Semi-uniform stability of operator semigroups and energy decay of damped waves.

Only in the last 15 years or so has the notion of semi-uniform stability, which lies between exponential stability and strong stability, become part of the asymptotic theory of C0-semigroups. It now lies at the very heart of modern semigroup theory. After briefly reviewing the notions of exponential and strong stability, we present an overview of some of the best known (and often optimal) abstract results on semi-uniform stability. We go on to indicate briefly how these results can be applied to obtain (sometimes optimal) rates of energy decay for certain damped second-order Cauchy problems. This article is part of the theme issue 'Semigroup applications everywhere'.

[Standards for treatment in forensic committment according to § 63 and § 64 of the German criminal code : Interdisciplinary task force of the DGPPN]. / Standards für die Behandlung im Maßregelvollzug nach §§ 63 und 64 StGB : Interdisziplinäre Task-Force der DGPPN.

People who have been convicted of a crime due to a severe mental disorder and continue to be dangerous as a result of this disorder may be placed in a forensic psychiatric facility for improvement and safeguarding according to § 63 and § 64 of the German Criminal Code (StGB). In Germany, approximately 9000 patients are treated in clinics for forensic psychiatry and psychotherapy on the basis of § 63 of the StGB and in withdrawal centers on the basis of § 64 StGB. The laws for treatment of patients in forensic commitment are passed by the individual States, with the result that even the basic conditions differ in the individual States. While minimum requirements have already been published for the preparation of expert opinions on liability and legal prognosis, consensus standards for the treatment in forensic psychiatry have not yet been published. Against this background, in 2014 the German Society for Psychiatry and Psychotherapy, Psychosomatics and Neurology (DGPPN) commissioned an interdisciplinary task force to develop professional standards for treatment in forensic psychiatry. Legal, ethical, structural, therapeutic and prognostic standards for forensic psychiatric treatment should be described according to the current state of science. After 3 years of work the results of the interdisciplinary working group were presented in early 2017 and approved by the board of the DGPPN. The standards for the treatment in the forensic psychiatric commitment aim to initiate a discussion in order to standardize the treatment conditions and to establish evidence-based recommendations.

Prolonged Mechanical Ventilation After Lung Transplantation-A Single-Center Study.

This single-center study examines the incidence, etiology, and outcomes associated with prolonged mechanical ventilation (PMV), defined as time to definite spontaneous ventilation >21 days after double lung transplantation (LTx). A total of 690 LTx recipients between January 2005 and December 2012 were analyzed. PMV was necessary in 95 (13.8%) patients with decreasing incidence during the observation period (p < 0.001). Independent predictors of PMV were renal replacement therapy (odds ratio [OR] 11.13 [95% CI, 5.82-21.29], p < 0.001), anastomotic dehiscence (OR 8.74 [95% CI 2.42-31.58], p = 0.001), autoimmune comorbidity (OR 5.52 [95% CI 1.86-16.41], p = 0.002), and postoperative neurologic complications (OR 5.03 [95% CI 1.98-12.81], p = 0.001), among others. Overall 1-year survival was 86.0% (90.4% for LTx between 2010 and 2012); it was 60.7% after PMV and 90.0% in controls (p < 0.001). Conditional long-term outcome among hospital survivors, however, did not differ between the groups (p = 0.78). Multivariate analysis identified renal replacement therapy (hazard ratio [HR] 3.55 [95% CI 2.40-5.25], p < 0.001), post-LTx extracorporeal membrane oxygenation (HR 3.47 [95% CI 2.06-5.83], p < 0.001), and prolonged inotropic support (HR 1.95 [95% CI 1.39-2.75], p < 0.001), among others, as independent predictors of mortality. In conclusion, PMV complicated 14% of LTx procedures and, although associated with increased in-hospital mortality, outcomes among patients surviving to hospital discharge were unaffected.

[Richard Strauß: a contribution on the occasion of his 150th birthday from an urological point of view]. / Richard Strauß: Ein Beitrag zu seinem 150. Geburtstag aus urologischer Sicht.

Richard Strauß is one of the most important composers of the first half of the 20th century. In this article, his life is represented with special emphasis on the points of contact with urology and on the field of conflict of the time. We give a detailed description of the composer's urological illness, which finally lead to his death. The last works of the master, composed at the beginning and during his last illness, are appreciated as touching creations of his parting. Finally, we compare the treatment of the prominent patient with the contemporary level of urology.

