an infectious contagious disease caused by bacterium Treponema pallidum, with predominantly sexual transmission. In untreated or inadequately treated pregnant women, the infection occurs transplacentally. Purpose: To trace the epidemiological profile of the maternal and congenital syphilis cases. Methods: A cross-sectional, descriptive and quantitative study conducted through access to the syphilis cases reported from January to June 2020, in a maternity hospital that is a reference in maternal and childcare in Belo Horizonte, Minas Gerais. Results: A total of 232 reported cases of congenital syphilis were identified in this period and the prevalence of the disease was 4.3%. Among the pregnant women, 69% are aged between 20 and 34 years old, 14.65% have complete elementary school, and 43.1% are brown-skinned. As for the cases of vertical transmission, 87.5% attended prenatal care, 23.3% were diagnosed with syphilis at the time of delivery and, in 15.1% there was concomitant treatment of the partners. Conclusion: In the maternity hospital under study, the prevalence of congenital syphilis is high. The results show the need for improvement in the control of syphilis during pregnancy

Processo de passagem de plantão: o olhar de enfermeiras nas unidades de terapia intensiva / Procedimiento de paso de guardia: la mirada de las enfermeras en las unidades de cuidados intensivos / Procedure for the handover: nurses' perspective in intensive care units

Objetivo: compreender o processo de passagem de plantão das enfermeiras nas Unidades de Terapia Intensiva Adulto. Método: estudo com abordagem qualitativa, cuja coleta de dados foi realizada entre outubro e dezembro de 2020, por meio de observação não participativa e entrevista semiestruturada realizada em cinco unidades intensivas de hospital público do estado da Bahia, Brasil. Resultados: emergiram duas categorias principais: Práxis da passagem de plantão para melhoria do cuidado e Barreiras que prejudicam a comunicação durante a passagem de plantão. Foi possível compreender o processo de passagem de plantão, com base nos olhares das enfermeiras intensivistas, as quais dispõem de elementos estruturais para comunicação efetiva que reverberam na continuidade da assistência. Considerações finais: no processo de passagem de plantão das enfermeiras, condições estruturais e ambientais, tais como conversas paralelas, dispersão, falta de atenção, interrupções, saídas antecipadas e ruídos foram caracterizadas como barreiras que causavam falhas e interferiam no processo de comunicação.

Objetivo: comprender el proceso de paso de guardia de las enfermeras en las Unidades de Terapia Intensiva Adulto. Método: estudio con enfoque cualitativo, cuya recopilación de datos fue realizada entre octubre y diciembre de 2020, por medio de observación no participativa y entrevista semiestructurada realizada en cinco unidades intensivas de hospital público del estado de Bahía, Brasil. Resultados: surgieron dos categorías principales: Praxis del paso de guardia para mejora del cuidado y Barreras que perjudican la comunicación durante el paso de guardia. Fue posible comprender el proceso de paso de guardia, con base en las miradas de las enfermeras intensivistas, las cuales disponen de elementos estructurales para comunicación efectiva que reverberan en la continuidad de la asistencia. Consideraciones finales: en el proceso de paso de guardia de las enfermeras, condiciones estructurales y ambientales, tales como conversaciones paralelas, dispersión, falta de atención, Las interrupciones, salidas anticipadas y ruidos fueron caracterizadas como barreras que causaban fallas e interferían en el proceso de comunicación.

Objective: to understand the process of handover of nurses in Adult Intensive Care Units. Method: study with a qualitative approach, whose data collection was performed between October and December 2020, through non-participant observation and semi-structured interview conducted in five intensive care units of a public hospital in the state of Bahia, Brazil. Results: two main categories emerged: Praxis of the handover to improve care and barriers that impair communication during the handover. It was possible to understand the process of shift, based on the looks of intensive nurses, which have structural elements for effective communication that reverberate in the continuity of care. Final considerations: in the process of handover of nurses, structural and environmental conditions, such as parallel conversations, dispersion, lack of attention, interruptions, anticipated egress and noise were characterized as barriers that caused failures and interfered in the communication process.

Correction: A novel microfluidic system for the sensitive and cost-effective detection of okadaic acid in mussels.

Correction for 'A novel microfluidic system for the sensitive and cost-effective detection of okadaic acid in mussels' by Ana Castanheira et al., Analyst, 2021, 146, 2638-2645, DOI: 10.1039/D0AN02092C.

Recent Advances on Photoinduced Cascade Strategies for the Synthesis of N-Heterocycles.

Over the last decade, visible-light photocatalysis has proved to be a powerful tool for the construction of N-heterocyclic frameworks, important constituents of natural products, insecticides, pharmacologically relevant therapeutic agents and catalysts. This account highlights recent developments and established methods towards the photocatalytic cascades for preparation of different classes of N-heterocycles, giving emphasis on our contribution to the field.