Assuntos
Transplante de Medula Óssea , Mobilização de Células-Tronco Hematopoéticas , Transplante de Células-Tronco Hematopoéticas , Argentina , Mobilização de Células-Tronco Hematopoéticas/métodos , Mobilização de Células-Tronco Hematopoéticas/normas , Humanos , Estudos Multicêntricos como Assunto , Inquéritos e QuestionáriosRESUMO
OBJECTIVE: To evaluate in a multivariate analysis the prognostic factors associated with hematopoietic recovery and the supportive care requirements after autotransplant of progenitor cells (PC) from various sources: bone marrow (BMPC), BMPC & peripheral blood (PBPC), and PBPC alone. PATIENTS AND METHODS: A total of 570 patients with hematological malignancies and solid tumors underwent high-dose therapy followed by autotransplant. PBPC were obtained after mobilization with chemotherapy and/or cytokines. One-hundred five patients received BMPC, 217 received BMPC & PBPC and 248 PBPC alone; all of the patients received G-CSF or GM-CSF after infusion. RESULTS: In a multivariate analysis the recovery of neutrophils was adversely associated with low numbers of nucleated cells infused (P < 0.13), bone marrow progenitor cell source, and diagnosis of multiple myeloma and acute leukemia (P < 0.001). The factors that adversely affected platelet recovery were low number of nucleated cells and diagnosis of multiple myeloma and acute leukemia (P < 0.001). CONCLUSIONS: We conclude that BMPC adversely affect neutrophil recovery while low numbers of nucleated cells and diagnosis of multiple myeloma and acute leukemia adversely affect both neutrophil and platelet recovery.
Assuntos
Transplante de Medula Óssea , Células Precursoras Eritroides , Neoplasias Hematológicas/terapia , Transplante de Células-Tronco Hematopoéticas , Adolescente , Adulto , Idoso , Transplante de Medula Óssea/métodos , Criança , Pré-Escolar , Intervalo Livre de Doença , Estudos de Avaliação como Assunto , Feminino , Sobrevivência de Enxerto , Neoplasias Hematológicas/diagnóstico , Neoplasias Hematológicas/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Prognóstico , Análise de Regressão , Estudos Retrospectivos , Taxa de Sobrevida , Transplante AutólogoRESUMO
As part of our investigations on fluorine containing compounds of potential pharmacological interest, a series of N-substituted p-fluorobenzencarboxyamides, analogs of previously studied p-fluorobenzensolfonamides, was prepared. The in vitro antibacterial and antimycotic properties were also assayed. The replacement of the sulfonamide group with an isosteric carboxyamide one, was found to confer to trifluoromethylsubstituted compounds good activity against some strains of yeasts (Candida) and hyphomycetes (Tricophyton, Aspergillus, Microsporum, Epidermophyton). These compounds however are not very active against the gram-positive and gram-negative bacteria on which the corresponding sulfonanilides showed significant activity.
Assuntos
Anti-Infecciosos/síntese química , Bactérias/efeitos dos fármacos , Fluorbenzenos/síntese química , Fungos/efeitos dos fármacos , Antibacterianos , Antifúngicos/síntese química , Benzamidas/síntese química , Benzamidas/farmacologia , Fenômenos Químicos , Química , Fluorbenzenos/farmacologia , Testes de Sensibilidade MicrobianaRESUMO
Further pharmacological (antipyretic and analgesic activities) and physicochemical (pka and relative lipophilicity) studies are reported on some trifluoroacetanilides which have preliminary revealed promising activities in the animal models of acute and chronic inflammation, in analogy with the known antiinflammatory trifluoromethanesulfonanilides.
Assuntos
Acetanilidas/síntese química , Analgésicos/síntese química , Anti-Inflamatórios não Esteroides/síntese química , Anti-Inflamatórios/síntese química , Acetanilidas/farmacologia , Animais , Fenômenos Químicos , Físico-Química , Flúor/síntese química , Flúor/farmacologia , Concentração de Íons de Hidrogênio , Lipídeos , Masculino , Camundongos , Ratos , SolubilidadeRESUMO
In an extension of the investigations on fluorine derivatives of potential pharmacological interest, some new p-fluorobenzensulfonanilides were synthesized and screened in vitro against many species of Gram-positive and Gram-negative bacteria and against some strains of Candida albicans. Some of these compounds exhibited significant antibacterial activity. The relation between activity and structure revealed that the presence of chloro and trifluoromethyl groups in the aniline ring increases activity against Gram-positive bacteria. The acute toxicity in mice was also determined.
Assuntos
Anti-Infecciosos/síntese química , Fluorbenzenos/síntese química , Sulfonamidas/síntese química , Animais , Antibacterianos , Candida albicans/efeitos dos fármacos , Fenômenos Químicos , Química , Feminino , Fluorbenzenos/farmacologia , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Dose Letal Mediana , Masculino , Camundongos , Testes de Sensibilidade Microbiana , Sulfonamidas/farmacologiaRESUMO
The analogy with the anti-inflammatory trifluoromethane-sulfonanilides prompted us to the synthesis of a series of trifluoroacetanilides which were found to maintain the pharmacological properties of the analog sulfonanilides. Many of the obtained compounds inhibited either the carrageenin-induced rat paw edema and the adjuvant-induced arthritis; some showed better anti-inflammatory properties than indomethacin and phenylbutazone. Acute toxicity and ulcerogenic effects were significantly lower than those of reference drugs.
