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1.
Sci Rep ; 14(1): 11967, 2024 05 25.
Artigo em Inglês | MEDLINE | ID: mdl-38796540

RESUMO

Anaerobic co-digestion is an effective method for addressing the issue of a single substrate not being able to achieve optimal conditions for anaerobic digestion. By adjusting the mixture ratio of sewage sludge and food waste to achieve the optimal carbon to nitrogen ratio, the effectiveness of thermophilic-mesophilic temperature phase anaerobic co-digestion (TPAcD) was evaluated in comparison to single phase mesophilic anaerobic co-digestion (MAcD) and thermophilic anaerobic co-digestion (TAcD). The results indicated that TPAcD increased methane yield by 50.3% and 32.7% compared to MAcD and TAcD, respectively. The variation in VFA, pH, and ammonia nitrogen levels demonstrated that TPAcD combines the advantages of both MAcD and TAcD, with a higher hydrolysis rate in the early stage under thermophilic conditions (55 °C) and a suitable environment in the later stage under mesophilic conditions (35 °C). The kinetic parameters of anaerobic co-digestions also demonstrated that TPAcD performs better. Therefore, further research on TPAcD of sewage sludge and food waste is warranted due to its significant improvements in methane production rate, total methane yield, and system stability. Additionally, TPAcD contributes to reducing carbon emissions and supports the realization of "carbon neutrality".


Assuntos
Metano , Esgotos , Temperatura , Anaerobiose , Metano/metabolismo , Reatores Biológicos , Alimentos , Nitrogênio/metabolismo , Concentração de Íons de Hidrogênio , Cinética , Carbono/metabolismo , Perda e Desperdício de Alimentos
2.
Phys Rev Lett ; 123(5): 051602, 2019 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-31491301

RESUMO

We revisit the problem of boundary excitations at a topological boundary or junction defects between topological boundaries in nonchiral bosonic topological orders in 2+1 dimensions. Based on physical considerations, we derive a formula that relates the fusion rules of the boundary excitations and the "half-linking" number between condensed anyons and confined boundary excitations. This formula is a direct analogue of the Verlinde formula. We also demonstrate how these half-linking numbers can be computed in explicit Abelian and non-Abelian examples. As a fundamental property of topological orders and their allowed boundaries, this should also find applications in the search for suitable platforms realizing quantum computing devices.

3.
J Gerontol B Psychol Sci Soc Sci ; 74(5): 842-852, 2019 06 14.
Artigo em Inglês | MEDLINE | ID: mdl-29029215

RESUMO

OBJECTIVE: Research investigating long-term effects of childhood sexual abuse (CSA) on mental health for men is vastly underdeveloped. This study strengthened the knowledge base by examining: (a) long-term trajectories of depressive symptoms for men with and without a history of CSA, and (b) moderating effects of social support over time. METHOD: We analyzed multiple waves of data from the Wisconsin Longitudinal Study. The sample (N = 2,451) consisted of men with histories of CSA and a stratified, randomly sampled comparison group. Growth curve modeling was employed for analyses. RESULTS: After controlling for demographic, parental, and health factors, men with CSA histories had greater depressive symptoms than those with no history of CSA. For both groups, depressive symptoms decreased over time; slope patterns did not differ. We found a significant moderating effect of social support on the relationship between CSA and depressive symptoms. DISCUSSION: This innovative, population-based, longitudinal study demonstrated that CSA can undermine mental health for men across the life span and into old age. Social support appears to mitigate these deleterious effects. In early, middle, and late adulthood, practitioners should assess for CSA and strengthen support resources for male survivors.


