Acute Lymphoblastic Leukemia Detection and Classification of Its Subtypes Using Pretrained Deep Convolutional Neural Networks.

Leukemia is a fatal disease of white blood cells which affects the blood and bone marrow in human body. We deployed deep convolutional neural network for automated detection of acute lymphoblastic leukemia and classification of its subtypes into 4 classes, that is, L1, L2, L3, and Normal which were mostly neglected in previous literature. In contrary to the training from scratch, we deployed pretrained AlexNet which was fine-tuned on our data set. Last layers of the pretrained network were replaced with new layers which can classify the input images into 4 classes. To reduce overtraining, data augmentation technique was used. We also compared the data sets with different color models to check the performance over different color images. For acute lymphoblastic leukemia detection, we achieved a sensitivity of 100%, specificity of 98.11%, and accuracy of 99.50%; and for acute lymphoblastic leukemia subtype classification the sensitivity was 96.74%, specificity was 99.03%, and accuracy was 96.06%. Unlike the standard methods, our proposed method was able to achieve high accuracy without any need of microscopic image segmentation.

Computer-Aided Diagnosis of Acute Lymphoblastic Leukaemia.

Leukaemia is a form of blood cancer which affects the white blood cells and damages the bone marrow. Usually complete blood count (CBC) and bone marrow aspiration are used to diagnose the acute lymphoblastic leukaemia. It can be a fatal disease if not diagnosed at the earlier stage. In practice, manual microscopic evaluation of stained sample slide is used for diagnosis of leukaemia. But manual diagnostic methods are time-consuming, less accurate, and prone to errors due to various human factors like stress, fatigue, and so forth. Therefore, different automated systems have been proposed to wrestle the glitches in the manual diagnostic methods. In recent past, some computer-aided leukaemia diagnosis methods are presented. These automated systems are fast, reliable, and accurate as compared to manual diagnosis methods. This paper presents review of computer-aided diagnosis systems regarding their methodologies that include enhancement, segmentation, feature extraction, classification, and accuracy.