1.
Bioorg Med Chem Lett
; 9(18): 2767-72, 1999 Sep 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10509932
RESUMO
Modeling of neutral or mildly basic functional groups in the S1 site of thrombin led to the targeting of imidazole as a S1 binding element and correctly predicted the optimal chain length for connecting this group with the S2 and S3 binding elements. Derivatives of 4-(3-aminopropyl)-imidazole can be selective inhibitors of thrombin demonstrating potent anticoagulant activity.