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1.
J Coll Physicians Surg Pak ; 23(4): 242-6, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23552531

RESUMO

OBJECTIVE: To find any difference in the fasting lipid profile in patients with history of ischaemic heart disease (IHD) and established atherosclerotic plaques on angiography and in subjects with no known history of IHD. STUDY DESIGN: Observational, cross-sectional study. PLACE AND DURATION OF STUDY: Immunology Department of University of Health Sciences, Lahore, from January 2007 to January 2009. METHODOLOGY: In this study, 200 male subjects, between 40 and 60 years of age were recruited. Serum cholesterol and triglycerides were determined by enzymatic CHOD-PAP and GPO-PAP calorimetric method, HDL-C by accelerator selective detergent method and LDL-C by direct homogeneous enzymatic method. Serum ox-LDL contents were determined by using quantitative sandwich enzyme immuno-assay kits. RESULTS: The total serum cholesterol, triglyceride and LDL-C levels were within the normal range in control and patient groups whereas HDL-C levels were significantly higher in the control group compared to the patient group (p = 0.001). A significant difference (p = 0.001) for HDL-C levels was observed between smokers and non-smokers. Serum ox-LDL levels were higher in patient group as compared to the control group but the difference was not statistically significant. CONCLUSION: The significantly lower HDL levels in patient group with normal cholesterol, LDL and triglyceride levels may suggest low HDL-C has a greater role in IHD. Raising plasma HDL-cholesterol through weight loss, healthy diet, increased physical activity and by proper pharmacotherapy is, therefore, a legitimate therapeutic target for the optimal prevention of CHD in native population.


Assuntos
Lipídeos/sangue , Isquemia Miocárdica/diagnóstico , Placa Aterosclerótica/diagnóstico por imagem , Adulto , Angiografia , Estudos de Casos e Controles , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Estudos Transversais , Humanos , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/sangue , Placa Aterosclerótica/sangue , Fatores de Risco , Triglicerídeos/sangue
2.
Iran J Immunol ; 7(2): 109-16, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20574124

RESUMO

BACKGROUND: Atherosclerosis is an inflammatory and multifactorial disease, with a high prevalence rate in Pakistan. OBJECTIVE: To find a relation between serum IL-4 and IgE levels with oxidized LDL in atherosclerosis. METHODS: In this observational, cross sectional study 99 male patients, between forty and sixty years of age, with a history of ischemic heart disease (IHD) and established atherosclerotic plaques on angiography were recruited. The study was completed within three years (Jan 2007 to Jan 2009). One hundred and one age and gender matched healthy subjects with no known history of IHD were also recruited. All the study participants were non-diabetics. Serum IL-4, IgE and oxidized LDL (ox-LDL) levels were measured by quantitative ELISA technique. RESULTS: Serum IL-4 levels were generally undetectable or very low, but were higher in the patient group compared to the control subjects. Similarly, oxidized LDL and serum IgE levels were also increased in the patient group compared to the control, but the differences were not statistically significant. CONCLUSION: Our study could not detect any relationship between IL-4 and IgE levels with LDL oxidation in atherosclerosis.


Assuntos
Aterosclerose/diagnóstico , Interleucina-4/sangue , Isquemia Miocárdica/diagnóstico , Adulto , Aterosclerose/sangue , Aterosclerose/complicações , Aterosclerose/fisiopatologia , Angiografia Coronária , Estudos Transversais , Humanos , Imunoglobulina E/sangue , Lipoproteínas LDL/sangue , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/sangue , Isquemia Miocárdica/complicações , Isquemia Miocárdica/fisiopatologia , Paquistão
3.
J Ayub Med Coll Abbottabad ; 21(3): 59-62, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20929015

RESUMO

OBJECTIVES: To find any association of white blood cells, haemoglobin and ESR with ischemic heart disease in high risk native population. METHODOLOGY: The study included 93 male patients with Ischemic heart disease, between 40 and 60 years of age; 96 age and gender matched subjects. All study participants were non-diabetics. Complete blood cells count, haemoglobin and ESR levels were compared between the patient and control groups. RESULTS: Total leukocyte counts along with neutrophils were significantly higher in the test group compared to the control population (p < 0.001) and lymphocytes were significantly lower (p < 0.001) in the patient group as compared to the control group. Haemoglobin levels were significantly lower (p < 0.001) and ESR was higher (p = 0.030) in the patient group as compared to the control group. CONCLUSION: Although, our findings of the study variables extend previous reports, the prevalence and prognostic importance of theses variables in IHD should be assessed in future experimental studies. These parameters could be important in public health because they are routinely measured by clinicians and may be helpful to predict the risk of future and secondary ischemic events in a high risk population.


Assuntos
Hemoglobinas/análise , Contagem de Leucócitos , Isquemia Miocárdica/sangue , Adulto , Sedimentação Sanguínea , Estudos de Casos e Controles , Distribuição de Qui-Quadrado , Comorbidade , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estatísticas não Paramétricas
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