Recommendations on the practice of calibration, dosimetry, and quality assurance for gamma stereotactic radiosurgery: Report of AAPM Task Group 178.

The American Association of Physicists in Medicine (AAPM) formed Task Group 178 (TG-178) to perform the following tasks: review in-phantom and in-air calibration protocols for gamma stereotactic radiosurgery (GSR), suggest a dose rate calibration protocol that can be successfully utilized with all gamma stereotactic radiosurgery (GSR) devices, and update quality assurance (QA) protocols in TG-42 (AAPM Report 54, 1995) for static GSR devices. The TG-178 report recommends a GSR dose rate calibration formalism and provides tabulated data to implement it for ionization chambers commonly used in GSR dosimetry. The report also describes routine mechanical, dosimetric, and safety checks for GSR devices, and provides treatment process quality assurance recommendations. Sample worksheets, checklists, and practical suggestions regarding some QA procedures are given in appendices. The overall goal of the report is to make recommendations that help standardize GSR physics practices and promote the safe implementation of GSR technologies.

Cherenkov emission-based external radiotherapy dosimetry: I. Formalism and feasibility.

PURPOSE: Cherenkov emission (CE)-based external beam dosimetry is envisioned to involve the detection of CE directly in water with placement of a high-resolution detector out of the field, avoiding perturbations encountered with traditional dosimeters. In this work, we lay out the groundwork for its implementation in the clinic and motivate CE-based dosimeter design efforts. To that end, we examine a formalism for broad-beam in-water CE-based dosimetry of external radiotherapy beams, design and test a Monte Carlo (MC) simulation framework for the calculation of CE-to-dose conversion factors used by the formalism, and demonstrate the experimental feasibility of this method. METHODS: The formalism is conceptually analogous to ionization-based dosimetry and employs CE-to-dose conversion factors, k C θ ± δ θ , including only and all CE generated within polar angles θ ± Î´Î¸ on beam axis. The EGSnrc user code SPRRZnrc is modified to calculate k C θ ± δ θ , as well as CE spectral and angular distributions. The modified code is tested with monoenergetic parallel electrons on a thin water slab. Detector configurations are examined for broad 6-22 MeV electron beams from a BEAMnrc TrueBeam model, with a focus on θ ± δ θ = 90 ∘ ± 90 ∘ (4π detection), 90 ∘ ± 5 ∘ , and 42 ∘ ± 5 ∘ ( θ = 42 ∘ is the CE angle of relativistic electrons in water). We perform a relative experimental validation at 90 ∘ with electron beams, using a simple detector design with spherical optics and geometrical optics approximation of the sensitive volume, which spans the water tank. Due to transient charged particle equilibrium, broad photon beams are generally less sensitive to beam quality, depth, and angle. RESULTS: For 0.1-50 MeV electrons on a thin water slab, the code outputs CE photon spectral density per unit mass (calculated from dose and k C θ ± δ θ ) and angle in agreement with theory within ±0.03% and ± 0 . 01 ∘ , respectively, corresponding to the output precision. The 42 ∘ configuration was found impractical due to detection considerations. Detection at 90 ∘ ± δ θ for small δθ exhibited beam quality dependence of the same order as well as strong superficial depth dependence. A 4π configuration ameliorates these effects. A more practical approach may employ a large numerical aperture. In comparing with literature, we find that these effects are less pronounced for broad photon beams in water, as expected. Measured relative k C 90 ∘ ± δ θ at small δθ were within 1% of simulated factors (relative to their local average) for percent-depth CE (PDC) >50%. At other depths, deviations were in accordance with signal-to-noise, known detector limitations, and approximations. It was found that the CE spectrum is beam quality and depth invariant, while for electron beams the CE angular distribution is strongly dependent on beam quality and depth. However, the uncertainty of CE and PDC measurement at 90 ∘ ± δ θ detection for small δθ due to ± 0 . 1 ∘ deviations around δθ was shown to be ≤1% and <0.1% (k = 1), respectively. The robustness to expected detector setup variations was found to result in ≤1% (k = 1) local uncertainty contribution for PDC >50%. CONCLUSIONS: Based on our MC and experimental studies, we conclude that the CE-based method is promising for high-resolution, perturbation-free, three-dimensional dosimetry in water, with specific applications contingent on comprehensive detector development and characterization.