[Evaluation of outpatient aftercare of forensic patients (§ 63 StGB) in North Rhine-Westphalia, Germany]. / Evaluation der ambulanten Nachsorge forensischer Patienten (§ 63 StGB) in Nordrhein-Westfalen.

BACKGROUND: The quality and success of the aftercare treatment of forensic patients (§ 63 StGB, Penal Code) are not only of concern to therapists and law courts dealing with the question of potentially dangerous behavior; apart from politicians and the general public it is also a matter of interest for workers in general and community psychiatry. METHODS: In an evaluation of forensic patients who were discharged from confinement (§§ 67d 2, 6 and 67b StGB) into aftercare treatment between 2002 and 2006 in North Rhine-Westphalia, it was possible to collect data on recidivism from a total of 225 patients after an average follow-up period of 4.4 years. Apart from gathering statistics concerning case history, diagnosis, offence committed and resulting confinement, a dynamic analysis of how they coped in differing day to day situations was carried out with 115 of the discharged patients. RESULTS: The frequency of offence recidivism by patients who were professionally accompanied throughout the aftercare period was significantly lower in comparison to earlier studies (without specialist supervision), particularly the number of sexual offences and violent crimes (7 from 225 - 3.1 %) were noticeably reduced. By comparing patients who reoffended with those showing socially acceptable behavior it was possible to determine specific features of protection and risk characteristics. CONCLUSIONS: Low offence recidivism indicated a high degree of aftercare effectiveness but there is room for improvement and further development in the existing system. The postdischarge prognosis factors and the typical pitfalls found in the study should be adequately taken into account in order to improve risk management in the aftercare setting and therefore subsequently ameliorate the chances of discharge for long neglected problematic patient groups, in particular patients with personality disorders involved in sexual offences.

[August Gottlieb Richter: urological aspects of his comprehensive operative and scientific work]. / August Gottlieb Richter: Die urologischen Aspekte seines umfangreichen operativen und wissenschaftlichen Werkes.

August Gottlieb Richter (1742-1812) was one of the most distinguished surgeons in the second half of the eighteenth century. In this article his life and scientific career during an age shaken by wars and radical changes are described. Particular attention is paid to his achievements as a doctor, teacher and scientific author. The latter activity finds its foremost expression in the"Chirurgische Bibliothek" ("Surgical library"), a practice-oriented scientific journal, as well as in his later work"Anfangsgründe der Wundarzneykunst" ("Elements of wound surgery"). This article concentrates on the urological aspects of his work and compares these aspects with contemporary publications. Particular emphasis is placed on Richter's dispute about fashionable medical trends typical for that era as well as his culture of criticism and self-criticism.

Quantitative analysis of victim demographics and injury characteristics at a metropolitan Medico-Legal Center.

For the timeframe of February 1st, 2003 until December 31st, 2005, all forensic medical experts at the Medico-Legal Center of the Institute of Legal Medicine in Hamburg, Germany, completed a standardized questionnaire for every consenting surviving violence victim (n=2733) age 14 and older. Central to the quantitative analysis of the data collected was the extraction of specific injury characteristics from the sample population. A correlation was demonstrated between injury typologies and four possible perpetrator-victim constellations, each of which was subcategorized into sexual and non-sexual assaults.

Cortical infarction following cardiosurgical procedures - air embolism as a probable cause.

BACKGROUND: Focal neurological deficits following cardiopulmonary bypass surgery are usually thought to be the result of embolic stroke. Computed tomography (CT) is sometimes negative although severe deficits persist. OBJECTIVES: To describe a syndrome consisting of reduced postoperative vigilance, frequent epileptic seizures and focal neurological deficits in the presence of an apparently normal CT scan and often isolated cortical infarction on magnetic resonance imaging (MRI). METHODS: We retrospectively collected data on all patients fulfilling the above-mentioned criteria, seen for neurological examination by the consultant between 2002 and 2006 in our heart center. RESULTS: We found 39 patients, nearly all of whom had cortical hyperintense lesions on diffusion-weighted MRI in the right hemisphere with corresponding left-sided hemiparesis. Early seizures occurred in 31 patients. Clinical outcome was heterogeneous. CONCLUSIONS: Predominance of right hemisphere involvement and lesion pattern in MRI make air embolism the most probable cause for this postoperative syndrome.

