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1.
Artigo em Inglês | MEDLINE | ID: mdl-38698225

RESUMO

PURPOSE: To determine the variation of OXIS contact areas in primary molars using digital impressions generated from an intraoral scanner (IOS). METHODS: A cross-sectional study was carried out on 214 caries-free posterior quadrants of 80 children (38 males and 42 females) aged 3-6 years. Calibration of taking digital impressions with the IOS procedure was performed initially through scanning of ten quadrants of children to provide a learning environment to the examiner. The digital impressions were then exported, and the type of interproximal contact areas present between the distal surface of the primary first molar and the mesial surface of the primary second molar were identified according to the OXIS classification. The prevalence of the types of OXIS contact areas was expressed in the form of numbers and percentages. The chi-square test was applied to investigate the variability among the arches and to understand the association of OXIS contact areas across age, gender, and arches. RESULTS: The most common contact area type observed was I-type (59.8%), followed by S-type (15.4%), X-type (12.6%), and O-type (12.2%). The I-type contact area was most frequently seen in both males (51.6%) and females (65.5%), while the S-type contact area in males (14.7%) and X-type contact area in females (8.4% each) were the least frequent with no statistical significance between genders (p > 0.05). All three age groups studied showed the highest prevalence of the I-type contact area, which increased with an increase in age (p < 0.05). The inter-arch comparison showed a significant result in terms of the X-type contact area on the right side, and O-type, X-type, and I-type contact areas on the left side, while no statistical difference was seen in the intra-arch comparison for all contact types. CONCLUSION: I-type contact areas were the most prevalent across the arches, age groups and genders.

2.
Eur J Paediatr Dent ; 25: 1, 2024 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-38197569

RESUMO

AIM: To assess the reliability and validity of an AI-based, innovative digital scale for the assessment of dental anxiety in children. BACKGROUND: Dental anxiety still persists as a potential problem in managing the child in the dental office. There is a need to develop a gold standard scale to measure anxiety in children incorporating newer technology. An innovative self-reported scale known as RMSDigital Anxiety Scale (RMS-DAS) incorporating artificial intelligence (AI) was developed. METHODS: Seventy-six children (aged 4-12 years) were included in the reliability group. The RMS-DAS test score was recorded on Day 1 where the child was asked to click on the expression produced by AI that matches his/her anxiety level the most at that moment. RMS-DAS retest score was recorded after 7 days. The validity group included 140 children. The anxiety scores were recorded using three scales; RMS-DAS, RMS-Pictorial Scale (RMS-PS) and Facial Image Scale (FIS) during the same visit where the child was asked to click on the expression that matches his/her anxiety level the most at that moment. Reliability was assessed by the internal consistency using Cronbach's alpha and the test-retest was assessed using paired t-test, scatterplot, and coefficient correlation. The validity of RMS-DAS was assessed by correlating it with RMS-PS and FIS using Spearman's correlation coefficient. CONCLUSION: RMS-DAS is a reliable and valid scale that can be used as a new digital tool to assess children's dental anxiety.


Assuntos
Ansiedade , Inteligência Artificial , Feminino , Criança , Humanos , Masculino , Reprodutibilidade dos Testes , Ansiedade/diagnóstico , Autorrelato
3.
Eur Arch Paediatr Dent ; 25(1): 75-84, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38281253

RESUMO

BACKGROUND: Digit sucking is a common oral habit among many children, which involves placing the thumb/finger into the mouth, which can cause malocclusion in mixed and permanent dentition. AIM: To evaluate the efficacy of the RURS elbow guard in the management of thumb-sucking habits in children with intellectual disabilities and those without in terms of the mean duration of appliance therapy. The secondary objective was to compare the RURS elbow guard with an intraoral crib in healthy children (without intellectual disabilities) to manage the habit of thumb-sucking. DESIGN: Children with intellectual disabilities and those without between the age of 4 and 16 years were included in the study and categorised into three groups, namely group I (50 normal children; intraoral crib appliance), group II (50 normal children; RURS elbow guard) and group III (50 children with intellectual disabilities; RURS elbow guard). RESULTS: The mean duration of appliance therapy for groups I, II and III were 200.20 ± 20.43 days, 204.34 ± 20.56 days, and 218.43 ± 15.66 days, respectively (p < 0.001). The differences in the mean duration between group I and group II were statistically non-significant, with statistically significant differences between group I and group III (p < 0.001) and between group II and group III (p < 0.05). CONCLUSION: The RURS elbow guard was found to be an efficient appliance in treating thumb-sucking among children who had mild to moderate intellectual disabilities. RURS elbow guard was equally efficient as an intraoral crib appliance in managing thumb-sucking habits in children without intellectual disabilities.