Assuntos
Abuso Sexual na Infância/psicologia , Depressão/etiologia , Fatores Etários , Idoso , Criança , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Apoio Social , Fatores de Tempo
4.
Oncol Lett ; 14(4): 4800-4804, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29085482

RESUMO

Correlation between the expression of STK33 and the pathology of lung cancer was investigated, to explore its effects on prognosis. Hundred and two lung cancer patients diagnosed by pathological examinations were randomly selected in Shanghai Jiao Tong University Affiliated Sixth People's Hospital from February, 2012 to February, 2017 to serve as observation group, and the tumor tissues were collected. At the same time, 19 patients with lung benign lesions were selected and lung tissues were also collected to serve as control group. RT-qPCR was used to detect the expression of STK33 mRNA in tissues. Expression levels of STK33 protein were detected and compared by SP immunohistochemistry staining and western blot analysis. Statistical analysis was performed to analyze the correlation between STK33 expression and the pathology and prognosis of lung cancer. Results of PCR showed that expression level of STK33 gene in control group was significantly lower than that in observation group (p<0.05). The expression level of STK33 mRNA in lung adenocarcinoma and squamous cell carcinoma was lower than that in lung small cell carcinoma and large cell carcinoma (p<0.05). Western blot analysis showed that the expression level of STK33 protein in lung small cell carcinoma and large cell carcinoma was significantly higher than that in lung adenocarcinoma and squamous cell carcinoma (p<0.05). Immunohistochemistry staining showed that the positive rate of STK33 in lung large cell carcinoma (100%) and small cell carcinoma (100%) was significantly higher than that in lung adenocarcinoma (88.1%) and squamous cell carcinoma (86.2%) (p<0.05). The 5-year survival rate analysis showed that the recurrence-free survival rate and overall survival rate of STK33 gene high expression level group were significantly lower than those of low expression level group (p<0.05). The differential expression level of STK33 is related to the pathology and prognosis of lung cancer, which is of great value in clinical diagnosis and prognosis evaluation.

5.
Artigo em Inglês | MEDLINE | ID: mdl-28405161

RESUMO

Airway mucus hypersecretion is a frequent symptom associated with acute and chronic airway disease. Inhibition of mucus production or promotion of mucolysis not only relieved symptoms but also improved disease outcomes. There are numerous available mucoactive medicines for prescription, and how to select them properly for different diseases is important for clinical practice. So far, there is no one consensus or guideline reported. A group of Chinese pulmonary physicians worked together to complete this consensus based on literature review, summarized mechanism and usage of each classical mucoactive medicine. In general, antioxidant mucoactive medicines play an important role in chronic airway disease, including but not limited to airway mucus clearance, reduced acute exacerbation and improved pulmonary function.


Assuntos
Antioxidantes/uso terapêutico , Expectorantes/uso terapêutico , Pulmão/efeitos dos fármacos , Depuração Mucociliar/efeitos dos fármacos , Muco/metabolismo , Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico , Pneumologistas , Antioxidantes/efeitos adversos , China , Consenso , Progressão da Doença , Expectorantes/efeitos adversos , Humanos , Pulmão/metabolismo , Pulmão/fisiopatologia , Doença Pulmonar Obstrutiva Crônica/diagnóstico , Doença Pulmonar Obstrutiva Crônica/fisiopatologia , Qualidade de Vida , Recuperação de Função Fisiológica , Resultado do Tratamento
6.
Kaohsiung J Med Sci ; 33(3): 124-129, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28254114

RESUMO

In this study, we aimed to explore the association of genetic polymorphism in matrix metalloproteinase-9 (MMP-9) and transforming growth factor-ß1 (TGF-ß1) and the susceptibility to combined pulmonary fibrosis and emphysema (CPFE). We examined the polymorphisms of the MMP-9 C-1562T and TGF-ß1 T869C in 38 CPFE patients, 50 pulmonary emphysema patients, and 34 idiopathic pulmonary fibrosis (IPF) patients. The frequencies of polymorphic genotypes in MMP-9 were 78.95% CC and 21.05% CT in CPFE group, 76.0% CC and 24.0% CT in emphysema group, and 100.0% CC in IPF group. There were highly statistically significant increased frequencies of the CT genotype and T allele in CPFE and emphysema groups compared with IPF group (p < 0.05). The frequencies of polymorphic genotypes in TGF-ß1 were 2.63% CC, 28.95% CT, 68.42% TT in CPFE group, 4.00% CC, 16.00% CT, 80.00% TT in emphysema group, and 5.88% CC, 41.18% CT, 52.94% TT in IPF group. Significant increases in the TT genotype and T allele frequencies were observed in emphysema group compared with IPF group (p < 0.05). Our study has showed that T allele in MMP-9 (C-1562T) and T allele in TGF-ß1 (T869C) are risk factors of pulmonary emphysema. The T allele in MMP-9 (C-1562T) possibly predisposes patients with pulmonary fibrosis to develop emphysema.