[Patients with schizophrenia in forensic-psychiatric hospitals (section 63 German Penal Code) in North Rhine-Westphalia]. / Schizophrene Patienten im psychiatrischen Massregelvollzug (S63 StGB) Nordrhein-Westfalens.

The aim of our study was to determine the development of the number of patients with schizophrenia in detention (section 63 German Penal Code) in North Rhine-Westphalia and the characterization of these patients. Patients with schizophrenia are examined, by using a standardized questionnaire answered by the attending psychiatrist or psychologist (n = 531). During the last 12 years the number of patients with schizophrenia in forensic-psychiatric hospitals has increased three times, whereas the number of patients with other diagnoses heightened only twofold. The patients with schizophrenia showed high rates of psychiatric comorbidities (substance disorders 73.9 %, personality disorders 17.2 %), previous inpatient treatments (78.3 % with a mean of 7.5 stays) and previous convictions (63.4 %). Almost half of these convictions (46.6 %) were violent offences (e. g. assault, homicide). Possible explanations for this development are discussed.

Cerebral network deficits in post-acute catatonic schizophrenic patients measured by fMRI.

Twelve patients with catatonic schizophrenia and 12 matched healthy controls were examined with functional MRI while performing a motor task. The aim of our study was to identify the intracerebral pathophysiological correlates of motor symptoms in catatonic patients. The motor task included three conditions: a self-initiated (SI), an externally triggered (ET) and a rest condition. Statistical analysis was performed with SPM5. During the self-initiated movements patients showed significantly less activation than healthy controls in the supplementary motor area (SMA), the prefrontal and parietal cortex. Our results suggest a dysfunction of the "medial motor system" in catatonic patients. Self-initiated and externally triggered movements are mediated by different motor loops. The "medial loop" includes the SMA, thalamus and basal ganglia, and is necessary for self-initiated movements. The "lateral loop" includes parts of the cerebellum, lateral premotor cortex, thalamus and parietal association areas. It is involved in the execution of externally triggered movements. Our findings are in agreement with earlier behavioral data, which show deficits in self-initiated movements in catatonic patients but no impairment of externally triggered movements.

Initial experience with the medtronic ADVANTAGE valve prosthesis in the mitral position--clinical outcome and analysis of complications.

OBJECTIVE: The Medtronic ADVANTAGE prosthetic heart valve is a bileaflet mechanical heart valve which has two main design modifications. The prosthesis has an enlarged central orifice to improve blood flow characteristics and an asymmetric butterfly pivot recess with expanded outflow component designed to enhance the blood flow washing through the pivot region. This report summarizes the initial experience with 55 patients who underwent isolated mitral valve replacement. METHODS: We prospectively followed 55 patients undergoing mitral valve replacement with the Medtronic ADVANTAGE prosthesis in a single center study. All patients were operated on via a median sternotomy and a left atrial approach. RESULTS: The age of the patients at implant ranged from 42 years to 77 years with a mean of 61.8 years. Forty-five percent of the patients were male. Seventy-five percent of the patients were in NYHA functional class III or IV prior to valve replacement. The diameters of the implanted prostheses were as follows: 25 mm in 2 patients, 27 mm in 12 patients, 29 mm in 20 patients, and 31 mm in 21 patients. Coronary artery bypass grafting was performed with valve replacement in 16.4 % of patients and additional tricuspid repair in 10.9 %. After one year, 97.6 % and after two years 100 % of the included patients were in NYHA functional class I or II. All patients had Coumadin (warfarin) therapy postoperatively with a target INR range of 2.5 to 3.5, or 3.0 to 4.0. There were 4 thromboembolic events (7.3 %) in the early period and 2 late events (2.6 %). Episodes of valve thrombosis were not seen during the follow-up, which consisted of 76.5 patient years. The hemodynamic performance was favorable and within clinically acceptable ranges. The incidence of valve-related mortality and morbidity in this preliminary study was extremely low, indicating good clinical results comparable to those reported for other bileaflet valves. CONCLUSION: The ADVANTAGE valve is a safe and effective option for mitral valve replacement with a very low incidence of valve-related complications.

