RESUMO
Nasal mucous velocity was estimated by following the motion of radiopaque discs of Teflon by means of a fluoroscopic image intensifier. From 5 to 10 discs were deposited on the superior surface of the inferior turbinate with a forceps. No local anesthesia was employed and the subjects experienced no discomfort. The linear velocity of the discs was obtained by playing the videotape onto a television monitor, measuring distance with a ruler, and dividing by elapsed time. Duplicate runs of 1-2 min, 15 min apart were very reproducible but runs at 4-h intervals or daily over a 5-day period had a coefficient of variation of 30%. Average nasal velocity for individual ranged from 0 to 22.5 mm/min and group means ranged from 6. 8 to 10.8 mm/min. There was no statistically significant difference in nasal mucous velocity between young and elderly subjects nor was there a sexual difference. The saccharin test of nasal mucous transport was unsatisfactory because of inability to repeat the test more often than 1-2 h and its propensity to produce mild discomfort in a significant number of subjects. Saccharin times did not correlate significantly with values of nasal mucous velocity.
Assuntos
Muco/fisiologia , Nariz/diagnóstico por imagem , Adulto , Fatores Etários , Idoso , Transporte Biológico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Muco/metabolismo , Mucosa Nasal/metabolismo , Politetrafluoretileno , Radiografia , Sacarina , Tecnologia RadiológicaAssuntos
Asma/tratamento farmacológico , Terbutalina/uso terapêutico , Administração Oral , Resistência das Vias Respiratórias/efeitos dos fármacos , Criança , Relação Dose-Resposta a Droga , Feminino , Volume Expiratório Forçado , Hemodinâmica/efeitos dos fármacos , Humanos , Medidas de Volume Pulmonar , Masculino , Terbutalina/administração & dosagem , Terbutalina/efeitos adversos , Terbutalina/farmacologiaAssuntos
Brônquios/ultraestrutura , Traqueia/ultraestrutura , Adulto , Idoso , Animais , Cílios/ultraestrutura , Cães , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Muco/fisiologia , ReologiaRESUMO
Mucociliary transport and the percentage of ciliated cells were studied in large and intermediate sized airways (generations 0-3) of anesthetized mongrel dogs before and after aminophyllin administration. The mean percentage of ciliated cells decreased respectively from 22.0% and 25.4% in the trachea and main bronchi to 8.0% in the lobar and 2.7% in the segmental bronchi. The fastest mean mucous velocity was found in the trachea (4.9 mm/min, S.E. 1.0). Mucous velocity decreased 38% from the trachea to the main bronchi, 55% to the lobar bronchi, and 66% to the segmental bronchi. A positive correlation (r = 0.75) was demonstrated between mucous velocity and the percentage of ciliated cells. After aminophyllin administration, mucous velocity increased 59% in the trachea and 27% in the main bronchi. No statistical difference in mucous velocity could be demonstrated in the smaller airways after aminophyllin, probably due to relative insensitivity of the method in short bronchi with low mucous velocities.