Exploring the psychometric properties of Gujarati version of WHOQOL-BREF scale among general population of Western Gujarat: A confirmatory factor analysis.

Background: Quality of life (QOL) is a useful component in assessing the health of people and society. There are many reports on the validity of the four-domain structure of the World Health Organization Quality of Life-BREF (WHOQOL-BREF), but few studies have investigated the possibility of a better alternative model fit among the general population. Objective: The objectives of the study were to perform exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) using the WHOQOL-BREF and to generate a model that fits among the general population of western Gujarat. Materials and Methods: A community-based cross-sectional study was conducted from September 2022 to February 2023 using the Gujarati version of the WHOQOL-BREF questionnaire among the general population of urban and rural areas. Factor analysis was performed to check the model fit. Results: Factor analysis gave a five-factor structure, and the CFA suggested that the model was acceptable. Conclusion: Based on the findings, this model can better explain QOL and can be used as a reliable and valid instrument for evaluating QOL in the general population of Gujarat.

A Retrospective Analysis of Clinico-Demographic and Genetic Characteristics and Treatment Outcomes in Isoniazid Mono-Resistant Tuberculosis Patients: A Single-Center Study.

INTRODUCTION: Treatment failure and relapse rates are more likely to occur when there is isoniazid (INH) resistance. So, we can no longer ignore the problem of isoniazid mono-resistance. It is pertinent to control the spread of primary INH resistance and prevent secondary resistance. AIM: This study aims to evaluate subjects' clinical, demographic, and genetic characteristics and explore their treatment outcomes. METHODS: All data of isoniazid mono-resistant tuberculosis (TB) patients, which were maintained in the electronic database of mandatory notifications (NIKSHAY Portal) between 2017 and 2022, were reviewed. A total of 54 patients were included after excluding five patients with ongoing treatment. RESULTS: Of 54 patients, 41 (75.9%) were cured, which was classified under favorable outcome, and the rest were classified under unfavorable outcome. Phenotypic, high-level mutation (katG) was found in 48 (88.9%) patients. Kaplan-Meier curves show that survival probabilities increase in weeks with regular intake of drugs. CONCLUSION: Our study found that those with younger ages and males were more affected. We found favorable outcomes in the majority of patients.