Cherenkov emission-based external radiotherapy dosimetry: II. Electron beam quality specification and uncertainties.

PURPOSE: Cherenkov emission (CE) is ubiquitous in external radiotherapy. It is also unique in that it carries the promise of 3D, micrometer-resolution, perturbation-free, in-water dosimetry with a beam quality-independent detector response calibration. Our aim is to bring CE-based dosimetry into the clinic and we motivate this here with electron beams. We Monte Carlo (MC) calculate and characterize broad-beam CE-to-dose conversion factors in water for a clinically representative library of electron beam qualities, address beam quality specification and reference depth selection, and develop a preliminary uncertainty budget based on our MC results and relative experimental work of a companion study (Paper I). METHODS: Broad electron beam CE-to-dose conversion factors k C θ ± δ θ include CE generated at polar angles θ ± Î´Î¸ on beam axis in water. With modifications to the EGSnrc code SPRRZnrc, k C θ ± δ θ factors are calculated for a total of 20 electron beam qualities from four BEAMnrc models (Varian Clinac 2100C/D, Clinac 21EX, TrueBeam, and Elekta Precise). We examine beam quality, depth, and detection angle dependence for θ ± δ θ = 90 ∘ ± 90 ∘ (4π detection), 90 ∘ ± 5 ∘ , 45 ∘ ± 45 ∘ , and 90 ∘ ± 45 ∘ . As discussed in Paper I, 4π detection offers the strongest CE-dose correlation and θ = 90 ∘ with small δθ is most practical. The two additional configurations are considered as a compromise between these two extremes. We address beam quality specification and reference depth selection in terms of the electron beam quality specifier R 50 , obtained from the depth of 50% CE C 50 , and derive a best-case uncertainty budget for the CE-based dosimetry formalism proposed in Paper I at each detection configuration. RESULTS: The k C θ ± δ θ factor was demonstrated to capture variations in the beam spectrum, angle, photon contamination, and electron fluence below the CE threshold (∼260 keV in the visible) in accordance with theory. The root-mean-square deviation and maximum deviation of a second-order polynomial fit of simulated R 50 values in terms of C 50 were 0.05 and 0.11 mm at 4π and 0.20 and 0.33 mm at 90 ∘ ± 5 ∘ detection, respectively. The fit performance on experimental data in Paper I was in agreement with these values within experimental uncertainties (±1.5 mm, 95% CI). A two-term power function fit of k C θ ± δ θ in terms of R 50 at a reference depth d ref = a R 50 + b resulted in total d ref -dependent dose uncertainty contribution estimate of 0.8% and 1.1% and preliminary best-case estimate of the combined standard dose uncertainty of 1.1% and 1.3% at 4π and 90 ∘ ± 5 ∘ detection, respectively. The results and corresponding uncertainties with the two intermediate apertures were generally of the same order as the 4π case. In addition, a theoretically consistent downstream shift of the percent-depth CE (PDC) by the difference between R 50 and C 50 improved the depth dependence of the 4π conversion by an order of magnitude (±2.8%). Therefore, a large aperture centered on a θ value between 45 ∘ and 90 ∘ combined with a downstream PDC shift may be recommended for beam-axis CE-based electron beam dosimetry in water. CONCLUSIONS: By delivering R 50 -based CE-to-dose conversion data and demonstrating the potential for dosimetric uncertainty on the order of 1%, we bring CE-based electron beam dosimetry closer to clinical realization.

Scintillation Yield Estimates of Colloidal Cerium-Doped LaF3 Nanoparticles and Potential for "Deep PDT".

