RESUMO
Hormono-metabolic status was assayed before and after month 6, 12, 24, 36, 48, 54 and 60 of therapy in 72 patients with receptor-positive tumors of the breast who completed 5 years of adjuvant tamoxifen (20 mg/24 hrs) or letrozole (2.5 mg/24 hrs). Eleven patients were not followed up, 11 relapsed and had metastases while 50 completed therapy. Significant fall in body mass (Ketle's index), in C-peptide concentration after an insignificant rise and C-peptide/insulin ratio 129 min after glucose loading, low basal blood level of estradiol as well as stable estradiolemia throughout treatment were characteristic of cases of pre-treatment recurrence and metastastic spread. Insulin resistance status, basal serum-estradiol level and fasting its course of development during hormonotherapy should be the subject of further research in criteria for adjuvant hormonotherapy efficacy.
Assuntos
Antineoplásicos Hormonais/administração & dosagem , Biomarcadores Tumorais/sangue , Neoplasias da Mama/sangue , Neoplasias da Mama/tratamento farmacológico , Estradiol/sangue , Receptores de Estrogênio/sangue , Idoso , Peptídeo C/sangue , Quimioterapia Adjuvante , Feminino , Humanos , Insulina/sangue , Resistência à Insulina , Letrozol , Pessoa de Meia-Idade , Nitrilas/administração & dosagem , Receptores de Progesterona/sangue , Tamoxifeno/administração & dosagem , Fatores de Tempo , Triazóis/administração & dosagemRESUMO
Acute intestinal infections were clinically and epidemiologically studied in children residing in the towns with different quantitative and qualitative composition of ambient air pollutants and in the districts of a town, which differ in the level of technogenic ambient air pollution. Six hundred and eighty patients with different types of shigellosis and 421 patients with salmonellosis admitted to the infection hospitals of the towns of Angarsk (an intensively polluted locality) and Irkutsk (a better ecological area) were examined in 1995 to 2000. The technogenic ambient air pollution was found to exert a noticeable impact on the incidence with S. sonnei dysentery. In poor environmental areas, all the infections under study are characterized by a great burden, duration, more severe clinical symptoms, and poor laboratory changes in the presence of a decreased responsiveness.
