RESUMO
Temafloxacin, a new fluoroquinolone with broad-spectrum anti-bacterial activity and a favourable pharmacokinetic profile, was evaluated in a prospective, randomized double-blind multicentre study in which 564 patients were enrolled. Ambulatory adults with lower respiratory tract infections were randomly assigned to receive temafloxacin 600 mg or ciprofloxacin 750 mg, each given every 12 h for 7-14 days. Cure or improvement occurred in 93.8% of temafloxacin patients and 93.1% of ciprofloxacin recipients (P greater than 0.05). Bacteriological eradication rates were higher in the temafloxacin group than in the ciprofloxacin group (99.5% vs 92.5%; P = 0.001) primarily because of the failure of ciprofloxacin to eradicate Streptococcus pneumoniae (P = 0.01). Both regimens were well tolerated. In patients who received concomitant theophylline, gastrointestinal and central nervous system disturbances occurred in a higher percentage of patients in the ciprofloxacin group than the temafloxacin group (36.4% vs 9.4%; P less than 0.05). This study indicates that temafloxacin would be suitable for the empirical treatment of lower respiratory tract infections, including high-risk groups such as the elderly and heavy smokers.
Assuntos
Anti-Infecciosos/uso terapêutico , Ciprofloxacina/uso terapêutico , Fluoroquinolonas , Quinolonas/uso terapêutico , Infecções Respiratórias/tratamento farmacológico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anti-Infecciosos/efeitos adversos , Bactérias/efeitos dos fármacos , Ciprofloxacina/efeitos adversos , Método Duplo-Cego , Interações Medicamentosas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Quinolonas/efeitos adversos , Infecções Respiratórias/microbiologia , Teofilina/uso terapêuticoRESUMO
The outcome of 664 pregnancies in 297 Jamaican women with homozygous sickle cell (SS) disease over the period 1959-1984 was reviewed. Overall, the spontaneous abortion rate was 118 per 1000 pregnancies, the stillbirth rate 128 per 1000 births, and perinatal mortality 171 per 1000 births. There was a striking secular increase in both spontaneous abortions and stillbirths which was accounted for, in part, by a trend for abortions to increase with maternal age up to the age of 30 years, a greater proportion of patients in the high-risk 25-29 year age group occurring in the 1980-1984 period. Another factor contributing to the poor obstetric performance in the 1980-1984 period was probably an increased survival and pregnancy rate in high-risk patients. Seven women had pregnancy-related deaths giving a pregnancy mortality rate of 1.1%.
Assuntos
Anemia Falciforme/complicações , Doença da Hemoglobina SC/complicações , Complicações na Gravidez/etiologia , Adulto , Feminino , Morte Fetal , Humanos , Mortalidade Infantil , Jamaica , Mortalidade Materna , Gravidez , PrognósticoRESUMO
The outcome of 664 pregnancies in 297 Jamaican women with homozygous sickle cell (SS) disease during the period 1959-84 was reviewed. Overall, the spontaneous abortion rate was 118/1000 pregnancies, the stillbirth rate 128/1000 births, and perinatal mortality 171/1000 births. There was a striking secular increase in both spontaneous abortions and stillbirths accounted for, in part, by a trend for abortions to increase with maternal age up to the age of 30, a greater proportion of patients in the high-risk group, ages 25-29, occuring during 1980-84. Another factor contributing to the poor obstetric performance during the 1980-84 period was probably an increased survival and pregnancy rate in high-risk patients. 7 women had pregnancy-related deaths giving a pregnancy mortality rate of 1.1 percent.(AU)
