[Effect of Qufu Shengji ointment(QFSJO) on promoting the healing of infectious wounds].

OBJECTIVE: To explore the clinical effect of Qufu Shengji ointment(QFSJO) in promoting the wound healing after trauma. METHODS: From January 2014 to June 2018, 60 patients with soft tissue injury, skin defect and wound infection caused by violent trauma were admitted, including 32 males and 28 females, aged from 18 to 65 years, with an average age of 41.3 years. Among them, 30 patients were treated with QFSJO (QFSJO group) and 30 patients were treated with normal saline iodophor (control group). The reduction rate of wound area, the days of decayed flesh, the time of new epithelium and the recovery rate of 28 days after dressing change were compared between the two groups. RESULTS: In the QFSJO group, after using large dose of QFSJO, the pus of the wound increased, the granulation grew, and the new epithelium appeared on the edge of the wound, showing a rapid healing phenomenon. The wound healing rate of QFSJO group was higher than that of the control group at all time points, and the time of decaying flesh and new epithelium appeared in QFSJO group was earlier than that of the control group. The recovery rate of QFSJO group was significantly higher than that of the control group(P<0.05). All the patients were followed up, and the duration ranged form 6 to 12 months, with an average of 9.4 months. The exposed areas of bone and teadon were covered well. The vital signs of the two groups were stable and no adverse reactions occurred. CONCLUSIONS: QFSJO can promote the growth of granulation tissue, promote the production of new skin, and accelerate the healing of infectious wound after trauma.

[Raman spectroscopy analysis of impact of UV radiation on linoleic acid oxidation].

The authors studied on self oxidation of linoleic acid and the effect of UV irradiation on oxidation of linoleic by Raman spectroscopy. The result reflects that:the intensity of 1 266 cm' which stands for ==CH olenic hydrogen in-plane bend is diminished, and it disappeared at 72 hours after the oxidation beginning. That indicates that double bond was lost or reduced. upsilon(C==C) and the carboxylic acid C==O vibrations are lies in 1 658 cm(-1). The intensity of 1 658 cm(-1) was increased in the beginning and decreased then. At the initial stage in the reaction, rearrangement of carbon chains and the formation of carboxylic acids caused the increasing. Later in the reaction, carboxyl of linoleic acid reacted with the generated hydroxy acids, hydroxy aldehyde. So it decreased. UV irradiation accelerated the oxidation reaction starting, increased the speed of the oxidation reaction. All the result shows that the changes of Raman spectroscopy indicate the changes of bulky group in fatty acid oxidation process and the effect of UV irradiation. It provides an effective research tool for the mechanism of lipid peroxidation reaction.