Oral lead bullet fragment exposure in northern bobwhite (Colinus virginianus).

Lead (Pb) is a worldwide environmental contaminant known to adversely affect multiple organ systems in both mammalian and avian species. In birds, a common route of exposure is via oral ingestion of lead particles. Data are currently lacking for the retention and clearance of Pb bullet fragments in gastrointestinal (GI) tract of birds while linking toxicity with blood Pb levels. In the present study, northern bobwhite quail fed a seed-based diet were orally gavaged with Pb bullet fragments (zero, one or five fragments/bird) and evaluated for rate of fragment clearance, and changes in peripheral blood, renal, immune, and gastrointestinal parameters. Based on radiographs, the majority of the birds cleared or absorbed the fragments by seven days, with the exception of one five-fragment bird which took between 7 and 14 days. Blood Pb levels were higher in males than females, which may be related to egg production in females. In males but not females, feed consumption, body weight gain, packed cell volume (PCV), plasma protein concentration, and δ-aminolevulinic acid dehydratase (δ-ALAD) activity were all adversely affected by five Pb fragments. Birds of both sexes that received a single Pb fragment displayed depressed δ-ALAD, suggesting altered hematologic function, while all birds dosed with five bullet fragments exhibited greater morbidity.

Lead pellet retention time and associated toxicity in northern bobwhite quail (Colinus virginianus).

Birds are exposed to Pb by oral ingestion of spent Pb shot as grit. A paucity of data exists for retention and clearance of these particles in the bird gastrointestinal tract. In the current study, northern bobwhite quail (Colinus virginianus) were orally gavaged with 1, 5, or 10 Pb shot pellets, of 2-mm diameter, and radiographically followed over time. Blood Pb levels and other measures of toxicity were collected, to correlate with pellet retention. Quail dosed with either 5 or 10 pellets exhibited morbidity between weeks 1 and 2 and were removed from further study. Most of the Pb pellets were absorbed or excreted within 14 d of gavage, independent of dose. Pellet size in the ventriculus decreased over time in radiographs, suggesting dissolution caused by the acidic pH. Birds dosed with one pellet showed mean blood Pb levels that exceeded 1,300 µg/dl at week 1, further supporting dissolution in the gastrointestinal tract. Limited signs of toxicity were seen in the one-pellet birds; however, plasma δ-aminolevulinic acid dehydratase (d-ALAD) activity was persistently depressed, suggesting possible impaired hematological function.

Evaluation of nonsurgical treatment of atlantoaxial subluxation in dogs: 19 cases (1992-2001).

OBJECTIVE: To evaluate long-term neurologic outcome in dogs with atlantoaxial subluxation (AAS) that were treated nonsurgically with a cervical splint. DESIGN: Retrospective study. ANIMALS: 19 dogs with AAS and managed with a cervical splint. PROCEDURE: Medical records from 2 university hospitals were reviewed. Information pertaining to trauma, duration of clinical signs prior to admission, medical treatments prior to admission, results of neurologic and physical examinations at the time of admission, results of laboratory testing, results of diagnostic imaging, neurologic status at the time of discharge, duration of time the cervical splint was used for treatment, and neurologic status at the time of splint removal and at a final reexamination was extracted from the medical records. Long-term outcome was defined as neurologic status greater than or equal to 1 year after splint removal. Factors associated with a good or poor long-term outcome were determined. RESULTS: A good final outcome was reported in 10 of 16 dogs. Median duration of clinical signs prior to referral was 30 days; dogs that were affected < or = 30 days were significantly more likely to have a good long-term outcome, compared with dogs affected > 30 days. The neurologic grade at admission, radiographic appearance of the dens, age at onset of clinical signs, and history were not associated with outcome. CONCLUSIONS AND CLINICAL RELEVANCE: Nonsurgical management of AAS by use of a cervical splint is a viable treatment modality for young dogs with a first episode of acute-onset clinical signs, regardless of the severity of neurologic deficits at admission.

Gastric outflow obstruction after ingestion of wood glue in a dog.

A 2-year-old, male, mixed-breed dog presented with a 12-day history of vomiting, depression, and weight loss after ingestion of industrial-strength wood glue containing diphenylmethane diisocyanate as its active ingredient. A diagnosis of gastric foreign body was made from survey abdominal radiographs. A large aggregate of solidified wood glue was surgically removed, and the dog recovered uneventfully. Fourteen other cases have been reported to the Animal Poison Control Center at the American Society for the Prevention of Cruelty to Animals (ASPCA). Eight of those 14 cases required surgical intervention. All cases recovered completely.