1.
Chemistry
; 20(38): 12051-5, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25088810
RESUMO
By introducing a disposable activating substituent at C-3, the asymmetric 1,4-addition to a notoriously unreactive 2-substituted chromenone was achieved with high levels of (2R)-stereoselectivity in the presence of a chiral Cu(I)-phosphoramidite complex as a catalyst. This paved the way for an efficient and conceptually novel synthesis of (R,R,R)-α-tocopherol from readily available starting materials.