RESUMO
The effects of ointment containing king crab (Paralithodes camtschatica) collagenase on intact skin, thermal, and pyonecrotic wounds were studied in rats by using hematological, biochemical, immunological, and morphological methods. The ointment for the skin and viscera was shown to be safe. It is highly effective in debriding the infected wounds. Different concentrations of collagenase were tested. The concentration of collagenase was recommended to be 0.2 mg/g ointment for use.
Assuntos
Anti-Infecciosos Locais/administração & dosagem , Braquiúros/enzimologia , Colagenases/administração & dosagem , Cicatrização/efeitos dos fármacos , Animais , Anti-Infecciosos Locais/efeitos adversos , Anti-Infecciosos Locais/isolamento & purificação , Colagenases/efeitos adversos , Colagenases/isolamento & purificação , Modelos Animais de Doenças , Masculino , Pomadas , Ratos , Ratos Endogâmicos Lew , Segurança , Resultado do Tratamento , Infecção dos Ferimentos/tratamento farmacológico , Infecção dos Ferimentos/patologiaAssuntos
Anti-Infecciosos/farmacologia , Braquiúros/enzimologia , Colagenases/farmacologia , Cicatrização/efeitos dos fármacos , Animais , Anti-Infecciosos/administração & dosagem , Anti-Infecciosos/uso terapêutico , Colagenases/administração & dosagem , Colagenases/uso terapêutico , Masculino , Necrose , Pomadas , Infecções por Pseudomonas/tratamento farmacológico , Infecções por Pseudomonas/patologia , Ratos , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/patologia , Infecção dos Ferimentos/tratamento farmacológico , Infecção dos Ferimentos/patologiaRESUMO
The development of emotional pain stress in rats is accompanied by an increase in lipid peroxidation (LPO) products in the pancreas and a decrease in antiradical activity of its lipids. Hypoinsulinemia, of which a degree of expression is inversely proportional to an increase in peroxidation products, is observed. Antioxidant administration prevents LPO process activation in the pancreas and inhibits, to a great extent, a decrease in the level of insulin in stress. It is assumed that a certain role in the development of hypoinsulinemia in stress can be played by LPO processes resulting in the formation of active forms of oxygen and damage of the islands of Langerhans of B-cells.