[The effect of myelopeptides on the persistence of tick-borne encephalitis virus in monkeys]. / Vliianie mielopeptidov na persistentsiiu virusa kleshchevogo éntsefalita v organizme obez'ian.

Myelopeptides (MP), bioregulatory molecules of bone marrow origin, exert a protective effect in persistence of tick-borne encephalitis virus in cynomolgus monkeys (Macaca fascicularis). The experiments involved 32 monkeys. The effect of MP was observed after one or two subcutaneous injections in a dose of 1 mg within 1.5-2 months after virus infection. The effect consists in 25-fold reduction of the frequency of virus persistence, marked limitation of the zone of spread of the persisting virus, including the central nervous system (CNS), decrease in virulence of the persisting virus, and lack of morphological signs of progress of the pathological process in the CNS. The protective effect was also observed when the infected monkeys were treated with MP and inactivated concentrated TBE vaccine. At the same time, the vaccine alone exerted a much less marked effect on the persisting TBE virus producing only a 2-fold reduction in the frequency of persistence without limitation of the zones of virus spread. In acute TBE in BALB/c mice, the effect of MP is observed irregularly. The marked protective effect of MP in TBE virus persistence in monkeys is not associated with stimulation of humoral immunity but is mediated by other immunological mechanisms requiring further study.

[The protective properties of myelopeptides in the development of infectious processes caused by bacteria of the genus Salmonella]. / Protektivnye svoistva mielopeptidov pri razvitii infektsionnykh protsessov, vyzvannykh bakteriiami roda Salmonella.

The protective properties of myelopeptides in the development of bacterial infection in mice and young pigs, caused by S. typhimurium 415, S. cholerae-suis 1422 and 370, have been studied. Myelopeptides have been found to possess protective properties when injected into animals infected with S. typhimurium and S. cholerae-suis in lethal doses. The best protective effect (survival rate of 100%) has been achieved by the injection of myelopeptides 24 hours before challenge. Myelopeptides have also been found to promote the weight gain of young pigs infected with S. cholerae-suis.

[Antigen-specific humoral factor of the lymph nodes stimulating the activity of "silent" antibody-forming cells]. / Antigenspetsificheskii gumoral'nyi faktor limfaticheskikh uzlov, stimuliruiushchii aktivnost' "molchashchikh" antiteloobrazuiushchikh kletok.

A humoral mediator has been isolated from the population of lymph-node cells obtained at the peak of immune response. This factor facilitates the transition of "silent" antibody-forming cells into the functionally mature state. The action of this mediator is antigen-specific.

[Effect of a bone marrow stimulator of antibody producers on virus-specific antibody formation in animals infected with flaviviruses]. / Vliianie kostnomozgovogo stimuliatora antiteloprodutsentov na vyrabotku virusspetsificheskikh antitel u zhivotnykh, zarazhennykh flavivirusami.

The injection of the marrow stimulator of antibody-producing cells (SAPC) into animals infected with Japanese encephalitis and tick-borne encephalitis viruses stimulated the formation of virus-specific antibodies in the infected animals, increasing antibody production 8- to 16-fold. Such SAPC-induced stimulation of the formation of virus-specific antibodies is observed in cases of both acute and chronic virus infection. The prospects of using the preparation of SAPC are discussed.

[Effect of stimulating antibody formation under the influence of bone marrow cells in vivo]. / Effekt stimuliatsii antiteloobrazovaniia pod vliianiem kletok kostnogo mozga v sistema in vivo.

Injection of intact bone marrow cells to mice at the peak of the secondary immune response results in a 2.4-fold increase of the number of antibody-forming cells in the regional lymph node. Preliminary injection of bone marrow cells to donors of the immune lymph node cells decreases the stimulation effect of antibody formation when the lymph node cells are subsequently cultivated with the intact bone marrow cells. The data obtained demonstrate the cell interaction at the level of mature antibody producers in vivo.