[Can neurological soft signs (NSS) contribute to the prediction of dangerousness in mentally disordered offenders?]. / Leisten neurological soft signs (NSS) einen Beitrag zur Gefährlichkeitseinschätzung psychisch kranker Straftäter gemäss 63 StGB?

The prediction of dangerousness in mentally disordered offenders is still as well complex as insufficiently empirically proven. So far more or less valid criteria for predicting recidivism have been determined concerning historical and clinical aspects. Whereas biological, neurological and neuropsychological variables that could be of importance for the development of chronic delinquent behavior have mostly been neglected. This article deals with the relevance of neurological soft signs (NSS) for the prediction of dangerousness in mentally ill offenders as one possible factor in a multidimensional model. 155 patients were examined after a minimum time at risk of 2 years (mean 4 years). The results showed that on the one hand there is no relevant and valid connection between neurological soft signs and recidivism for the general heterogeneous group of forensic patients. On the other hand similar results arose for the subgroup of patients with a personality disorder without intellectual deficits as for the homogeneous group of offenders in prisons. Therefore a significant meaning of NSS for certain subgroups can be presumed.

Subgaleal hematoma in child abuse.

The mother brought her 31/2-year-old son to a paediatric clinic as his forehead was swollen and bluish in appearance. She was unable to give any explanation for this lesion. Clinically it was noted that a very visible and also palpable, doughy swelling was present both in the forehead as well as the hard skull areas. Some hours later, a massive bilateral periocular haematoma appeared. Whilst X-rays were unable to provide any diagnostic help, the sonographic examination of the skull carried out on the same day revealed an extensive subgaleal haematoma. This phenomenon is described in radiological literature as "scalping" and is caused by the use of considerable, blunt violence against the head (shear stresses, e.g. by pulling at the hair). The mother's boyfriend later confessed forceful pulling of the hair.

Risk assessment of sexual offenders in German forensic institutions.

BACKGROUND: The assessment of recidivism in sexual offenders is an urgent topic for forensic psychiatry in Germany. The call for useful predictive measures is therefore getting louder. AIMS: The present study analyses which criteria are employed by therapists in forensic hospitals to assess the dangerousness of sexual offenders. Of particular interest is whether the criteria listed in presently known prediction scores as decisive are actually used in decision-making in current forensic psychiatric practice. METHOD: Data are collected in a prospective prediction study funded by the German Research Association. RESULTS: The results reveal that therapists employ mainly clinical and less historical criteria, thus indicating substantial differences from currently known prediction scores and results of other studies. CONCLUSIONS: That therapists base their prediction of dangerousness primarily on clinical variables reveals a substantial error that has to be remedied. Further research on the extent of relevance of clinical variables is needed.

[Preliminary recidivism rates of the Essener prognosis study]. / Aktuelle Rückfalldaten der Essener prospektiven Prognosestudie. Werden Deliktrückfälle forensischer Patienten ((section sign) 63 StGB) seltener?

The prediction of dangerousness in mentally disordered offenders -- and here mainly the issue of safety -- is still of primary interest for forensic experts and the public. The effectiveness of treatment and therefore of the whole German forensic system is generally measured by recidivism rates of this clientele. This article presents topical recidivism rates of 255 mentally ill offenders after a minimum time at risk of 2 years (mean 4 years). Data are collected in the Essener prospective multicenter study funded by the German research association which began in 1997 and in which 23 forensic hospitals in Germany took part. Main objective of the study is the determination of valid criteria for predicting recidivism of mentally disordered offenders. Currently the rates for general recidivism are 21.6 % and for severe reoffences 7.5 % which are in comparison to other recent studies relatively low.

INR self-management permits lower anticoagulation levels after mechanical heart valve replacement.

