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Parasitol Res ; 107(2): 381-8, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20467753

RESUMO

Nosemosis, a disease caused by a microsporidian infection, is one of the most frequently observed parasitic pathologies affecting adult honeybees. Presently, Nosema ceranae seems to be the main microsporidian infection in Apis mellifera. The antibiotic fumagillin is the only compound available to treat Nosema diseases; however, it is no longer licensed in most EU member states; therefore, the need to identify new molecules/substances prevails. The intent of this paper is to test bacterial metabolites by Bacillus and Enterococcus strains, isolated from bee midgut and honey. The toxicity on bees and the antiparasitic activity on N. ceranae were assessed under laboratory conditions. Results did not yield toxicity for the administered surfactin or bacteriocin concentrations. Spores exposed to direct contact with a particular surfactin revealed a significant infectivity reduction when inoculated on bees. This surfactin, administered ad libitum from the individuals' emergence, led to a significant reduction in parasitosis development when bees were infected with untreated spores 7 days postemergence. Based on the results obtained, one of the surfactins is herein postulated as a molecule capable of reducing N. ceranae development, acting either by direct exposure to purified spores or incorporated into the digestive tract of the bee.


Assuntos
Antifúngicos/farmacologia , Bacillus/química , Abelhas/efeitos dos fármacos , Enterococcus/química , Lipopeptídeos/farmacologia , Nosema/efeitos dos fármacos , Peptídeos Cíclicos/farmacologia , Animais , Antifúngicos/isolamento & purificação , Antifúngicos/toxicidade , Bacillus/isolamento & purificação , Abelhas/microbiologia , DNA Fúngico/química , DNA Fúngico/genética , Enterococcus/isolamento & purificação , Trato Gastrointestinal/microbiologia , Lipopeptídeos/isolamento & purificação , Lipopeptídeos/toxicidade , Dados de Sequência Molecular , Peptídeos Cíclicos/isolamento & purificação , Peptídeos Cíclicos/toxicidade , Análise de Sequência de DNA
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