Assuntos
Deficiência Intelectual , Má Oclusão , Criança , Humanos , Pré-Escolar , Adolescente , Cotovelo , Deficiência Intelectual/complicações , Polegar , Hábitos , Sucção de Dedo/terapia
4.
Eur J Paediatr Dent ; : 1, 2023 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-37212627

RESUMO

AIM: There is a lack of sufficient information about the protocols followed by paediatric dentists in informing parents about traumatic dental injuries as a part of anticipatory guidance. Hence, the aim of this study was to assess paediatric dentists' attitudes and practices about parental guidance regarding these injuries. MATERIALS: This was a cross-sectional survey conducted using a validated questionnaire emailed through Google form to approximately 2500 paediatric dentists in various world regions. The sampling method used was a list-based sampling frame followed by simple random sampling. Participants were recruited through national member societies of the International Association of Paediatric Dentistry, personal contacts and social media groups. Only paediatric dentists with at least three years of experience after their post-graduation were only included in the study. Their attitudes and practices towards parental education on dental trauma during the child's first and recalled dental visits were assessed as per their age, gender, country of post-graduation qualification and years of experience in the profession. Chi-Square test was used to evaluate the association between the paediatric dentist response and the continent of practice. Kruskal-Wallis H test was used to assess the level of significance within each variable in relation to the continent of practice. A 95% confidence interval with a significance level of α = 0.05 was used. CONCLUSION: The overall attitude and practice of paediatric dentists toward parental education on traumatic dental injuries were not satisfactory. Many paediatric dentists do not impart education on emergency care and dental trauma prevention in primary teeth. Parents should be informed about oral hygiene instructions and prevention-oriented interventions during the first visit and about managing traumatic dental injuries.

6.
Eur Spine J ; 32(4): 1099-1105, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36843147

RESUMO

PURPOSE: Foot drop can uncommonly be a painless presenting symptom of degenerative spinal disorders. This systematic review aimed to summarise the literature on the management and outcomes of patients with a painless foot drop. METHODS: We performed a systematic review of PubMed, EMBASE and Medline according to PRISMA guidelines. All studies published after 1980 in English referring to adult patients with a painless foot drop were included. Exclusion criteria included opinion based reports, review articles and articles in which foot drop was not caused by degenerative pathology of the thoracolumbar spine. RESULTS: Of 62 included patients, 30 (48.4%) were male with an average age of 48.7 years (range 27-84). The mean duration of symptoms was 69.0 days (1-700). 98.8% were managed operatively. 46 (74.2%) patients had symptomatic improvement, with 41 (66.1%) having a post-intervention MRC power grading of 3 or above. Patients with a pre-procedure MRC 0 had a higher median increase in MRC post-procedure than those with MRC > 0. Of two studies comparing painful and painless symptoms, painless foot drop patients were less likely to recover to MRC equal to or over 3 than those with painful symptoms OR 0.31 (95% CI 0.04-2.65). CONCLUSION: This systematic review and meta-analysis demonstrates a role for surgery in facilitating the neurological recovery of patients with a painless foot drop. Large randomised controlled studies are required to characterise the role of operative intervention in these patients and compare outcomes between patients with painless and painful foot drop.