Assuntos
Predisposição Genética para Doença , Metaloproteinase 9 da Matriz/genética , Polimorfismo de Nucleotídeo Único , Enfisema Pulmonar/genética , Fibrose Pulmonar/genética , Fator de Crescimento Transformador beta1/genética , Idoso , Idoso de 80 Anos ou mais , Alelos , Povo Asiático , Feminino , Expressão Gênica , Frequência do Gene , Humanos , Masculino , Enfisema Pulmonar/complicações , Enfisema Pulmonar/diagnóstico , Enfisema Pulmonar/etnologia , Fibrose Pulmonar/complicações , Fibrose Pulmonar/diagnóstico , Fibrose Pulmonar/etnologia , Fatores de Risco
7.
Disabil Health J ; 10(4): 492-501, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28342775

RESUMO

BACKGROUND: Young adults with disabilities face numerous barriers to independence and achieving markers of adulthood. Qualitative evidence suggests that flexible, self-directed budgets for purchasing home and community-based services might help fill an identified service gap and help improve the transition to adulthood for this group. OBJECTIVE: Our aim was to evaluate the effectiveness of the Cash and Counseling model of self-directed budgets for young adults with long-term care disabilities by analyzing secondary data from the Cash and Counseling Demonstration and Evaluation randomized control trial. METHODS: We compared nine-month community involvement, satisfaction rating, health status rating compared to peers, and unmet needs outcomes using bivariate and multivariate logistic regression. Our sample included 456 participants aged 18 to 30 randomized to treatment groups with the opportunity to receive Cash and Counseling (n = 207) or control groups eligible for agency-based care (n = 249), whether self-reported (n = 128) or by proxy (n = 328). RESULTS: Multivariate logistic regression models showed that compared to controls at nine-month follow-up, treatment group members had significantly greater odds of being very satisfied with life, when care was received, the care arrangement, transportation, help around the house and community, personal care, and getting along with paid attendants, and significantly lower odds of unmet needs with medication and routine health care at home and with transportation. CONCLUSIONS: Cash and Counseling performed better than or comparable with agency-based care for young adults with long-term care disabilities, suggesting its viability as a service option for this population.


Assuntos
Orçamentos , Pessoas com Deficiência , Financiamento Governamental , Serviços de Saúde para Pessoas com Deficiência , Serviços de Assistência Domiciliar , Vida Independente , Avaliação de Programas e Projetos de Saúde , Adolescente , Adulto , Aconselhamento , Feminino , Humanos , Modelos Logísticos , Assistência de Longa Duração , Masculino , Satisfação Pessoal , Adulto Jovem
8.
Medicine (Baltimore) ; 96(5): e5855, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28151860

RESUMO

RATIONALE: Dieulafoy disease is characterized by the presence of dilated, tortuous arteries that project into the submucosa of the gastrointestinal tract and less frequently the bronchus. PATIENT CONCERNS: Dieulafoy disease of the trachea has not been previously described. A 60-year-old woman with recurrent episodes of massive hemoptysis. DIAGNOSES: Dieulafoy disease of the trachea. INTERVENTIONS: Selective arterial embolization was undertaken. OUTCOMES: The intervention was successful and no fresh episode of acute hemoptysis was observed. LESSONS: Apart from the bronchus, vascular anomaly may also be present in the trachea in Dieulafoy disease.


Assuntos
Hemoptise/etiologia , Traqueia/irrigação sanguínea , Doenças Vasculares/complicações , Embolização Terapêutica , Feminino , Humanos , Pessoa de Meia-Idade
9.
Community Ment Health J ; 53(7): 778-781, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-28168433

RESUMO

We tested the hypothesis with a sample of community mental health clients (N = 132) that Hispanic clients would report significantly greater post-traumatic stress symptoms than African-American or white clients when controlling for gender, psychiatric symptoms of SMI, and subjective distress from six of the most commonly reported trauma in the SMI literature. Results supported our main hypothesis: being self-identified as Hispanic was significantly associated with greater post-traumatic stress symptoms. Subjective distress from having been sexually abused along with being "Hispanic" were the only two significant variables left in the equation. Limitations of this study include its modest sample size.


