RESUMO
Thirty patients with cerebral arachnoiditis and 26 with neurasthenia were found to have differences in the content of serotonin, 5-hydroxyindoleacetic++ acid and melatonin in the cerebrospinal fluid, which depended in arachnoiditis on the degree of intracranial pressure elevation. The data on serotonin metabolism can be used in objective evaluation of the organic background in neurotic patients and serve for estimating the intensity of hypertension in patients with cerebral arachnoiditis.
Assuntos
Aracnoidite/líquido cefalorraquidiano , Hidrocefalia/etiologia , Ácido Hidroxi-Indolacético/líquido cefalorraquidiano , Melatonina/líquido cefalorraquidiano , Neurastenia/líquido cefalorraquidiano , Pseudotumor Cerebral/etiologia , Serotonina/líquido cefalorraquidiano , Adulto , Aracnoidite/complicações , Feminino , Humanos , Hidrocefalia/diagnóstico , Pressão Intracraniana/fisiologia , Masculino , Pessoa de Meia-Idade , Neurastenia/complicações , Pseudotumor Cerebral/diagnósticoRESUMO
Concentrations of serotonin, 5-hydroxyindoleacetic acid, melatonin and parameters of the kinin system in the cerebrospinal fluid were monitored in 109 cases of brain tumor. All the levels were increased prior to surgery but returned to normal postoperatively unless disease followed an unfavorable course. It was suggested that the above-mentioned physiologically active substances play a certain role in compensatory mechanisms assuring recovery of CNS function.
Assuntos
Neoplasias Encefálicas/líquido cefalorraquidiano , Cininas/líquido cefalorraquidiano , Serotonina/líquido cefalorraquidiano , Adulto , Idoso , Neoplasias Encefálicas/cirurgia , Feminino , Fluorometria , Humanos , Ácido Hidroxi-Indolacético/líquido cefalorraquidiano , Masculino , Melatonina/líquido cefalorraquidiano , Pessoa de Meia-Idade , Prognóstico , EspectrofotometriaRESUMO
Study of 36 cases of ischemic myelopathy following a pseudotumorous course and 30 cases of spinal cord tumors revealed similarity and differences in the clinical manifestations which should be taken into account in differential diagnosis. Authentic differences in the content of serotonin and its metabolites in the cerebrospinal fluid and blood of this group of patients are pointed out.
Assuntos
Isquemia/diagnóstico , Doenças da Medula Espinal/diagnóstico , Neoplasias da Medula Espinal/diagnóstico , Medula Espinal/irrigação sanguínea , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Biomarcadores/líquido cefalorraquidiano , Plaquetas/química , Diagnóstico Diferencial , Feminino , Humanos , Ácido Hidroxi-Indolacético/líquido cefalorraquidiano , Isquemia/sangue , Isquemia/líquido cefalorraquidiano , Masculino , Melatonina/líquido cefalorraquidiano , Pessoa de Meia-Idade , Serotonina/sangue , Serotonina/líquido cefalorraquidiano , Doenças da Medula Espinal/sangue , Doenças da Medula Espinal/líquido cefalorraquidiano , Neoplasias da Medula Espinal/sangue , Neoplasias da Medula Espinal/líquido cefalorraquidianoRESUMO
Electromyography, electroneuromyography and monosynaptic N-reflex studies were performed in 61 patients with ischemic myelopathy. These data can be used to specify localization and the extent of the process. Its differentiation with several diseases providing a phenocopy of spinal disorders (tumors, lateral amyotrophic sclerosis syringomyelia, funicular myelosis) is discussed. The results of the study are important for evaluation of the extent of motor disorders compensation states in disabled functions, and hence, the patients' working capabilities.
Assuntos
Isquemia/fisiopatologia , Músculos/fisiopatologia , Doenças da Medula Espinal/fisiopatologia , Medula Espinal/irrigação sanguínea , Adulto , Idoso , Braço , Eletromiografia , Feminino , Humanos , Isquemia/etiologia , Perna (Membro) , Masculino , Pessoa de Meia-Idade , Doenças da Medula Espinal/complicaçõesRESUMO
Twenty-six patients with extra- and intramedullary tumors of the spinal cord had a considerably increased content of serotonin, 5-hydroxyindoleacetic acid, and melatonin in the cerebrospinal fluid (highest in patients with total blockade of the subarachnoid space) as well as of serotonin in blood platelets. The results of tests for serotonin metabolism can be used as a diagnostic test in the early stages of the tumor growth and are an additional factor in determining the indications for contrast examination of patients with a suspected spinal tumor.