Assuntos
Doenças da Coluna Vertebral , Adulto , Humanos , Masculino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Feminino , Doenças da Coluna Vertebral/cirurgia
9.
Vaccine X ; 12: 100216, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36164460

RESUMO

Background: Combination vaccines reduce the number of pediatric injections but must be as safe, immunogenic, and effective as each of the individual vaccines given separately. Additionally, consistency in manufacturing lots is essential for WHO prequalification. This study aimed to establish the lot-to-lot consistency of a fully liquid, hexavalent diphtheria (D)-tetanus (T)-whole-cell pertussis (wP)-inactivated poliovirus (IPV)-hepatitis B (HB)-Haemophilus influenzae b (PRP-T) (DTwP-IPV-HB-PRP∼T) vaccine and to demonstrate non-inferiority to licensed DTwP-HB-PRP∼T and IPV vaccines. Methods: A Phase III, randomized, active-controlled, and open-label study was conducted at multiple centers across India. Healthy infants who had received a birth dose of oral poliovirus vaccine and hepatitis B vaccine received one of three lots of DTwP-IPV-HB-PRP∼T or separate DTwP-HB-PRP∼T and IPV vaccines at 6-8, 10-12, and 14-16 weeks of age. Oral rotavirus vaccine was co-administered at 6-8 weeks of age and 10-12/14-16 weeks of age. DTwP-IPV-HB-PRP∼T lot-to-lot consistency and non-inferiority (pooled DTwP-IPV-HB-PRP∼T) versus DTwP-HB-PRP∼T and IPV post-third dose were assessed using seroprotection rates (anti-D, anti-T, anti-HBs, anti-PRP, anti-polio 1, 2, 3) and adjusted geometric mean concentrations (anti-PT, anti-FIM). Safety was assessed by parental reports. Results: Lot-to-lot consistency was demonstrated for DTwP-IPV-HB-PRP∼T and non-inferiority versus DTwP-HB-PRP∼T and IPV was confirmed with 95% CIs for seroprotection rate differences and adjusted geometric mean concentration ratios within pre-defined clinical margins. Pooled seroprotection rate was ≥ 99.7% for anti-D ≥ 0.01 IU/mL, anti-T ≥ 0.01 IU/mL, anti-HBs ≥ 10 mIU/mL, anti-PRP ≥ 0.15 µg/mL, and anti-polio 1, 2, and 3 ≥ 8 (1/dil) and vaccine response rate was 83.9% for anti-PT and 97.7% for anti-FIM. There were no safety concerns. Conclusions: Immunogenicity of three lots of the fully liquid DTwP-IPV-HB-PRP∼T vaccine was consistent and non-inferior to licensed comparators following vaccination at 6-8, 10-12, and 14-16 weeks of age. There were no safety concerns and no evidence of any effect of co-administration with rotavirus vaccine.

10.
Niger J Clin Pract ; 24(6): 866-873, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34121735

RESUMO

AIM: To evaluate the effect of prosthetic framework material and cantilever length on peri-implant strain in mandibular all-on-four implant-supported prostheses with different types of arch antagonist forces. MATERIALS AND METHODS: Models simulating a completely edentulous mandibular arch fabricated in heat-cured acrylic resin were used. On the acrylic models, four implants were placed at regions 34, 32, 42, and 44 simulating all-on-four implant placements. Implant-supported screw-retained fixed prosthesis frameworks were fabricated using three different materials (cobalt-chromium, zirconia, and polyetheretherketone) and with three different cantilever lengths (zero mm, 15 mm, and 25 mm). Strain gauges were attached on the model at the buccal and lingual positions of each implant. Forces simulating opposing natural dentition, conventional complete denture, and the parafunctional habit were applied to the models. The peri-implant strain in each strain gauge was recorded. RESULTS: Least peri-implant strains (67 microstrains) were observed when forces simulating conventional complete dentures were applied on the models and the highest peri-implant strains (9091 microstrains) were observed when forces simulating parafunctional habit were applied. One-way ANOVA test followed by Tukey's post hoc analysis was performed to compare the mean deformation scores between different materials at 50 N load. The level of significance [P-value] was set at P < 0.05. Tests showed significant differences between zero mm and the other types in all the different materials, and also between 1.5 x AP and 2.5 x AP for Zirconia and Peek material at P = 0.02 & P = .008, respectively. The results showed that the type of framework material, cantilever length, and occlusal forces from the opposing arch influence the peri-implant strain in the bone in all-on-four implant-supported prostheses. CONCLUSION: Rehabilitation of a single, completely edentulous arch with implant-supported prostheses should consider the situation of the opposing arch. The choice of framework material, as well as the cantilever length, should be altered based on the forces from the opposing arch.


