Effects of size at birth on health, growth and developmental outcomes in children up to age 18: an umbrella review.

BACKGROUND: Size at birth, an indicator of intrauterine growth, has been studied extensively in relation to subsequent health, growth and developmental outcomes. Our umbrella review synthesises evidence from systematic reviews and meta-analyses on the effects of size at birth on subsequent health, growth and development in children and adolescents up to age 18, and identifies gaps. METHODS: We searched five databases from inception to mid-July 2021 to identify eligible systematic reviews and meta-analyses. For each meta-analysis, we extracted data on the exposures and outcomes measured and the strength of the association. FINDINGS: We screened 16 641 articles and identified 302 systematic reviews. The literature operationalised size at birth (birth weight and/or gestation) in 12 ways. There were 1041 meta-analyses of associations between size at birth and 67 outcomes. Thirteen outcomes had no meta-analysis.Small size at birth was examined for 50 outcomes and was associated with over half of these (32 of 50); continuous/post-term/large size at birth was examined for 35 outcomes and was consistently associated with 11 of the 35 outcomes. Seventy-three meta-analyses (in 11 reviews) compared risks by size for gestational age (GA), stratified by preterm and term. Prematurity mechanisms were the key aetiologies linked to mortality and cognitive development, while intrauterine growth restriction (IUGR), manifesting as small for GA, was primarily linked to underweight and stunting. INTERPRETATION: Future reviews should use methodologically sound comparators to further understand aetiological mechanisms linking IUGR and prematurity to subsequent outcomes. Future research should focus on understudied exposures (large size at birth and size at birth stratified by gestation), gaps in outcomes (specifically those without reviews or meta-analysis and stratified by age group of children) and neglected populations. PROSPERO REGISTRATION NUMBER: CRD42021268843.

Health system considerations related to voluntary and forced displacement in the Eastern Mediterranean Region: a critical analysis of the available literature.

BACKGROUND: The WHO Region for the Eastern Mediterranean has had a history of complex migration patterns, with high levels of migration to, from and within the Region, overlaid by massive recent forced displacement. Relatively little is known about the health system response to this large-scale mobility. AIMS: To review the literature on the Region critically, identify gaps and suggest areas needing research and policy attention. METHOD: A search of the published literature using MEDLINE and POPLINE was conducted on health and migration focusing on the WHO health system building blocks with no date or language limitations. RESULTS: Out of 4679 retrieved articles published between 1964 and January 2019, 140 met our inclusion criteria; 45 additional articles were included in a December 2020 update. Most publications focused on refugees and on the delivery of services. CONCLUSIONS: Few studies explored the responsiveness of health system to refugees and migrants compared with those for host communities, or assessed the quality of services or refugees'/migrants' perceptions of available health services. Few suggested new approaches to financing health care access for these populations or new governance arrangements.

Indirect impact of violent events on emergency department utilization and disease patterns.

BACKGROUND: The health effects of war and armed conflict on casualties and mental health of those directly exposed has been well described, but few studies have explored the indirect health effects of violent events. This paper assesses the indirect health impact of several violent events that took place in Beirut in 2013-2014 on ED visit utilization and disease patterns. METHODS: As tracked by media reports, there were 9 violent events in Beirut during 2013-2014. We compared visits to the Emergency Department of a major medical center during weeks when violent events happened and weeks without such events (the preceding week and the same week in preceding years). After re-coding de-identified data from the medical records of 23,067 patients, we assessed differences in the volume of visits, severity index, and discharge diagnoses. Individual control charts were used to analyze ED visit trends post-event. RESULTS: Comparisons of weeks with violent events and weeks without such events indicate that the socio-demographic characteristics of patients who visited the Emergency Department were similar. Patients seen during violent weeks were significantly more likely to be admitted to the hospital, and less likely to present with low acuity complaints, indicating greater complexity of their conditions. The discharge diagnoses that were significantly higher during violent event weeks included anxiety disorders, sprains, and gastritis. Daily ED visits dropped post events by 14.111%, p < 0.0001. CONCLUSIONS: The results indicate that violent events such as bombs, explosions, and terrorist attacks reverberate through the population, impact patterns of ED utilization immediately post-event and are associated with adverse health outcomes, even among those who are not directly affected by the events.

Public Knowledge of, Perceptions About and Attitudes Towards Dementia: A Cross-Sectional Survey Among Lebanese Primary Health Care Attenders.

Dementia is a leading cause of dependency and disability among older adults. Minimal knowledge, poor attitudes and negative perceptions are barriers of dementia early screening, diagnosis and treatment. This is the first study that assesses knowledge, attitudes and perceptions of dementia among a Middle Eastern population. Two hundred and fifty-four Lebanese adults not having dementia attending primary healthcare centers in the capital of Lebanon were interviewed using an Arabic version of the 2010 Northern Ireland Life and Times survey. The highest proportion of the participants (61%) had low knowledge score. Low knowledge was associated with older age and lower education. The majority had a negative perception towards people living with dementia and these perceptions were significantly different by gender, education and exposure. Participants perceived people with dementia as helpless and dependent. Public interventions should address stigma and increase knowledge while understanding the socio-cultural beliefs associated with dementia. The study calls for policy developments and conducting a qualitative study.

Does intervention improve the outcomes of patients after total knee replacement surgery?

OBJECTIVE: To assess the effect of a one to one intervention by a nurse on the outcomes of patients undergoing Total Knee Replacement (TNR) surgery. METHODS: A quasi-experimental design was used with 60 participants, half of which received a one to one intervention including education and exercise training by a nurse prior to surgery. Follow up was at two and four weeks post-surgery to assess pain, knee function using the Hospital for Special Surgery (HSS) Knee Rating Sheet and activities of daily living measured on the Lower Extremity Functional Scale (LEFS). ANOVA tests were used to compare significant differences between groups. RESULTS: The intervention group had less pain at two and four weeks, p = 0.00, and better knee function at four weeks, p = 0.026. Activities of daily living were better for the intervention group at both two and four weeks, p = 0.002 and 0.048. CONCLUSION: The one to one intervention provided by a nurse before TKR surgery was instrumental in decreasing pain, improving knee function and enhancing activities of daily living.

Physical inactivity, gender and culture in Arab countries: a systematic assessment of the literature.

BACKGROUND: Physical inactivity is associated with excess weight and adverse health outcomes. We synthesize the evidence on physical inactivity and its social determinants in Arab countries, with special attention to gender and cultural context. METHODS: We searched MEDLINE, Popline, and SSCI for articles published between 2000 and 2016, assessing the prevalence of physical inactivity and its social determinants. We also included national survey reports on physical activity, and searched for analyses of the social context of physical activity. RESULTS: We found 172 articles meeting inclusion criteria. Standardized data are available from surveys by the World Health Organization for almost all countries, but journal articles show great variability in definitions, measurements and methodology. Prevalence of inactivity among adults and children/adolescents is high across countries, and is higher among women. Some determinants of physical inactivity in the region (age, gender, low education) are shared with other regions, but specific aspects of the cultural context of the region seem particularly discouraging of physical activity. We draw on social science studies to gain insights into why this is so. CONCLUSIONS: Physical inactivity among Arab adults and children/adolescents is high. Studies using harmonized approaches, rigorous analytic techniques and a deeper examination of context are needed to design appropriate interventions.