[Disturbance of equilibrium between blood levels of antioxidant and prooxidant metalloproteins in pain stress in children]. / Narushenie ravnovesiia mezhdu urovnem antioksidantnykh i prooksidantnykh metalloproteinov krovi pri bolevom stresse u detei.

Molecular mechanisms of the trauma stress of different origins in children to some extent is related to the quantitative changes of blood superoxide dismutase, catalase, ceruloplasmin, transferrin, cytochromes b5, b558III, b558IV and suprol. Non adequate changes of antioxidant (superoxide dismutase, catalase, ceruloplasmin, transferrin) and newly discovered prooxidant (cytochromes b5, b558III, b558IV, suprol) metalloproteins, as well as serum and erythrocyte cytochrome b5 depend on characteristic and duration of trauma stress caused by extremity fractures in children. This is due to the different mechanisms of adaptation to trauma stress.

[Level of blood metalloproteins during fluothane anesthesia in experimental animals]. / Uroven' metalloproteinov krovi pri anestezii ftorotanom v éksperimente.

Changes in the concentrations of antioxidant (Cu, Zn superoxide dismutase catalase, ceruloplasmin, and transferrin) and recently discovered pro-oxidant (cytochrome B-558 I-IV and suprol, a superoxide producing lipoprotein) metalloproteins and cytochrome B-5 were assessed in the blood of anesthesized and control rats. The concentrations of antioxidant and pro-oxidant metalloproteins varied. They were not changed during anesthesia, except suprol. As for the qualitative changes, phospholipid composition was altered, superoxide production decreased, and lipid peroxidation of suprol increased during anesthesia. The authors propose using antioxidant metalloproteins for decrease of the undesirable consequences of halothane anesthesia in experimental medicine.