Assuntos
Implantes Dentários , Prótese Total , Resinas Acrílicas , Força de Mordida , Parafusos Ósseos , Prótese Dentária Fixada por Implante , Humanos , Mandíbula/cirurgia
11.
Eur Arch Paediatr Dent ; 21(3): 303-311, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31625121

RESUMO

PURPOSE: To evaluate craniofacial and occlusal features of children with sickle cell disease and compare them with the normal healthy children. METHODS: A total of 50 children diagnosed with sickle cell disease (Group I) and 50 normal healthy children (Group II) between age 10 and 18 years were included in the study. Dental casts were obtained, occlusal traits were recorded and DAI and DHC-IOTN were calculated. Cephalometric parameters were measured. Obtained data were compared between the two groups. RESULTS: In children with sickle cell disease, 24% had definite malocclusion according to DAI and only 4% of them had normal occlusion as per the DHC-IOTN index. Also, children with sickle cell had significant retruded mandible and vertical growth pattern when compared with normal children. CONCLUSIONS: Children with sickle cell disease showed delayed eruption of teeth, a tendency towards Class II molar relationship, with increased crowding in the lower anterior region, increased overjet and open bite when compared to the normal children. Children with sickle cell disease had severe and handicapping malocclusion as per DAI and DHC-IOTN indices and a tendency towards skeletal Class II with a vertical growth pattern.


Assuntos
Anemia Falciforme , Má Oclusão Classe II de Angle , Má Oclusão , Mordida Aberta , Cefalometria , Criança , Humanos
12.
Photodiagnosis Photodyn Ther ; 28: 265-272, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31585175

RESUMO

BACKGROUND: Sterilization of the root canal system is of prime importance for a successful root canal therapy. Lasers and photodynamic therapy (PDT) have become the latest choice to eradicate microorganisms in the root canal. OBJECTIVE(S): To evaluate and compare the antimicrobial activity of diode laser, photodynamic therapy, and sodium hypochlorite along with their combinations on endodontic pathogens: Enterococcus faecalis and Streptococcus mutans. METHODS: A total of 120 uniradicular teeth were stored in 5.2% NaOCl solution to remove organic residues and the crowns were sectioned at the cemento-enamel junction (CEJ) to obtain root canal length of 15 mm. Canals were shaped using step-back technique up to #40 K-file and were autoclaved. The selected teeth (specimen) were randomly divided into two equal groups with sixty teeth being inoculated with E. faecalis (Group E) and remaining sixty teeth with S. mutans (Group S). Further, the groups were subdivided according to the disinfection technique used. Ten teeth from each subgroup were disinfected with a diode laser, photo activated disinfection (PAD), sodium hypochlorite, a combination of sodium hypochlorite and diode laser, a combination of sodium hypochlorite and photo activated disinfection respectively. Ten teeth in each group served as control without any disinfection. The treated specimens were transferred to test tubes containing 5 ml sterile Luria Bertani broth, incubated and the bacterial count, optical density in each root specimen was calculated and compared. The pairwise comparison of colonies across the subgroups was done by the Kruskal-Wallis test and within the subgroups was carried out using the Mann-Whitney U test. The statistical implication was tested at 5% and the study was performed using SPSS 18.0 ver. (SPSS Inc.). RESULTS: A significant reduction (98%) in the E. faecalis count was observed when the NaOCl was used in combination with the diode laser or PAD. PAD along with 3% NaOCl presents the advantage of utilizing a lower wavelength laser beam. Hence, PAD in combination with NaOCl can be an alternative and better option for root canal disinfection for both the endodontic pathogens, E. faecalis and S. mutans.


Assuntos
Cavidade Pulpar/efeitos dos fármacos , Cavidade Pulpar/efeitos da radiação , Desinfecção/métodos , Fotoquimioterapia/métodos , Irrigantes do Canal Radicular/farmacologia , Hipoclorito de Sódio/farmacologia , Contagem de Colônia Microbiana , Cavidade Pulpar/microbiologia , Enterococcus faecalis , Humanos , Técnicas In Vitro , Lasers Semicondutores , Streptococcus mutans
13.
Eur Arch Paediatr Dent ; 20(5): 409-415, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30637684

