RESUMO
We found in the literature 119 cases of pheochromocytoma manifested during pregnancy and observed 2 personal cases. Pheochromocytoma and pregnancy show reciprocal influences. Unsuspected diagnosis is frequent and followed by a high maternal mortality. The tumor was surgically removed in 42 cases. There are two different attitudes: when diagnosed in early pregnancy, the tumor can be excised without delay although the foetal risk is high; when the diagnosis is made in the last trimester, foetal maturity has to be awaited to perform a combined caesarean section and excision of the tumor.
Assuntos
Neoplasias das Glândulas Suprarrenais/cirurgia , Feocromocitoma/cirurgia , Complicações na Gravidez/cirurgia , Neoplasias das Glândulas Suprarrenais/mortalidade , Adulto , Cesárea , Feminino , Humanos , Feocromocitoma/mortalidade , Gravidez , Complicações na Gravidez/mortalidade , PrognósticoRESUMO
After a brief review of the biochemistry of the renin-angiotensin system (R. A. S.) components and of their pharmacological inhibitors, the authors describe the main biological effects of angiotensins. A particular emphasis is given to the synergistic effects of the sympathetic nervous system and of the R. A. S., and their major influence on the regulation of hydromineral metabolism and blood pressure. The methods developed for the study of R. A. S. are critically described. Finally, the most important clinical indications of the study of R. A. S. activity are given, and a special attention is paid to the conditions in which such a study must be developed in humans.