Assuntos
Negro ou Afro-Americano/psicologia , Hispânico ou Latino/psicologia , Transtornos de Estresse Pós-Traumáticos/etnologia , População Branca/psicologia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica , Fatores de Risco , Índice de Gravidade de Doença , Transtornos de Estresse Pós-Traumáticos/diagnóstico , Transtornos de Estresse Pós-Traumáticos/psicologia , Estados Unidos/epidemiologia
10.
COPD ; 14(2): 245-250, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28128990

RESUMO

This study aimed to explore the different pathogeneses of combined pulmonary fibrosis and emphysema (CPFE) from emphysema and pulmonary fibrosis. The levels of transforming growth factor-ß1 (TGF-ß1), vascular endothelial growth factor (VEGF), Krebs Von Den Lungen-6 (KL-6), matrix metalloproteinase-9 (MMP-9), tissue inhibitors of metalloproteinases-1 (TIMP-1), cytokeratin 19 fragment (CYFRA21-1), squamous cell carcinoma antigen (SCC), and the telomerase activity in peripheral blood were measured in 38 CPFE patients, 50 pulmonary emphysema patients, and 34 idiopathic pulmonary fibrosis (IPF) patients. The results demonstrated that the levels of VEGF and TGF-ß1 in IPF patients were significantly higher than those in emphysema patients (p < 0.05), and no significant differences were detected between CPFE patients and other two groups (p > 0.05). The levels of KL-6 and CYFRA21-1 in IPF patients were significantly higher than those in emphysema and CPFE patients (p < 0.05), and the latter had the similar levels (p > 0.05). Among the three groups, the levels of SCC, MMP-9, TIMP-1, MMP-9/TIMP-1 ratio, and telomerase activity were not different (p > 0.05). Our study showed that VEGF, TGF-ß1, KL-6, and CYFRA21-1 may play a role in the pathogenesis of pulmonary fibrosis. The lower levels of KL-6 and CYFRA21-1 in CPFE patients may be one of the reasons why these patients develop emphysema on the basis of fibrosis.


Assuntos
Biomarcadores Tumorais/sangue , Enfisema Pulmonar/sangue , Fibrose Pulmonar/sangue , Idoso , Antígenos de Neoplasias/sangue , Feminino , Humanos , Fibrose Pulmonar Idiopática/sangue , Queratina-19/sangue , Masculino , Metaloproteinase 9 da Matriz/sangue , Mucina-1/sangue , Enfisema Pulmonar/complicações , Fibrose Pulmonar/complicações , Serpinas/sangue , Telomerase/sangue , Inibidor Tecidual de Metaloproteinase-1/sangue , Fator de Crescimento Transformador beta1/sangue , Fator A de Crescimento do Endotélio Vascular/sangue
11.
Onco Targets Ther ; 9: 3077-84, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27307748

RESUMO

In recent years, long noncoding RNAs (lncRNAs) have been demonstrated to play important roles in the development of human cancer. We assessed the role of lncRNA ANRIL in non-small-cell lung cancer (NSCLC). Quantitative real-time polymerase chain reaction was employed to detect the expression of ANRIL in NSCLC tissues and paired nontumor tissues. The high expression level of ANRIL was positively correlated with advanced tumor-node-metastasis stage and greater tumor diameter. Furthermore, chromatin immunoprecipitation assays confirmed the physical interaction between c-Myc and ANRIL. ANRIL silencing significantly inhibited NSCLC cell proliferation. Together, we showed that ANRIL is involved in the oncogenesis of NSCLC, and ANRIL may be a potential therapeutic target for patients with NSCLC.