RESUMO

OBJECTIVES: To determine the acquisition of Streptococcus mutans and dental caries experience in children with sickle cell anaemia (SCA) under various prophylactic therapies. METHODS: This study involved a total of 200 children who were divided into five groups comprising of 40 children each. Group SP included children who received prophylactic penicillin, Group SV who received pneumococcal vaccination, Group SPV who received both prophylactic penicillin and pneumococcal vaccination, Group SW who did not receive any prophylactic therapy and Group CC who were controls. Stimulated saliva samples from volunteers were collected and cultured in Mitis Salivarius Bacitracin (MSB) agar for estimation of Streptococcus mutans. Decayed, Missing, Filled (DMFT) index/decayed, exfoliated, and filled tooth (deft) index was used for assessment of dental caries. RESULTS: Group SP, Group SV, and Group SPV showed statistically significant difference in Streptococcus mutans count and dental caries experience in children when compared to Group SW and Group CC (p < 0.05) with the maximum reduction in Group SPV. No significant differences were observed in Group SW and Group CC. CONCLUSIONS: Reduction in the Streptococcus mutans acquisition and dental caries experience was seen in children with SCA who received prophylactic therapy with the least acquisition in combination therapy (Group SPV).


Assuntos
Anemia Falciforme , Cárie Dentária , Criança , Contagem de Colônia Microbiana , Índice CPO , Humanos , Saliva , Streptococcus mutans
14.
J Contemp Dent Pract ; 19(5): 507-514, 2018 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-29807959

RESUMO

AIM: The aim of the study was to evaluate the fracture strength of three types of composite core build-up materials. The objectives were to study and evaluate the fracture strength and type of fracture in composite core build-up in restoration of endodonti-cally treated teeth with or without a prefabricated metallic post. MATERIALS AND METHODS: A total of 60 freshly extracted mandibular premolars free of caries, cracks, or fractures were end-odontically treated and restored with composite core build-up with prefabricated metallic posts cemented with resin luting cement (group I) and without a post (group II). This was followed by a core build-up of 10 teeth each with three different types of composite materials: Hybrid composite, nanocomposite, and ormocer respectively. The samples were mounted on polyvinyl chloride block and then loaded in the universal load frame at 90° to the long axis of tooth. The fracture strength of the samples was directly obtained from the load indicator attached to the universal load frame. RESULTS: Analysis of variance (ANOVA) test revealed that teeth restored with post exhibited highest fracture strength (1552.32 N) and teeth restored without post exhibited lowest fracture strength (232.20 N). Bonferroni's test revealed that values for hybrid composite (Z-100, 3M ESPE) with post, nanocomposite (Z-350, 3M ESPE) with post, ormocer composite (Admira-VOCO) with post, and nanocomposite (Z-350, 3M ESPE) without post were not significantly different from each other. CONCLUSION: Teeth restored with post and core using hybrid composite yielded the highest values for fracture strength. Teeth restored with ormocer core without post exhibited the lowest values. Teeth restored with nanocomposite core without post exhibited strength that was comparable with hybrid composite core but higher than that of ormocer. CLINICAL SIGNIFICANCE: Mutilated endodontically treated teeth can be prosthetically rehabilitated successfully by using adhesive composite core build-up along with post to meet anatomical, functional, and esthetic demands.


Assuntos
Resinas Acrílicas , Resinas Compostas , Materiais Dentários , Resistência à Flexão , Teste de Materiais , Poliuretanos , Técnica para Retentor Intrarradicular , Restauração Dentária Permanente , Análise do Estresse Dentário , Estética Dentária , Técnicas In Vitro , Nanoestruturas , Cerâmicas Modificadas Organicamente , Dente não Vital
15.
Cell Mol Biol (Noisy-le-grand) ; 63(7): 94-101, 2017 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-28838347

