RESUMO
5 patients with ichthyosis had a neurological accompaniment: epilepsy in 4, congenital palpebral ptosis, facial pain and neurosis in 1. In one patient epilepsy was combined with multiple malformations (normal dwarfism, prematurely old face, skeletal abnormalities) and oligophrenia. There was considerable variability genetically: 2 sporadic cases, 1 with X-linked transmission, 1 with autosomal dominant and 1 with apparent autosomal recessive heredity. In one case the co-existence of glucose-6-phosphate dehydrogenase deficiency provided proof of X-linked transmission. Further study of larger case-series is needed for a better definition of the nosographic and genetic aspects of non blastomatous neuroectodermatoses in which ichthyosis figures.
Assuntos
Epilepsia/complicações , Ictiose/complicações , Doenças do Sistema Nervoso/complicações , Adolescente , Adulto , Blefaroptose/congênito , Criança , Dor Facial/complicações , Feminino , Deficiência de Glucosefosfato Desidrogenase/complicações , Humanos , Ictiose/genética , Deficiência Intelectual/complicações , Masculino , Transtornos Neuróticos/complicações , Talassemia/complicaçõesAssuntos
Epilepsia Pós-Traumática/epidemiologia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Eletroencefalografia , Epilepsia Pós-Traumática/diagnóstico , Epilepsia Pós-Traumática/diagnóstico por imagem , Feminino , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios XRESUMO
33 drug abusers were examined and all of them were addicts to several drugs and always to heroin. Neurological complications occurred rather frequently. One patient had subarachnoid hemorrhage and angiography showed no arteriovenous malformations nor other pathology. Polyneuropathy has been found in one case. 7 patients (21,2%) developed psychotic episodes. Epileptic attacks were found in 5 cases (15,1%). Latency between the onset of drug-abusing and occurrence of the attacks was found to be at least 1 year in two cases and 3 years in the other three. 4 cases suffered from partial complex seizures with secondary generalization and one patient had generalized tonic-clonic attacks. Fits occurred rarely in all cases; one patient had two episodes of partial status. Further research is required because there are few clinical reports in comparison with the experimental ones.