1.
Bioorg Med Chem Lett
; 20(10): 3155-7, 2010 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20399648
RESUMO
Inspired by natural product, LL-Z1640-2, clinical candidate, E6201 (22) was discovered in a medicinal chemistry effort through total synthesis. The modification on C14-position to N-alkyl substitution showed to be potent in vitro and orally active in vivo in anti-inflammatory assays.