RESUMO
The effect of nifedipine, a calcium antagonist on fasting blood glucose level, glucose tolerance, glucose-induced insulin and glucagon secretion was studied in healthy nondiabetic volunteers. Nifedipine 10mg twice daily for four weeks did not affect fasting blood glucose level, glucose tolerance, glucose-induced insulin and glucagon secretion.
Assuntos
Glicemia , Nifedipino/farmacologia , Adulto , Humanos , MasculinoRESUMO
The effects of the calcium antagonists verapamil and nifedipine on blood glucose levels, glucose tolerance, insulin secretion during glucose tolerance and hypoglycaemic effect of tolbutamide were studied in normal nondiabetic rabbits. Daily dosage of 40 mg/kg verapamil and 5 mg/kg nifedipine given orally up to 7 days did not affect blood glucose level, glucose tolerance, insulin secretion during glucose tolerance and hypoglycaemic activity of tolbutamide 250 mg/kg p.o.
Assuntos
Glicemia/metabolismo , Bloqueadores dos Canais de Cálcio/farmacologia , Animais , Teste de Tolerância a Glucose , Insulina/metabolismo , Secreção de Insulina , Masculino , Nifedipino/farmacologia , Coelhos , Tolbutamida/farmacologia , Verapamil/farmacologiaAssuntos
Cálcio/farmacologia , Contração Miocárdica/efeitos dos fármacos , Potássio/farmacologia , Ácido Valproico/farmacologia , Acetilcolina/farmacologia , Animais , Atropina/farmacologia , Interações Medicamentosas , Epinefrina/farmacologia , Histamina/farmacologia , Coelhos , Ranidae , Especificidade da EspécieAssuntos
Encéfalo/metabolismo , Peróxidos Lipídicos/antagonistas & inibidores , Riboflavina/farmacologia , Animais , Clofibrato/farmacologia , Feminino , Hipolipemiantes , Técnicas In Vitro , Peróxidos Lipídicos/metabolismo , Masculino , Niacinamida/farmacologia , Propilenoglicóis/farmacologia , RatosRESUMO
Six basic amides were screened for local anaesthetic activity and compared with procaine and lignocaine. Amongst the basic amides screened, piperidino-N-(alpha-4-ethoxy phenyl- beta-phenyl) ethyl and Diethylamino-N (alpha-4-ethoxy- beta-phenyl) ethyl acetamide were found to be more effective as compared to lignocaine. They were found to be non-irritant, and non-toxic even in high doses.
Assuntos
Acetamidas/farmacologia , Anestésicos Locais , Acetamidas/toxicidade , Animais , Cobaias , Dose Letal Mediana , Lidocaína/farmacologia , Procaína/farmacologia , CoelhosRESUMO
3-Substituted thieno [2, 3-d] pyrimidin-4(3H)-one-2-mercaptoacetic acids and their ethyl esters were synthesized from 2-mercaptothieno [2, 3-d] pyrimidin-4(3H]-ones, which were obtained by cyclization of thienylthioureas in acidic medium. Analgesic, anti-inflammatory, and anticonvulsant activities were found in some of these compounds. Significant antimicrobial activity was exhibited by thienylthioureas.