A hybrid of radiotherapy and photodynamic therapy (PDT) has been proposed in previously reported studies. This approach utilizes scintillating nanoparticles to transfer energy to attached photosensitizers, thus generating singlet oxygen for local killing of malignant cells. Its effectiveness strongly depends upon the scintillation yield of the nanoparticles. Using a liquid scintillator as a reference standard, we estimated the scintillation yield of Ce0.1La0.9F3/LaF3 core/shell nanoparticles at 28.9 mg/ml in water to be 350 photons/MeV under orthovoltage X-ray irradiation. The subsequent singlet oxygen production for a 60 Gy cumulative dose to cells was estimated to be four orders of magnitude lower than the "Niedre killing dose," used as a target value for effective cell killing. Without significant improvements in the radioluminescence properties of the nanoparticles, this approach to "deep PDT" is likely to be ineffective. Additional considerations and alternatives to singlet oxygen are discussed.

Dosimetric effects near implanted vascular access ports: an examination of external photon beam calculation.

Vascular access ports are used widely in the administering of drugs for radiation oncology patients. Their dosimetric effect on radiation therapy delivery in photon beams has not been rigorously established. In this work the effects on external beam fields when any of a variety of vascular access ports is included in the path of a high energy beam are studied. This medical physics study specifically identifies side-scatter and back-scatter consequences as well as attenuation effects. The study was divided into two parts: Firstly, a total of 18 ports underwent extended HU range CT scanning followed by 3-D computer treatment planning, where independent homogeneity and heterogeneity plans were created for photon beams of energy 6 MV and 18 MV using a Pencil Beam Convolution (PBC) algorithm. Dose points were analyzed at locations all around each device. A total of 1,440 points were reviewed in this section of the study. Secondly, a mock-up of the largest vascular access port was created in the treatment planning workspace for further investigation with alternative treatment planning algorithms. Plans were generated identically to the above and compared to the results of dose computation between the Pencil Beam Convolution algorithm, the Analytical Anisotropic Algorithm (AAA), and the EGSnrc Monte Carlo algorithm with user code DOSRZnrc (MC). A total of 300 points were reviewed in this part of the study. It was conclusive that ports with more bulky construction and those with partial metal composition create the largest changes. Similar effects are seen for similar port configurations. Considerable differences between the PBC and AAA in comparison to MC are noted and discussed. By thorough examination of planning system results, the presented vascular access ports may now be ranked according to the greatest amount of change exhibited within a treatment planning system. Effects of backscatter, lateral scatter and attenuation are up to 5.0%, 3.4% and 16.8% for 6 MV and 7.0%, 7.7% and 7.2% for 18 MV respectively.

Third-party brachytherapy source calibrations and physicist responsibilities: report of the AAPM Low Energy Brachytherapy Source Calibration Working Group.

The AAPM Low Energy Brachytherapy Source Calibration Working Group was formed to investigate and recommend quality control and quality assurance procedures for brachytherapy sources prior to clinical use. Compiling and clarifying recommendations established by previous AAPM Task Groups 40, 56, and 64 were among the working group's charges, which also included the role of third-party handlers to perform loading and assay of sources. This document presents the findings of the working group on the responsibilities of the institutional medical physicist and a clarification of the existing AAPM recommendations in the assay of brachytherapy sources. Responsibility for the performance and attestation of source assays rests with the institutional medical physicist, who must use calibration equipment appropriate for each source type used at the institution. Such equipment and calibration procedures shall ensure secondary traceability to a national standard. For each multi-source implant, 10% of the sources or ten sources, whichever is greater, are to be assayed. Procedures for presterilized source packaging are outlined. The mean source strength of the assayed sources must agree with the manufacturer's stated strength to within 3%, or action must be taken to resolve the difference. Third party assays do not absolve the institutional physicist from the responsibility to perform the institutional measurement and attest to the strength of the implanted sources. The AAPM leaves it to the discretion of the institutional medical physicist whether the manufacturer's or institutional physicist's measured value should be used in performing dosimetry calculations.