RESUMO

Synaptosomal and mitochondrial impairments in the brain of diabetic individual manifest metabolic risk factors that most likely affect the brain functions. Diabetes is associated with the structural and functional alterations of the brain and neuronal loss leading to cognitive and other behavioral impairments, thus reducing the quality of life. The biochemical mechanisms underlying the diabetes-associated behavioral decline are poorly understood. In the present study, we examined the effects of hyperglycemia on the oxidative stress and behavioral functions in streptozotocin-induced diabetic mice. Our results showed the increase in oxidative stress in synaptosomes and brain mitochondria marked by an increase in lipid peroxidation and protein carbonyl content and decline in reduced glutathione in mice treated with streptozotocin. The oxidative damage in synaptosomes and brain mitochondria further caused impairment in locomotor and memory behavioral functions. Furthermore, we examined the protective effects of plant extract derived from Malvastrum tricuspidatum against STZ induced oxidative stress and behavioural impairments. For the first time we showed that this plant extract attenuate synaptosomal and mitochondrial oxidative stress and behavioral impairments in mice treated with streptozotocin. We suggest that streptozotocin caused impairments in synaptosomes and brain mitochondria and altered behavioral functions via increase in the oxidative stress and decrease in the antioxidant defense system. These impairments in synaptosomes and brain mitochondria and alterations in behavioral functions are significantly prevented by supplementation of Malvastrum tricuspidatum extract.


Assuntos
Comportamento Animal , Diabetes Mellitus Experimental/tratamento farmacológico , Diabetes Mellitus Experimental/patologia , Malvaceae/química , Mitocôndrias/metabolismo , Estresse Oxidativo , Extratos Vegetais/uso terapêutico , Sinaptossomos/metabolismo , Animais , Glutationa/metabolismo , Peroxidação de Lipídeos/efeitos dos fármacos , Locomoção/efeitos dos fármacos , Masculino , Camundongos , Mitocôndrias/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Extratos Vegetais/farmacologia , Carbonilação Proteica/efeitos dos fármacos , Estreptozocina , Sinaptossomos/efeitos dos fármacos
16.
Cell Mol Biol (Noisy-le-grand) ; 62(1): 73-83, 2016 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-26828992

RESUMO

Hypothalamus, the primary brain region for glucose sensing, is severely affected by oxidative stress in diabetes mellitus. Oxidative stress in this region of brain may cause severe impairment in neuronal metabolic functions. Mitochondria are prominent targets of oxidative stress and the combination of increased oxidative stress and mitochondrial dysfunctions may further decline hypothalamic neuronal functions. In the present study we examined the oxidative damage response, antioxidative responses and mitochondrial membrane permeability transition in hypothalamus of streptozotocin-treated diabetic rats. Our results show that streptozotocin significantly increases hypothalamic lipid peroxidation, protein carbonyl content while glutathione peroxidase and reduced glutathione were declined. Mitochondrial impairment marked by an increase in mitochondrial membrane permeabilization was seen following streptozotocin treatment in the hypothalamus. The oral administration of Withania somnifera root extract stabilized mitochondrial functions and prevented oxidative damage in the hypothalamus of diabetic rat. These findings suggest an increase in the oxidative stress and decline in antioxidative responses in the hypothalamus of streptozotocin treated diabetic rats. Withania somnifera root extract was found useful in reducing oxidative stress and mitochondrial impairment in hypothalamus of diabetic rat.


Assuntos
Antioxidantes/farmacologia , Diabetes Mellitus Experimental/tratamento farmacológico , Hipotálamo/efeitos dos fármacos , Mitocôndrias/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Extratos Vegetais/farmacologia , Withania/química , Animais , Permeabilidade da Membrana Celular/efeitos dos fármacos , Diabetes Mellitus Experimental/induzido quimicamente , Diabetes Mellitus Experimental/metabolismo , Glutationa/metabolismo , Glutationa Peroxidase/metabolismo , Hipotálamo/metabolismo , Peroxidação de Lipídeos/efeitos dos fármacos , Mitocôndrias/metabolismo , Oxirredução/efeitos dos fármacos , Raízes de Plantas/química , Carbonilação Proteica/efeitos dos fármacos , Ratos , Ratos Wistar , Estreptozocina/farmacologia
17.
Eye (Lond) ; 30(5): 705-12, 2016 05.
Artigo em Inglês | MEDLINE | ID: mdl-26915747

