RESUMO
An 11-year-old girl presented in autumn with an asymptomatic rash on her arms, face, and legs of a 3-week duration. What is your diagnosis?
Assuntos
Exantema , Dermatopatias Genéticas , Criança , Humanos , Eritema/diagnóstico , Eritema/etiologia , Dermatopatias Genéticas/diagnósticoRESUMO
Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis with variable clinical features. The classic presentation is an ulceration with an erythematous to violaceous undermined border. Extracutaneous manifestations may occur. Associated systemic diseases include inflammatory bowel disease, inflammatory arthritides, and hematologic disorders. The pathophysiologic mechanism of disease is not completely known but likely related to the cumulative impact of inflammation, immune-mediated neutrophilic dysfunction, and genetic predisposition. Incidence is between 3 and 10 people per million but may be greater due to under recognition. In this article, we will discuss the diagnostic criteria, disease subtypes, systemic associations, and workup.
Assuntos
Doenças Inflamatórias Intestinais , Pioderma Gangrenoso , Humanos , Pioderma Gangrenoso/diagnóstico , Pioderma Gangrenoso/complicações , Inflamação/complicações , Doenças Inflamatórias Intestinais/complicações , Doenças Inflamatórias Intestinais/diagnóstico , Diagnóstico DiferencialRESUMO
This case report describes erythematous patches on the face that involved the nasolabial folds, as well as numerous skin-colored homogenous waxy papules on the arms, neck, and trunk.
Assuntos
Mucinoses , Escleromixedema , Humanos , Escleromixedema/diagnóstico , Mucinoses/diagnósticoAssuntos
Dermatomiosite , Psoríase , Anticorpos Monoclonais Humanizados/uso terapêutico , Dermatomiosite/complicações , Dermatomiosite/tratamento farmacológico , Método Duplo-Cego , Humanos , Psoríase/complicações , Psoríase/tratamento farmacológico , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Numerous drugs have been linked to the induction or exacerbation of systemic cutaneous lupus erythematosus (SCLE). This report presents the third case of the biologic abatacept as an exacerbating medication for SCLE. A 73-year old woman with a remote history of subacute cutaneous lupus and rheumatoid arthritis, well controlled on hydroxychloroquine, presented with worsening annular erythematous, slightly scaly plaques on her forearms and hands. She had been started on abatacept a month prior. She was diagnosed with SCLE exacerbated by abatacept given the clinical findings, time course, and skin biopsy with interface dermatitis. Her skin eruption cleared completely several months later after discontinuing abatacept and switching to tociluzumab, while remaining on hydroxychloroquine. This case highlights the need to consider abatacept as a potential exacerbating medication for SCLE in any patient with a new photodistributed papulosquamous eruption.
Assuntos
Abatacepte/efeitos adversos , Artrite Reumatoide/tratamento farmacológico , Inibidores de Checkpoint Imunológico/efeitos adversos , Lúpus Eritematoso Cutâneo/induzido quimicamente , Idoso , Anticorpos Monoclonais Humanizados/uso terapêutico , Biópsia , Substituição de Medicamentos , Feminino , Seguimentos , Humanos , Lúpus Eritematoso Cutâneo/diagnóstico , Pele/patologia , Resultado do Tratamento , Suspensão de TratamentoAssuntos
Lúpus Eritematoso Discoide/complicações , Transtornos de Fotossensibilidade/diagnóstico , Pele/patologia , Luz Solar/efeitos adversos , Atrofia/diagnóstico , Atrofia/etiologia , Atrofia/patologia , Biópsia , Face , Feminino , Humanos , Lúpus Eritematoso Discoide/imunologia , Lúpus Eritematoso Discoide/patologia , Transtornos de Fotossensibilidade/imunologia , Transtornos de Fotossensibilidade/patologia , Pele/imunologia , Pele/efeitos da radiação , Adulto JovemRESUMO
Unilateral hyperhidrosis of neurological origin has been associated with head trauma, cerebral palsy, spinal cord injury, peripheral neuropathy, lesions of the hypothalamus, and cerebral or brainstem strokes. In this report, we describe a 61-year-old man with isolated sweating on the left side of his entire body. A right-sided brainstem meningioma producing mass effect is suspected as the underlying etiology.