Monte Carlo feasibility study of orthogonal bremsstrahlung beams for improved radiation therapy imaging.

The basic characteristics of orthogonal bremsstrahlung beams are studied and the feasibility of improved contrast imaging with such a beam is evaluated. In the context of this work, orthogonal bremsstrahlung beams represent the component of the bremsstrahlung distribution perpendicular to the electron beam impinging on an accelerator target. The BEAMnrc Monte Carlo code was used to study target characteristics, energy spectra and relative fluences of orthogonal beams to optimize target design. The reliability of the simulations was verified by comparing our results with benchmark experiments. Using the results of the Monte Carlo optimization, the targets with various materials and a collimator were designed and built. The primary pencil electron beam from the research port of a Varian Clinac-18 accelerator striking on Al, Pb and C targets was used to create orthogonal beams. For these beams, diagnostic image contrast was tested by placing simple Lucite objects in the path of the beams and comparing image contrast obtained in the orthogonal direction to the one obtained in the forward direction. The simulations for various target materials and various primary electron energies showed that a width of 80% of the continuous-slowing-down approximation range (RCSDA) is sufficient to remove electron contamination in the orthogonal direction. The photon fluence of the orthogonal beam for high Z targets is larger compared to low Z targets, i.e. by a factor of 20 for W compared to Be. For a 6 MeV electron beam, the mean energy for low Z targets is calculated to be 320 keV for Al and 150 keV for Be, and for a high Z target like Pb to be 980 keV. For irradiation times of 1.2 s in an electron mode of the linac, the contrast of diagnostic images created with orthogonal beams from the Al target is superior to that in the forward direction. The image contrast and the beam profile of the bremsstrahlung beams were also studied. Both the Monte Carlo study and experiment showed an improvement of the contrast for lower Z target materials. This study confirms the feasibility, both in terms of intensity and image contrast, of orthogonal bremsstrahlung beams for radiation therapy imaging.

Radiation induced currents in parallel plate ionization chambers: measurement and Monte Carlo simulation for megavoltage photon and electron beams.

Polarity effects in ionization chambers are caused by a radiation induced current, also known as Compton current, which arises as a charge imbalance due to charge deposition in electrodes of ionization chambers. We used a phantom-embedded extrapolation chamber (PEEC) for measurements of Compton current in megavoltage photon and electron beams. Electron contamination of photon beams and photon contamination of electron beams have a negligible effect on the measured Compton current. To allow for a theoretical understanding of the Compton current produced in the PEEC effect we carried out Monte Carlo calculations with a modified user code, the COMPTON/ EGSnrc. The Monte Carlo calculated COMPTON currents agree well with measured data for both photon and electron beams; the calculated polarity correction factors, on the other hand, do not agree with measurement results. The conclusions reached for the PEEC can be extended to parallel-plate ionization chambers in general.

Validation of Monte Carlo calculated surface doses for megavoltage photon beams.

Recent work has shown that there is significant uncertainty in measuring build-up doses in mega-voltage photon beams especially at high energies. In this present investigation we used a phantom-embedded extrapolation chamber (PEEC) made of Solid Water to validate Monte Carlo (MC)-calculated doses in the dose build-up region for 6 and 18 MV x-ray beams. The study showed that the percentage depth ionizations (PDIs) obtained from measurements are higher than the percentage depth doses (PDDs) obtained with Monte Carlo techniques. To validate the MC-calculated PDDs, the design of the PEEC was incorporated into the simulations. While the MC-calculated and measured PDIs in the dose build-up region agree with one another for the 6 MV beam, a non-negligible difference is observed for the 18 MV x-ray beam. A number of experiments and theoretical studies of various possible effects that could be the source of this discrepancy were performed. The contribution of contaminating neutrons and protons to the build-up dose region in the 18 MV x-ray beam is negligible. Moreover, the MC calculations using the XCOM photon cross-section database and the NIST bremsstrahlung differential cross section do not explain the discrepancy between the MC calculations and measurement in the dose build-up region for the 18 MV. A simple incorporation of triplet production events into the MC dose calculation increases the calculated doses in the build-up region but does not fully account for the discrepancy between measurement and calculations for the 18 MV x-ray beam.

