RESUMO
A short biographical abstract of Painter Velázquez and his artistical and cultural background with relation to this own time is given. His whole work and of the court and official jobs he had has, been analysed. Together with his artistical vocation and great capacity and aptitude for painting, he felt the ambition to seek a position of nobility. A peculiar research of the pathological aspects appearing in his pictures has been made, regardless of the technical characteristics of his painting and style. For this purpose, his paintings have been classified in still lives, religious pictures, mythological pictures, portraits of royal male and female family members, portraits of ordinary people, big peoples such as Las Lanzas, Las Hilanderas and Las Meninas, etc., to conclude with the really singular group of buffoons, dwarfs, jesters and mad people. The pathological issues have been commented. A list of bibliographical references is also added.
Assuntos
Medicina nas Artes , Pinturas/história , Nanismo , Feminino , História do Século XVII , Humanos , Masculino , EspanhaRESUMO
The HENE-OX system (isoforms 1, 2 and 3) is the key enzyme in the oxygen dependent HEME catabolism pathway and cleavage to HEME into biliverdin IX alfa, iron and carbon-monoxide (CO). The biliverdin reductase catalyzes biliverdin into bilirubin unconjugated what is converted in bilirubin conjugated, mono and biglucuronized for the activity of hepatic Uridindifosfo-glucuronil-transferase (UDFGT). The hyperbilirubinemias unconjugated can produce kernicterus. This should be treated with metalloporphyrins (Zn-Proto IX, Zn-Mesoporphyrin, Sn-Proto-IX, Sn-Mesoporphyrin). Relations between HEM-OX/CO and NOS/NO systems. The induction of the HEME-OX system is a protective cellular mechanism against oxidative damage. Studies about the relations of the HEME-OX system with functions of various tissues (liver, kidney, cardiovascular and respiratory and hematological system, etc.).