12.
Violence Against Women ; 22(10): 1211-27, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-26719079

RESUMO

In a sample of 242 women in treatment for severe mental illness (SMI), we used regression analysis to test the hypothesis that lifetime physical and sexual abuse would correlate with self-harm behaviors (thoughts of self-harm and suicide, self-harming behaviors, and suicide attempts) when controlling for psychiatric symptoms, substance abuse, and negative appraisals of trauma. Lifetime physical abuse and alcohol use were the only significant factors in the model. Women with SMI should be screened regularly for physical abuse, alcohol use, as well as thoughts and behaviors related to self-harming behaviors. Limitations of the study include its cross-sectional design.


Assuntos
Transtornos Mentais/complicações , Transtornos Mentais/psicologia , Comportamento Autodestrutivo/psicologia , Delitos Sexuais/psicologia , Adulto , Alcoolismo/etiologia , Alcoolismo/psicologia , Estudos Transversais , Feminino , Humanos , Pessoa de Meia-Idade , Análise de Regressão , Rhode Island , Delitos Sexuais/estatística & dados numéricos , Suicídio/psicologia , Suicídio/estatística & dados numéricos
13.
Chin Med J (Engl) ; 128(19): 2652-7, 2015 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-26415805

RESUMO

BACKGROUND: Compound anisodine (CA) is a compound preparation made from hydrobromide anisodine and procaine hydrochloride. The former is an M-choline receptor blocker with the function of regulating the vegetative nervous system, improving microcirculation, and so on. The latter is an antioxidant with the activities of neuroprotection. This study aimed to investigate the potential neuroprotection of CA, which affects the degeneration of the retinal ganglion cells (RGCs) in an animal model with chronic ocular hypertension. METHODS: Female C57BL/6J mice (n = 24) were divided randomly into four groups: normal control group without any treatment (Group A, n = 6); CA control group with feeding the CA solution (Group B, n = 6); microbeads (MBs) control group with injecting MB into the anterior chamber (Group C, n = 6); CA study group with MB injection and with feeding the CA solution (Group D, n = 6). Intraocular pressure (IOP) was measured every 3 days after MB injection. At the 21st day, neurons were retrograde-labeled by Fluoro-Gold (FG). Animals were sacrificed on the 27th day. Retinal flat mounts were stained immunohistologically by α2-III-tubulin. FG-retrograde-labeled RGCs, α2-III-tubulin-positive RGCs, and α2-III-tubulin-positive nerve fibers were quantified. RESULTS: Mice of Groups C and D expressed the incidence of consistent IOP elevation, which is above the IOP level of Group A with the normal one. There is no significant difference in IOP between Groups A and B (P > 0.05). On the 27th day, there were distinct loss in stained RGCs and nerve fibers from Groups C and D compared with Group A (allP < 0.001). The quantity was significantly higher in Group D as compared to Group C (allP < 0.001) but lower than Group A (allP > 0.001). There was no significant difference in the quantity of RGCs and nerve fibers between Groups A and B (allP > 0.05). CONCLUSIONS: These findings suggest that CA plays an importantly neuroprotective role on RGCs in a mouse model with chronic ocular hypertension.


Assuntos
Fármacos Neuroprotetores/farmacologia , Fármacos Neuroprotetores/uso terapêutico , Hipertensão Ocular/tratamento farmacológico , Derivados da Escopolamina/farmacologia , Derivados da Escopolamina/uso terapêutico , Animais , Sobrevivência Celular/efeitos dos fármacos , Feminino , Imuno-Histoquímica , Pressão Intraocular/efeitos dos fármacos , Camundongos , Camundongos Endogâmicos C57BL , Distribuição Aleatória , Células Ganglionares da Retina/efeitos dos fármacos
14.
Psychol Trauma ; 7(4): 348-55, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25866963

RESUMO

We tested the hypothesis that lifetime physical and sexual abuse would have direct effects on self-harm (i.e., thoughts of self-harm, self-harming behaviors, and suicide attempts) and indirect effects on self-harm via negative appraisals of trauma and psychiatric symptoms in a sample of 242 clients with severe mental illness (SMI). Structural equation modeling partly confirmed our expectations. Although there was no direct effect between abuse and self-harm, abuse and self-harm appear to be fully mediated by negative appraisal and psychiatric symptoms. Limitations to this study include the cross-sectional nature of the research, which precludes firm causal inferences regarding the relationships among these factors. Longitudinal designs are needed to understand better the direct and indirect effects of abuse on people with SMI.


