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Behav Brain Res ; 381: 112420, 2020 03 02.
Artigo em Inglês | MEDLINE | ID: mdl-31821787

RESUMO

Neuronal calcium sensor-1 or Frequenin is a calcium sensor widely expressed in the nervous system, with roles in neurotransmission, neurite outgrowth, synaptic plasticity, learning, and motivated behaviours. Neuronal calcium sensor-1 has been implicated in neuropsychiatric disorders including autism spectrum disorder, schizophrenia, and bipolar disorder. However, the role of neuronal calcium sensor-1 in behavioural phenotypes and brain changes relevant to autism spectrum disorder have not been evaluated. We show that neuronal calcium sensor-1 deletion in the mouse leads to a mild deficit in social approach and impaired displaced object recognition without affecting social interactions, behavioural flexibility, spatial reference memory, anxiety-like behaviour, or sensorimotor gating. Morphologically, neuronal calcium sensor-1 deletion leads to increased dendritic arbour complexity in the frontal cortex. At the level of hippocampal synaptic plasticity, neuronal calcium sensor-1 deletion leads to a reduction in long-term potentiation in the dentate gyrus, but not area Cornu Ammonis 1. Metabotropic glutamate receptor-induced long-term depression was unaffected in both dentate and Cornu Ammonis 1. These studies identify roles for neuronal calcium sensor-1 in specific subregions of the brain including a phenotype relevant to neuropsychiatric disorders.


Assuntos
Comportamento de Escolha/fisiologia , Cognição/fisiologia , Potenciação de Longa Duração/genética , Proteínas Sensoras de Cálcio Neuronal/genética , Plasticidade Neuronal/genética , Neuropeptídeos/genética , Reconhecimento Psicológico/fisiologia , Animais , Ansiedade/genética , Região CA1 Hipocampal/fisiologia , Giro Denteado/fisiopatologia , Lobo Frontal/patologia , Camundongos , Camundongos Knockout , Receptores de Glutamato Metabotrópico , Filtro Sensorial/genética , Comportamento Social , Interação Social , Memória Espacial/fisiologia
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