BACKGROUND: The Early Self Controlled Anticoagulation Trial (ESCAT I) showed that anticoagulation self-management after mechanical heart valve replacement decreased complication rates by maintaining INR levels closer to the target range than International Normalized Ratio (INR) home doctor management. The therapeutic range for the INR in that study was between 2.5 and 4.5 for all positions of prosthetic valves. ESCAT II should find out whether lowering the target range for INR self-management would further reduce complication rates. METHODS: ESCAT II is a prospective controlled randomized (valves: St. Jude Medical Standard or Medtronic Hall, treatment: conventional/low-dose) multicenter study with 3,300 patients. We present interim results of 1,818 patients. 908 were categorized as having a low-dose target range, which was INR 1.8 to 2.8 for prostheses in aortic position and 2.5 to 3.5 for prostheses in mitral position or in combined valve replacement. The control group (conventional group) with 910 patients aimed at an INR of 2.5 to 4.5 for all valve positions. RESULTS: In the conventional group, 74% of INR values measured were within the therapeutic range. In the low-dose group, 72% of the values were within that range. The linearized thromboembolism rate (% per patient year) was 0.21% for both groups. The bleeding complication rate was 0.56% in the low-dose regimen group versus 0.91% in the conventional group. CONCLUSIONS: Early onset INR self-management under oral anticoagulation after mechanical heart valve replacement enables patients to keep within a lower and smaller INR target range. The reduced anticoagulation level resulted in fewer grade III bleeding complications without increasing thromboembolic event rates.

[The release of forensic patients (63 StGB) and the problem of predicting dangerousness]. / Zur momentanen Entlassungssituation forensischer Patienten (section 63 StGB) und zur Problematik der Gefährlichkeitsprognose. Erste Ergebnisse einer prospektiven Prognosestudie.

This article presents first results of a prospective prediction study with participation of twenty-three forensic institutions from seven states of FRG. Main objective of this study is the determination of valid criteria for predicting recidivism of mentally disordered offenders. This evaluation (n = 188) investigates which patients are presently released from forensic institutions. In comparison to previous studies the releases per annum have decreased significantly. In the last two years there has been an increase in release of schizophrenic patients and a decrease in release of patients with a personality disorder and sexual offenders. In addition it has been analyzed which criteria therapists use to predict dangerousness from a clinical point of view.

[INR self-management after mechanical heart valve replacement: ESCAT (Early Self-Controlled Anticoagulation Trial)]. / INR-Selbstmanagement nach mechanischem Herzklappenersatz: ESCAT (Early Self-Controlled Anticoagulation Trial).

Severe thromboembolic and hemorrhagic complications following mechanical heart valve replacement essentially occur due to intense oral anticoagulation and fluctuating individual INR values around the target range. INR self-management can help to minimize these fluctuations. Beginning this therapeutic control immediately after mechanical heart valve replacement further reduces anticoagulant-induced complications. Included in the study were 1200 patients. The quality of oral anticoagulation also improved through INR self-management. Over an observation period of two years, nearly 80% of INR values recorded by the patients themselves were within the target therapeutic range of 2.5-4.5. This corresponds to a high significance of p < = 0.001 in favor of INR self-management. Only 64.9% of INR values monitored by family practitioners were within the desired range. The results differed slightly in quality between patient groups with different levels of training (comprehensive, secondary modern, grammar with or without university). Of patients trained in INR self-management following mechanical heart valve replacement, 91.7% maintained their competence in this technique throughout the entire follow-up period. Only 8.3% of those trained immediately after surgery were unable to continue with INR self-management.

[INR Self-management after mechanical heart valve replacement: ESCAT (Early Self-Controlled Anticoagulation Trial)]. / INR-Selbstmanagement nach mechanischem Herzklappenersatz: ESCAT (Early Self-Controlled Anticoagulation Trial).

Severe thromboembolic and hemorrhagic complications following mechanical heart valve replacement essentially occur due to intense oral anticoagulation and fluctuating individual INR values around the target range. INR self-management can help to minimize these fluctuations. Beginning this therapeutic control immediately after mechanical heart valve replacement further reduces anticoagulant-induced complications. Included in the study were 1200 patients. The quality of oral anticoagulation also improved through INR self-management. Over an observation period of two years, nearly 80 % of INR values recorded by the patients themselves were within the target therapeutic range of 2.5-4.5. This corresponds to a high significance of p < = 0.001 in favor of INR self-management. Only 64.9 % of INR values monitored by family practitioners were within the desired range. The results differed slightly in quality between patient groups with different levels of training (comprehensive, secondary modern, grammar with or without university). Of patients trained in INR self-management following mechanical heart valve replacement, 91.7 % maintained their competence in this technique throughout the entire follow-up period. Only 8.3 % of those trained immediately after surgery were unable to continue with INR self-management.