Assuntos
Transtornos Mentais , Abuso Físico/psicologia , Comportamento Autodestrutivo/psicologia , Delitos Sexuais/psicologia , Feminino , Humanos , Masculino , Transtornos Mentais/epidemiologia , Pessoa de Meia-Idade , Modelos Psicológicos , Modelos Estatísticos , Análise Multivariada , Abuso Físico/estatística & dados numéricos , Comportamento Autodestrutivo/epidemiologia , Delitos Sexuais/estatística & dados numéricos
15.
Exp Lung Res ; 41(1): 44-55, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25398094

RESUMO

OBJECTIVES: We aimed to investigate the activity of regulatory T (Treg) cells in chronic Pseudomonas aeruginosa (PA) lung infection and its influence on effector T-cell responses. MATERIALS AND METHODS: C57BL/6 mice were randomly inoculated with PA-laden agarose beads (1 × 10(5) CFU/50 µL) or planktonic PA (1 × 10(5) CFU/50 µL), and euthanized at the time points of 4 hour, day 1, 3, 5, and 7. Bacterial load, bronchoalveolar lavage (BAL) fluid cell counts, and lung tissue histology were assessed. BAL fluid concentrations of TGF-ß1, IFN-γ, IL-1ß, IL-4, IL-6, IL-10, and IL-17A were measured. Messenger RNA (mRNA) levels of TGF-ß1, IL-10 and CD4(+) T-cell subtype-specific transcription factors were determined. The expression of CD4(+)CD25(+)forkhead box P3 (FoxP3)(+) cells in lungs and spleens were analyzed. RESULTS: Mice inoculated with PA-laden agarose beads developed chronic PA lung infection during 7-day study period, while mice inoculated with planktonic PA cleared bacteria in 3 days. Compared with mice recovered from acute PA lung infection, those with chronic infection had significantly increased effector T-cell responses, accompanied by a more severe neutrophilic inflammation. Mice with chronic PA lung infection had significantly lower concentration of TGF-ß1 and higher concentrations of IFN-γ, IL-1ß, IL-6, and IL-17A in BAL fluid. Meanwhile, they had significantly lower mRNA levels of TGF-ß1, IL-10 and FoxP3 in lung tissues, and lower expression of CD4(+)CD25(+)FoxP3(+) cells in lungs and spleens. CONCLUSIONS: These findings indicate that Treg cell activity is partly inhibited in mice with chronic PA lung infection, which contributes to the enhanced effector T-cell responses in airways.


Assuntos
Pneumonia Bacteriana/imunologia , Infecções por Pseudomonas/imunologia , Linfócitos T Reguladores/fisiologia , Animais , Doença Crônica , Citocinas/metabolismo , Modelos Animais de Doenças , Feminino , Fatores de Transcrição Forkhead/metabolismo , Interleucina-10/metabolismo , Camundongos Endogâmicos C57BL , Pneumonia Bacteriana/metabolismo , Pneumonia Bacteriana/microbiologia , Infecções por Pseudomonas/metabolismo , Infecções por Pseudomonas/microbiologia , Pseudomonas aeruginosa , Distribuição Aleatória , Linfócitos T Auxiliares-Indutores/metabolismo , Fator de Crescimento Transformador beta1/metabolismo
16.
Am J Orthopsychiatry ; 84(6): 664-73, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25110974

RESUMO

Research on the impact of sudden or unexpected losses in people with severe mental illness is scarce. The purpose of our study was to examine the relationship between subjective distress from sudden losses in people with severe mental illness and posttraumatic stress symptoms while controlling for gender, psychiatric symptoms, and negative appraisals. As part of routine care, treatment personnel collected data from 371 community mental health clients diagnosed with a severe mental illness. Hierarchical linear regression revealed that negative appraisals of the self and the world correlated significantly with posttraumatic stress symptoms, and distress from losses accounted for the greatest amount of variance in posttraumatic stress symptoms of the 6 traumas tested. When examined by diagnostic group, only those with schizophrenia spectrum disorder showed a significant association between distress from sudden losses and posttraumatic stress symptoms. Relative to other factors including symptoms of severe mental illness, distress from sudden losses in people with severe mental illness appears to be strongly associated with posttraumatic stress symptoms.


