[Skin lipids in seborrhea- and sebostasis-associated skin diseases]. / Hautlipide bei mit Seborrhoe-und Sebostase-assoziierten Hauterkrankungen.

Recent studies suggest that epidermal skin lipids play an important role in the pathogenesis of skin diseases associated with seborrhoea or sebostasis. Depending on the state of the skin, various lipids are found in varying quantities and proportions. In some sebostatic diseases, in particular, altered enzyme activities relevant to the synthesis of lipids have been identified, which may account for alterations in epidermal lipid fractions. This concept represents a substantial modification of earlier ones, according to which sebostatic or seborrhoeic skin diseases were attributed solely to decreased or increased sebum lipids, respectively. This provides an important rationale for a new approach to the therapy of certain skin diseases with specific lipid fractions, such as ceramides.

[The effect of cosmetics and dermatologic agents on skin lipids]. / Einfluss von Kosmetika und Dermatika auf die Hautlipide.

The composition of stratum corneum lipids and of sebum lipids is described with respect to their biological function, with special reference to dry skin. In this context, we discuss desiccation and lipid removal by surfactants and the protective and refatting effects of oil bath products and other lipid-containing preparations for topical use.

[Tendon sheath fibroma. A case report with immunohistochemical studies]. / Das Sehnenscheidenfibrom. Ein Fallbericht mit immunhistochemischen Untersuchungen.

This report describes a 50-year-old male patient with fibroma of tendon sheath. The tumour had grown rapidly, and clinical examination of it led to the suspicion of a giant cell tumour of tendon sheath and a vascular glomus tumour. Microscopical investigation then allowed diagnosis of the tumour as a fibroma of tendon sheath, which was characterized by spindle-shaped and stellate-shaped fibroblasts, a fibrocollagenous, partly myxoid stroma, and slit-like vessels. Immunohistochemically, most tumour cells expressed vimentin and smooth muscle actin, but not desmin. Thus, fibroma of tendon sheath can be regarded as a synovial tumour with myofibroblastic differentiation. Histologically, fibroma of tendon sheath must be differentiated from other tumours, such as giant cell tumour of tendon sheath and histiocytoma, but also from nodular fasciitis and sarcomas.

[Spinocellular cancers and myxoid atypical fibroxanthoma of an actinically damaged burn scar]. / Spinozelluläre Karzinome und myxoides atypisches Fibroxanthom auf aktinisch geschädigter Verbrennungsnarbe.

We report on a 66-year-old male patient suffering from several squamous cell carcinomas and a myxoid atypical fibroxanthoma of the skin. The tumours developed in burn scars that the patient had had for more than 50 years and that had in part undergone actinic elastosis. The role of burn scars in the development of different skin tumours is pointed out. In addition, we discuss the differential diagnosis of the rare myxoid variant of atypical fibroxanthoma.