RESUMO
We report progressive necrotizing fungal cellulitis and myositis in the leg of a patient with glioblastoma multiforme treated with temozolomide and corticosteroids. While the morphologic appearance of the isolate and its ability to grow at temperatures greater than 32°C were suggestive of Mycoleptodiscus indicus, some of the conidia were atypical for this species in that they had single septa and occasional lateral appendages. Furthermore, the isolate was different from M. indicus based on the sequencing analysis of two rDNA regions. This is the first case of Mycoleptodiscus invasive fungal disease in which the causative agent could not be resolved at the species level because of inconsistencies between morphological and molecular data.
Assuntos
Ascomicetos/isolamento & purificação , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/microbiologia , Micoses/diagnóstico , Micoses/microbiologia , Miosite/diagnóstico , Miosite/microbiologia , Corticosteroides/administração & dosagem , Adulto , Anti-Inflamatórios/administração & dosagem , Antineoplásicos Alquilantes/administração & dosagem , Celulite (Flegmão)/complicações , Celulite (Flegmão)/patologia , Análise por Conglomerados , DNA Fúngico/química , DNA Fúngico/genética , DNA Ribossômico/química , DNA Ribossômico/genética , DNA Espaçador Ribossômico/química , DNA Espaçador Ribossômico/genética , Dacarbazina/administração & dosagem , Dacarbazina/análogos & derivados , Glioblastoma/complicações , Glioblastoma/tratamento farmacológico , Humanos , Perna (Membro)/patologia , Masculino , Dados de Sequência Molecular , Micoses/complicações , Micoses/patologia , Miosite/complicações , Miosite/patologia , Filogenia , Análise de Sequência de DNA , TemozolomidaRESUMO
Some interesting growth characteristics of Mycoleptodiscus terrestris were discovered while evaluating the fungus as a potential bioherbicide for management of the submersed macrophyte, Hydrilla verticillata. Microsclerotia were produced readily in a liquid culture medium containing a basal salts solution supplemented with corn steep liquor powder and glucose. Dried microsclerotia were capable of germinating hyphally within 24 h and sporogenically within 72 h. Initiation of spore production was not dependent on the presence of host plant material or light.
