[Comparison of morphological and biochemical indicators of prostatic growth and function in castrated rats receiving separately and simultaneously 5 alpha-dihydrotestosterone and 5 alpha-androstane-3 beta, 17 beta-diol]. / Sopostavlenie morfologicheskikh i nekotorykh biokhimicheskikh pokazatelei rosta i funktsii predstatel'noi zhelezy kastrirovannykh krys, poluchayshikh razdel'no i odnovremenno 5 alpha-digidrotestosteron i 5 alpha-androstan-3 beta, 17 beta-diol.

Experiments in vito showed that indicators of prostatic growth (organ mass, protein content, DNA) and function (acid phosphatase activity) of castrated rats regenerated under the influence of 5 alpha-dihydrotestosterone. The morphological structure of this organ showed a pronounced activation of the glandular epithelium proliferation by this metabolite without a significant effect on the connective tissue. The other testosterone metabolite 5 alpha-androstan-3 beta, 17 beta-diol did not influence biochemical indicators but according to the morphological data it stimulated the secretory activity of the glandular epithelium and connective tissue formation. As a result of a combined effect of the metabolites the influence of 5 alpha-dihydrotestosterone on the proliferative processes in the prostate was limited, and the response of the connective tissue to 5 alpha-androstan-3 beta, 17 beta-diol preserved. The results obtained were not in accord with a hypothesis that 5 alpha-dihydrotestosterone is the only physiologically active testosterone metabolite in the rat pancreas, and confirmed the idea of androgen functional interrelationship.

[The effect of testosterone propionate, 5 alpha-dihydrotestosterone and 5 alpha-androstan-3 beta, 17 beta-diol on acid phosphatase activity in the prostate of castrated rats]. / Deistvie propionata testosterona, 5 alpha-digidrotestosterona i 5 alpha-androstan-3 beta, 17 beta-diola na aktivnost' kisloi fosfatazy predstatel'noi zhelezy kastrirovannykh krys.

The acid phosphatase is studied in the prostate gland of rats. It is shown that 10 days after gonadectomy the activity of acid phosphatase lowered considerably. Administration of testosterone propionate or 5 alpha-dihydrotestosterone to castrated animals restored the enzyme activity whereas 5 alpha-androstan-3 beta,17-diol was not effective. Administration of testosterone propionate with one of its metabolites increased the activity of acid phosphatase in the prostate gland, however to a less extent than with the use of the hormone itself. The lowest activity is detected with the simultaneous application of three androgens.

[Various characteristics of the synthesis of nucleic acids and proteins in the prostate of castrated rabbits after separate and successive administration of testosterone and 5 alpha-dihydrotestosterone]. / Nekotorye osobennosti sinteza nukleinovykh kislot i belka v predstatel'noi zheleze kastrirovannykh krolikov pri razdel'nom i posledovatel'nom vvedenii testosterona 5 alpha-digidrotestosterona.

The results are presented of studying nucleic acid and protein synthesis in the rabbit prostate. It was shown that incorporation of radioactive precursors into the prostate DNA, RNA and proteins is diminished two months after gonadectomy of the animals. Testosterone and its metabolite 5 alpha-dihydrotestosterone markedly intensify RNA and protein synthesis in the prostate of castrated rabbits, whereas 5 alpha-dihydrotestosterone only exerts a stimulating effect upon DNA synthesis. Preliminary testosterone propionate injections to gonadectomized rabbits delay DNA synthesis, induced by 5 alpha-dihydrotestosterone, and decrease the marker incorporation into RNA and protein, comparatively to the effect of each separate androgen.

[Effect of 5alpha-androstan-3beta, 17beta-diol on serum lipids and lipoproteins and the development of experimental atherosclerosis]. / Vliianie 5alpha-androstan-3beta, 17beta-diola na lipidy i lipoproteidy syvorotki krovi i na razvitie éksperimental'nogo ateroskleroza.

The author studied the influence of testosterone metabolite--5alpha-androstan-3beta,17beta-diol--on the development of hyperlipidemia and atherosclerosis in chinchilla rabbits given cholesterol-free semisynthetic atherogenic diet. The metabolite under study inhibited the development of hypercholesterolemia and hyperbetalipoproteinemia and decreased blood phospholipid content in the blood serum of experimental animals below the initial level. Lipid content in the sum total fraction of pre-beta and beta-lipoproteins decreased under the effect of the mentioned metabolite; there was also a fall in the amount of lipoproteins of low density and their greater saturation with cholesterol. Development of experimental atherosclerosis was intensified.

[Effect of ethyl ether of p-chlorphenoxyisobutyric acid on the glucocorticoid function of the adrenal cortex of guinea pigs]. / Vliianie etilovogo efira p-khlorfenoksiizomaslianoi kisloty na gliukokortikoidnuiu funktsiiu kory nadpochechnikov morskikh svinok.

In administration to quinea pigs of ethyl-p-chlorophenoxyisobutyrate daily in a dose of 0.2 g/kg per os for 15-26 days decreased the 17-OHCS concentration in the peripheral blood plasma. A fall of the urinary excretion of individual 17-OHCS occurred chiefly at the expense of free unchanged cortisol, tetrahydrocortisol and tetrahydro-11-desoxycortisol. The zona fasciculate displays the abundance of the sudanophilic material. A test with ACTH demonstrated that the present functional reserves of the adrenal cortex failed to change under the effect of the preparation. The content of NEFA decreased in the blood serum; as to cholesterol level - it reamined unchanged. Possible mechanisms of the action of the preparation and prospects of its use for the treatment of hypercorticism are discussed.