1.
ACS Catal
; 13(11): 7661-7668, 2023 Jun 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37288090
RESUMO
The alkynylation of 4-siloxyquinolinium triflates has been achieved under the influence of copper bis(oxazoline) catalysis. The identification of the optimal bis(oxazoline) ligand was informed through a computational approach that enabled the dihydroquinoline products to be produced with up to 96% enantiomeric excess. The conversions of the dihydroquinoline products to biologically relevant and diverse targets are reported.