RESUMO
El trauma ha recibido una gran atención en los últimos años. Una línea de trabajo en el tema ha consistido en analizar la importancia de las variables personales en la resistencia y vulnerabilidad ante el trauma (Figley, 1995) y, como consecuencia, el efecto que dicho trauma tiene sobre el profesional (Stamm, 2003). Este trabajo empírico examina, en una muestra de 419 profesionales sanitarios, el papel de determinadas variables de personalidad (empatía, comprensibilidad, reto y sentido del humor) como moderadoras en la relación entre determinadas variables laborales (tarea traumática y sobrecarga laboral) y el cambio de creencias y valores sobre el mundo (Janoff-Bulman, 1992). La medida del síndrome se realiza a partir del Cuestionario de Estrés Traumático Secundario (Moreno et al., 2004). Los resultados indican que tales variables de personalidad parecen desempeñar un importante papel en el proceso de sacudida de creencias. Finalmente, la discusión enfatiza la necesidad de centrar la atención en la interacción entre los factores de personalidad y las demandas laborales y contextuales para avanzar en la compresión del proceso del trauma en trabajadores de emergencias
Trauma has received a great deal of attention in recent years. One line of research in this field focuses on the importance of personality variables in the resistance and vulnerability to trauma (Figley, 1995) and on the consequences of trauma on emergency professionals (Stamm, 2002). The purpose of this study was to examine in a sample of 419 emergency professionals the role of several personality variables (empathy, comprehensibility, challenge and sense of humor) as moderators of the relationship between job demands (traumatic task and overload) with shattered assumptions (Janoff-Bulman, 1992). Secondary traumatic stress was measured with measured with Secondary Traumatic Stress Measure (Moreno et al., 2004). Results indicate these personality variables seem to have an important role in the change of assumptions process. Finally, further implications of the finding are discussed
Assuntos
Humanos , Transtornos de Estresse Pós-Traumáticos/psicologia , Pessoal de Saúde/psicologia , Assistência Ambulatorial , Avaliação em SaúdeRESUMO
BACKGROUND AND OBJECTIVES: The positive regulatory domain I (PRDM1) protein or BLIMP-1, belonging to the PRDM gene family of transcriptional repressors, is a key regulator of terminal differentiation in B-lymphocytes and is critical for plasma cell differentiation. DESIGN AND METHODS: Here we document the expression of PRDM1 in normal and neoplastic lymphoid cells, through the use of a monoclonal antibody that recognizes the molecule in paraffin-embedded tissue sections. A large series of B and T-cell lymphomas (679 cases) was studied, using tissue microarrays. RESULTS: Multiple myeloma, plasmacytoma and lymphoplasmacytic lymphoma cases (n=19) were positive. Plasmablastic lymphoma, oral mucosa-type (n=15), were also found to be positive. PRDM1 protein was expressed in some cases of B-cell neoplasia, i.e. chronic lymphocytic leukemia/small lymphocytic lymphoma (15%), diffuse large B-cell lymphoma (43%), classical Hodgkin's lymphoma (41%) and also in T-cell lymphoma (23%). INTERPRETATION AND CONCLUSIONS: Most B-neoplastic cells showing plasmablastic differentiation were PRDM1-positive. Unexpectedly, a subset of diffuse large B-cell lymphoma expressed PRDM1, lacked detectable plasmablastic or immunoblastic changes and displayed more aggressive behavior, with a shorter failure-free survival. In contrast to normal B-cells, diffuse large B-cell lymphoma cases with increased PRDM1 expression co-expressed BCL-6 and MUM1/IRF4, confirming that PRDM1 expression in these tumors is insufficient to drive the full genetic program associated with plasmacytic differentiation.
