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1.
Toxicol Lett ; 63(1): 1-5, 1992 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-1412519

RESUMO

A differentiated approach to the choice of criterion of reliability in toxicological studies is recommended. This approach is based on quantitative assessment of variability of biological parameters using the variation coefficient. All biological parameters are classified into rigid, flexible and high-flexible ones. The establishment of the biological significance of various parameters and assessment of the degree of their deviation allows the detection of prepathological changes in the body state, this being of importance for a more accurate LOAEL and NOAEL determination.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Animais , Humanos , Modelos Biológicos , Modelos Estatísticos , Eficiência Biológica Relativa
3.
Gig Sanit ; (2): 41-3, 1991 Feb.
Artigo em Russo | MEDLINE | ID: mdl-2055510

RESUMO

Results of hygienic study of baby's baths made of polystyrene are presented. Migration of components of the material into the water is studied, as well as skin-resorptive and sensitizing effect of polystyrene extracts on the organism of laboratory animals. The methodological procedure of hygienic investigation of plastic baby's baths is presented.


Assuntos
Banhos , Dermatite de Contato/etiologia , Poliestirenos/efeitos adversos , Alérgenos , Animais , Estudos de Avaliação como Assunto , Cobaias , Humanos , Lactente , Recém-Nascido
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