Physical aspects of dynamic stereotactic radiosurgery with very small photon beams (1.5 and 3 mm in diameter).

Stereotactic radiosurgery is often used for treating functional disorders. For some of these disorders, the size of the target can be on the order of a millimeter and the radiation dose required for treatment on the order of 80 Gy. The very small radiation field and high prescribed dose present a difficult challenge in beam calibration, dose distribution calculation, and dose delivery. In this work the dose distribution for dynamic stereotactic radiosurgery, carried out with 1.5 and 3 mm circular fields, was studied. A 10 MV beam from a Clinac-18 linac (Varian, Palo Alto, CA) was used as the radiation source. The BEAM/EGS4 Monte Carlo code was used to model the treatment head of the machine along with the small-field collimators. The models were validated with the EGSnrc code, first through a calculation of percent depth doses (PDD) and dose profiles in a water phantom for the two small stationary circular beams and then through a comparison of the calculated with measured PDD and profile data. The three-dimensional (3-D) dose distributions for the dynamic rotation with the two small radiosurgical fields were calculated in a spherical water phantom using a modified version of the fast XVMC Monte Carlo code and the validated models of the machine. The dose distributions in a horizontal plane at the isocenter of the linac were measured with low-speed radiographic film. The maximum sizes of the Monte Carlo-calculated 50% isodose surfaces in this horizontal plane were 2.3 mm for the 1.5 mm diameter beam and 3.8 mm for the 3 mm diameter beam. The maximum discrepancies between the 50% isodose surface on the film and the 50% Monte Carlo-calculated isodose surfaces were 0.3 mm for both the 1.5 and 3 mm beams. In addition, the displacement of the delivered dose distributions with respect to the laser-defined isocenter of the machine was studied. The results showed that dynamic radiosurgery with very small beams has a potential for clinical use.

Measurement of absorbed dose with a bone-equivalent extrapolation chamber.

A hybrid phantom-embedded extrapolation chamber (PEEC) made of Solid Water and bone-equivalent material was used for determining absorbed dose in a bone-equivalent phantom irradiated with clinical radiation beams (cobalt-60 gamma rays; 6 and 18 MV x rays; and 9 and 15 MeV electrons). The dose was determined with the Spencer-Attix cavity theory, using ionization gradient measurements and an indirect determination of the chamber air-mass through measurements of chamber capacitance. The collected charge was corrected for ionic recombination and diffusion in the chamber air volume following the standard two-voltage technique. Due to the hybrid chamber design, correction factors accounting for scatter deficit and electrode composition were determined and applied in the dose equation to obtain absorbed dose in bone for the equivalent homogeneous bone phantom. Correction factors for graphite electrodes were calculated with Monte Carlo techniques and the calculated results were verified through relative air cavity dose measurements for three different polarizing electrode materials: graphite, steel, and brass in conjunction with a graphite collecting electrode. Scatter deficit, due mainly to loss of lateral scatter in the hybrid chamber, reduces the dose to the air cavity in the hybrid PEEC in comparison with full bone PEEC by 0.7% to approximately 2% depending on beam quality and energy. In megavoltage photon and electron beams, graphite electrodes do not affect the dose measurement in the Solid Water PEEC but decrease the cavity dose by up to 5% in the bone-equivalent PEEC even for very thin graphite electrodes (<0.0025 cm). In conjunction with appropriate correction factors determined with Monte Carlo techniques, the uncalibrated hybrid PEEC can be used for measuring absorbed dose in bone material to within 2% for high-energy photon and electron beams.