Relationship between Osteopontin and Bone Mineral Density.

Recent studies suggest that osteopontin (OPN) could be used as an early marker for the diagnosis of bone disorders. Considering the contradictory opinions in the literature, the objective of this systematic review is to analyse the current information regarding the relationship between OPN and bone mineral density (BMD), which represents an important process in the development of osteoporosis. We performed a literature search of clinical trials using the PubMed database, published between 1999-2020, and identified 7 studies that were eligible for analysis. The eligibility criteria were based on studies that analysed the relationship between osteopontin and bone mineral density on human subjects. Conclusion: serum OPN levels might be used as a biomarker of the early diagnosis of osteoporosis in postmenopausal women, with or without osteoporotic vertebral fractures.

Assessement by laser Doppler of the peripheral tumour perfusion after radiofrequency ablation for colorectal liver mestasis--experimental study.

Colorectal cancer became one of the most frequent malignant conditions of the past two decades. Non-resecable liver metastases might be destroyed in situ by radiofrequency although the local recurrence is still very important. Laser-Doppler flowmetry has proved to be a simple technique for monitoring the microcirculation, hereby the tissue perfusion at the edge of the post radiofrequency necrosis. The aim of the study was to evaluate microcirculation using lasser-Doppler for hepatic tissue and peripheral tumour perfusion after radiofrequency and the influence of local temperature increasing at 42 degrees C on tissular perfusion. Colorectal adenocarcinoma (CC531s) was used for liver tumour inoculationin on 15 Wag/Rij rats. Twenty-one days after inoculation, perfusion in hepatic tissue, on the tumour before and after radiofrequency treatment was mesured. When hepatic tissue was heated at 42 degrees C there was an increase in tissular perfusion, on the other part, heating the tumoural tissue do not increase perfusion. After radiofrequency in the periphery of necrosis the perfusion was still present, despite a clear drop towards initial level. Assessing the local microcirculation and tissue temperature during RF ablation by Laser-Doppler might be useful not only for RF efficiency evaluation but also as an indication for associating adjuvant local chemotherapy.

[The allergic-reactive and encephalitogenic potential of rabies vaccines prepared from different virulent materials]. / Potentialul reactiv-alergizant si encefalitogen al vaccinurilor rabice preparate din materiale virulente deosebite.

The clinical, serologic and pathohistological study was carried out on laboratory animals inoculated with a series of rabies vaccines currently used in postinfection therapy in man and some experimental rabies vaccine variants used throughout the world, in order to estimate the reactive, allergic-inducing and encephalitogen potential of the products. The results showed that all the virulent material used in the preparation of rabies vaccines studied have an allergoencephalitogenic potential, reflected by humoral and histologic modifications, especially contraindicated being the avian rabies vaccines and those prepared from adult animal nervous material. Vaccines prepared from cell cultures, virulent brain of the neonate mouse and normal lamb present and allergoencephalitogen and neuropathogen potential that must be taken into consideration within the context of a repeated postinfection therapy. Rabies vaccines prepared from foetal brain and partial thymectomized lamb or testosterone treated lamb produce humoral and histologic alterations of low intensity.