Structural features of eyelid connective tissue in patients with primary open-angle glaucoma.

PURPOSE: To study the connective tissue (CT) structure of upper eyelid skin of primary open-angle glaucoma (POAG) patients. PATIENTS AND METHODS: Forty-seven patients aged 47-91 expecting blepharoplasty formed 3 groups: group 1 [16 subjects without POAG, median age 55 years (interquartile range 54-55.5)], group 2 [12 subjects without POAG, median age 73 (72-76.5)], and group 3 [(19 subjects with POAG, median age 74 (70-80.5)]. Age differences between groups 1 and 2 and groups 1 and 3 are significant (p < 0.05). Thermodynamic parameters of skin samples taken during blepharoplasty: Endothermic peak ([Formula: see text], °C) and denaturation enthalpy ([Formula: see text], J/g of dry weight) were determined using differential scanning calorimetry. RESULTS: [Formula: see text] and [Formula: see text] in groups 1-3 were, respectively, 8.41 (7.42-10.25) and 66.55 (59.9-66.7); 7.10 (5.76-10.17) and 67.35 (67.0-68.03); 11.40 (9.0-14.9) and 67.70 (67.05-68.45). [Formula: see text] differences between groups 1 and 2 are significant (p < 0.05), and Spearman's correlation between the age and [Formula: see text] is direct, medium (R = 0.638) and significant. [Formula: see text] in group 3 is significantly higher than in group 2. [Formula: see text] and [Formula: see text] in patients without POAG (groups 1 and 2) and those with POAG (group 3) are, respectively, 7.79 (6.9-10.17) and 66.6 (61.2-67,3); 11.40 (9.0-14.9); 67.7 (67.05-68.45); the respective differences are significant. CONCLUSION: Patients without POAG show a significant increase in [Formula: see text] with age, while [Formula: see text] slightly decreases. In POAG, [Formula: see text] is significantly higher and [Formula: see text] tends to grow, which may indicate structural changes in eyelid CT (collagen accumulation and cross-linking level rise). Since the upper lid is unaffected by increasing IOP directly, the changes may be viewed as manifestations of systemic CT pathology.

[Peculiarities of reactive hypertension after phacoemulsification cataract with patients of pseudoexfoliation syndrome].

Peculiarities of reactive hypertension after phacoemulsi- fication cataract with patients of pseudoexfoliation syndrome. Research was carried out on 87 designed for the surgical treatment of cataract patients (112.eyes) who were grouped according to the initial intraocular pressure (IOP), the degree of pseudoexfoliative syndrome (PES), the presence of concomitant vascular pdthology. IOP level was estimated in the first, the third day, and a month after catarditphacoemulsiication with intraocular lens implantation. It was found that the incidence of reactive hypertension in the group. ranged from 10,7 to 18,7% and correlated with the severity of the manifestations of the PES, baseline IOP and the presence of systemic cardiovascular disease. At the same time dominated by vascular factors. The results allow to identify patients with RPE included in the group of high risk of developing hypertension, reactive, and thus improve the quality -of their care and treatment.