RESUMO
Debido a que aproximadamente 30 por ciento de los pacientes con epilepsia o responden a los tratamientos farmacológicos con anticonvulsivantes, se hace necesaria la aplicación de otras opciones terapéuticas, tales como la cirugía, la dieta cetogénica, o la estimulación cerebral, con el fin de mejorar la calidad de vida de estos pacientes. Para lograr un mejor manejo de las crisis refractarias, se están desarrollando técnicas quirúrgicas más precisas y menos invasivas, se están implementando dietas más fáciles de seguir, con un mejor control de los efectos secundarios y se están haciendo grandes avances tecnológicos en cuanto a estimulación cerebral.
Approximately 30 percent of patients suffering of epilepsy do not respond to drug treatment with anticonvulsants,for this reason it is necessary the application of other therapeutic options such as surgery, ketogenic diet and brainstimulation in order to improve their quality of life. For this reason is important the development of new surgery techniques, more accurate and less invasive procedures, easier and safer diets, and technological advances in brain stimulation to achieve a bettermanagement of refractory epilepsy.
Assuntos
Humanos , Cirurgia Geral , Epilepsia , Dieta , NeurologiaRESUMO
Functional magnetic resonance imaging (fmri) is a non-invasive functional brain mapping technique ased on blood oxygenated level dependent signal (BOLD). It is obtained during T2* weighted imaging MRI studies. fmri aids in the localization of language and motor function for patients candidates for epilepsy surgery, and has up to a 90% concordance with WADA test. Even though synchronous recording of fmri and EEG is technically challenging, it shows a discordant pattern of activation when compared with EEG or electrocorticography. This finding could be due to complex epileptic networks, and overall this study technique has the potential to contribute to further research into epileptic network and epilepsy physiopathology.