RESUMO
Carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) levels in serum and urine from 25 patients with bladder cancer and 42 patients with cancer of the renal pelvis/ureter have been evaluated as an aid for clinical diagnosis of urothelial cancer. The tumour CEA content varied markedly, from values obtained in normal urothelium up to 822 and 7306 ng/g wet tissue in cancer of the renal pelvis/ureter and bladder cancer, respectively. Serum and urine CEA levels were found not to correlate with the tumour CEA content. Serum CEA levels were found increased over 5 microg/L in up to 16% of bladder cancer patients, but only in 4.8% in renal pelvis/ureter cancer. Urine of cancer patients contained usually normal CEA levels. Increased serum TPA levels were found in 48% and 35.7% of patients with bladder cancer and cancer of renal pelvis/ureter, respectively. Urine TPA levels were significantly increased in both, patients with bladder cancer (p<0.001) and cancer of renal pelvis/ureter (p<0.01). The median values of urine TPA were 59, 1095 and 1325 U/L, in controls, patients with bladder cancer and cancer of renal pelvis/ureter, respectively. However, considering previously described increase of TPA in inflammatory diseases of urinary tract and in renal failure patients, results of urinary TPA obtained in the diagnostic workup of urothelial cancer should be cautiously interpreted. This study shows that serum and urine levels of CEA and TPA have no diagnostic accuracy required for clinical diagnosis of urothelial cancer.
Assuntos
Antígeno Carcinoembrionário/metabolismo , Carcinoma de Células de Transição/diagnóstico , Neoplasias Renais/diagnóstico , Antígeno Polipeptídico Tecidual/metabolismo , Neoplasias Ureterais/diagnóstico , Neoplasias da Bexiga Urinária/diagnóstico , Carcinoma de Células de Transição/metabolismo , Diagnóstico Diferencial , Humanos , Neoplasias Renais/metabolismo , Pelve Renal , Radioimunoensaio , Reprodutibilidade dos Testes , Neoplasias Ureterais/metabolismo , Neoplasias da Bexiga Urinária/metabolismo , Urotélio/metabolismo , Urotélio/patologiaRESUMO
The interaction between reserpine and nonsteroidal anti-inflammatory agents ( NSAIA ) in producing experimental gastric ulcers was studied in rats. The ulcerating effects of reserpine, indomethacin, ketoprofen and phenylbutazone were found to be dose-dependent. The area of gastric mucosal lesions was highly significantly increased if NSAIA were injected intraperitoneally 3 min after reserpine. Reserpine and NSAIA in doses which by themselves did not produce gastric mucosal damage, induced gastric ulcers in all experimental animals when injected simultaneously.