Assuntos
Acontecimentos que Mudam a Vida , Transtornos Mentais/psicologia , Autoimagem , Transtornos de Estresse Pós-Traumáticos/psicologia , Adulto , Luto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Esquizofrenia/fisiopatologia
17.
Tumori ; 100(3): 338-45, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25076248

RESUMO

AIMS AND BACKGROUND: The aim of this study was to find disease-associated genes and gene functions in lung adenocarcinoma and matched adjacent non-tumor lung tissues with DNA microarray. METHODS: We downloaded the gene expression profile GSE32863 from the Gene Expression Omnibus database including 58 lung adenocarcinoma and 58 adjacent non-tumor lung tissue samples. Data were preprocessed and the differentially expressed genes (DEGs) were identified using packages in the R computing language. The selected DEGs were further analyzed with bioinformatics methods. After the coexpression network of DEGs was constructed by STRING (Search Tool for the Retrieval of Interacting Genes/Proteins), we analyzed gene functions with DAVID (The Database for Annotation, Visualization and Integrated Discovery) and WebGestalt (WEB-based Gene Set Analysis Toolkit). RESULTS: A total of 1429 genes were filtered as DEGs, including 873 downregulated genes and 556 upregulated genes, and the DEGs including CDC45, CCNB2, CDC20, MCM2, PTTG1, MCM4 and FEN1 were most significantly related to cell cycle and DNA replication. CONCLUSION: The discovery of featured genes which were significantly related to cell cycle and DNA replication has potential for use in the clinic for the diagnosis of lung adenocarcinoma in the future. However, further experiments will be needed to confirm our result.


Assuntos
Adenocarcinoma/genética , Perfilação da Expressão Gênica , Genes cdc , Neoplasias Pulmonares/genética , Pulmão/metabolismo , Adenocarcinoma de Pulmão , Adulto , Idoso , Proteínas Cdc20/genética , Proteínas de Ciclo Celular/genética , Ciclina B2/genética , Feminino , Endonucleases Flap/genética , Regulação Neoplásica da Expressão Gênica , Humanos , Masculino , Análise em Microsséries , Pessoa de Meia-Idade , Componente 2 do Complexo de Manutenção de Minicromossomo/genética , Componente 4 do Complexo de Manutenção de Minicromossomo/genética
18.
Community Ment Health J ; 50(6): 673-80, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24282033

RESUMO

We examined associations among six forms of common lifetime traumatic/adverse events and lifetime suicide attempts while controlling for gender, psychiatric symptoms, self-injury, and substance use in 371 community mental health clients with severe mental illness. Most clients (88.1%) reported at least one traumatic event, and more than half had attempted suicide at least once. Regression revealed that three factors were significantly associated with lifetime suicide attempts: lifetime self-injurious behaviors, lifetime physical abuse, and alcohol use. Having been physically abused appears to be uniquely associated with lifetime suicide attempts when other key risk factors are controlled. Limitations include the cross-sectional design.


Assuntos
Acontecimentos que Mudam a Vida , Transtornos Mentais/psicologia , Tentativa de Suicídio/estatística & dados numéricos , Consumo de Bebidas Alcoólicas/efeitos adversos , Consumo de Bebidas Alcoólicas/psicologia , Serviços Comunitários de Saúde Mental/estatística & dados numéricos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Comportamento Autodestrutivo/complicações , Comportamento Autodestrutivo/psicologia , Fatores Sexuais , Tentativa de Suicídio/psicologia , Violência/psicologia
19.
Chin Med J (Engl) ; 126(17): 3301-6, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24033953

RESUMO

BACKGROUND: Managements of optic neuritis (ON) included high-dose corticosteroids or combined with systemic immunomodulatory agents. It was important to make a correct diagnosis of ON before initiation of treatment. The purpose of the study was to report and analyze the clinical features of retinal diseases in patients who were misdiagnosed as having retrobulbar ON. METHODS: Retrospective review of 26 patients (38 eyes) initially diagnosed with retrobulbar ON but were ultimately diagnosed with retinal or macular diseases. Data obtained from fundus examination, fluorescence fundus angiography (FFA), automated static perimetry, full-field electroretinogram (ffERG), multifocal electroretinogram (mfERG), and optical coherence tomography (OCT) were evaluated. RESULTS: Thirty-eight eyes of 26 patients were found to have misdiagnosis of retrobulbar ON, based on normal or slight abnormal fundus findings and abnormal visual evoked potentials (VEP). The mean age of the patients was 34 years and the correct diagnosis of the patients included acute zonal occult outer retinopathy (AZOOR, 15 eyes, 14 patients), occult macular dystrophy (OMD, 8 eyes, 4 patients), cone or cone-rod dystrophy (10 eyes, 5 patients), acute macular neuroretinopathy (AMNR, 3 eyes, 2 patients), and cancer-associated retinopathy (CAR, 2 eyes, 1 patient). CONCLUSION: When attempting to diagnose retrobulbar ON in clinical practice, it is crucial to carry out necessary examinations of the retinal function and morphology to decrease misdiagnosis.


Assuntos
Neurite Óptica/diagnóstico , Doenças Retinianas/diagnóstico , Adulto , Idoso , Eletrorretinografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Tomografia de Coerência Óptica
20.
Exp Lung Res ; 39(6): 241-8, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23672275

RESUMO

BACKGROUND: Elevated levels of KL-6 are reported in the serum and/or bronchoalveolar lavage fluid (BALF) of patients with interstitial lung disease (ILD) and are useful to estimate the severity and prognosis of the disease. However, whether the anti-KL-6 antibody could attenuate pulmonary fibrosis remains unclear. OBJECTIVES: This study aims to investigate the therapeutic effects and mechanisms of anti-KL-6 antibody on bleomycin-induced pulmonary fibrosis. METHODS: A mouse model of pulmonary fibrosis was established by intratracheal injection of bleomycin (5 mg/kg). Mouse received anti-KL-6 antibody (20 ug/day, once a day) from day 7 to 21 after bleomycin injection. The effects of anti-KL-6 antibody were evaluated by pathological examination, measuring hydroxyproline measurements in lung tissues, leukocyte counts in BALF and the expression of collagen type I and type III using qRT-PCR. The expression of profibrotic cytokine (transforming growth factor-ß1, TGF-ß1), antifibrotic cytokine (hepatocyte growth factor, HGF), and KL-6 in lung tissues were analyzed by ELISA. The apoptosis of epithelial cell was examined by TUNEL staining. RESULTS: Anti-KL-6 antibody significantly reduced the number of alveolar inflammatory leukocytes (total and differential counts) in BALF of mice with bleomycin-induced pulmonary fibrosis as well as the content of hydroxyproline in the lung tissues. Treatment with anti-KL-6 antibody downregulated the expression of collagen type I, TGF-ß1 and KL-6, upregulated the expression of HGF and inhibited the apoptosis of epithelial cells. CONCLUSIONS: These findings indicated the anti-KL-6 antibody may potentially be developed as a useful inhibitor of pulmonary fibrosis.


Assuntos
Anticorpos Monoclonais/farmacologia , Bleomicina/toxicidade , Mucina-1/imunologia , Fibrose Pulmonar/prevenção & controle , Células Epiteliais Alveolares/efeitos dos fármacos , Células Epiteliais Alveolares/metabolismo , Células Epiteliais Alveolares/patologia , Animais , Apoptose/efeitos dos fármacos , Bleomicina/antagonistas & inibidores , Líquido da Lavagem Broncoalveolar/química , Líquido da Lavagem Broncoalveolar/citologia , Colágeno Tipo I/genética , Colágeno Tipo I/metabolismo , Colágeno Tipo III/genética , Colágeno Tipo III/metabolismo , Citocinas/metabolismo , Modelos Animais de Doenças , Expressão Gênica/efeitos dos fármacos , Hidroxiprolina/metabolismo , Pulmão/efeitos dos fármacos , Pulmão/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Fibrose Pulmonar/induzido quimicamente , Fibrose Pulmonar/imunologia , Organismos Livres de Patógenos Específicos
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