RESUMO

PurposeTo study the outer retinal tubules using spectral domain optical coherence tomography and adaptive optics and in patients with Bietti's crystalline dystrophy.MethodsTen eyes of five subjects from five independent families with Bietti's crystalline Dystrophy (BCD) were characterized with best-corrected visual acuity (BCVA), full-field electroretinography, and fundus autofluorescence (FAF). High-resolution images were obtained with the spectral domain optical coherence tomography (SD-OCT) and adaptive optics (AO).ResultsSD-OCT showed prominent outer retinal layer loss and outer retinal tubulations at the margin of outer retinal loss. AO images displayed prominent macrotubules and microtubules with characteristic features in eight out of the 10 eyes. Crystals were present in all ten eyes. There was a reduction in the cone count in all eyes in the area outside the outer retinal tubules (ORT).ConclusionsThis study describes the morphology of the outer retinal tubules when imaged enface on the adaptive optics in patients with BCD. These findings provide insight into the macular structure of these patients. This may have prognostic implications and refine the study on the pathogenesis of BCD.


Assuntos
Distrofias Hereditárias da Córnea/diagnóstico por imagem , Neuroglia/patologia , Imagem Óptica , Células Fotorreceptoras de Vertebrados/patologia , Doenças Retinianas/diagnóstico por imagem , Células Ganglionares da Retina/patologia , Adulto , Distrofias Hereditárias da Córnea/patologia , Eletrorretinografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Retinianas/patologia , Tomografia de Coerência Óptica , Acuidade Visual/fisiologia , Adulto Jovem
18.
BMJ Case Rep ; 20152015 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-25952974

RESUMO

A 24-year-old man presented with New York Heart Association (NYHA) grade 3 dyspnoea. He appeared dwarf-like with coarse facial features. General examination revealed cubitus valgus, claw hand, genu valgus, hallus valgus and equinovarus deformity of the foot. Systemic examination revealed cardiomegaly, a pansystolic mitral regurgitation (MR) murmur, hepatosplenomegaly and a normal IQ. Examination suggested multisystem disease involving the dermatological, musculoskeletal, cardiac and gastrointestinal system. Echocardiography showed thickened mitral and aortic valves, and moderate MR. We considered this as a storage disorder, particularly the mucopolysaccharidosis, because of its typical cardiac involvement. Further evaluation confirmed the diagnosis of Hunter syndrome. The patient was considered for enzyme replacement therapy, following which he improved. This rare disease must be considered whenever a physician encounters a young patient with multisystem involvement. In view of the availability of disease-specific therapy, an early diagnosis and prompt treatment with a multidisciplinary approach can improve the quality of life of these patients.


Assuntos
Anormalidades Múltiplas , Cardiomegalia/etiologia , Valvas Cardíacas/patologia , Mucopolissacaridose II/diagnóstico , Adulto , Ecocardiografia , Terapia de Reposição de Enzimas , Humanos , Masculino , Mucopolissacaridose II/tratamento farmacológico , Mucopolissacaridose II/patologia , Doenças Raras , Cardiopatia Reumática/patologia , Adulto Jovem
19.
Bone Joint J ; 97-B(2): 277-82, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25628295

RESUMO

Little information is available about several important aspects of the treatment of melioidosis osteomyelitis and septic arthritis. We undertook a retrospective review of 50 patients with these conditions in an attempt to determine the effect of location of the disease, type of surgical intervention and duration of antibiotic treatment on outcome, particularly complications and relapse. We found that there was a 27.5% risk of osteomyelitis of the adjacent bone in patients with septic arthritis in the lower limb. Patients with septic arthritis and osteomyelitis of an adjacent bone were in hospital significantly longer (p = 0.001), needed more operations (p = 0.031) and had a significantly higher rate of complications and re-presentation (p = 0.048). More than half the patients (61%), most particularly those with multifocal bone and joint involvement, and those with septic arthritis and osteomyelitis of an adjacent bone who were treated operatively, needed more visits to theatre.


Assuntos
Artrite Infecciosa/microbiologia , Artrite Infecciosa/cirurgia , Melioidose/cirurgia , Osteomielite/microbiologia , Osteomielite/cirurgia , Adulto , Antibacterianos/administração & dosagem , Artrite Infecciosa/tratamento farmacológico , Artrite Infecciosa/epidemiologia , Terapia Combinada , Comorbidade , Feminino , Humanos , Masculino , Melioidose/tratamento farmacológico , Melioidose/epidemiologia , Pessoa de Meia-Idade , Osteomielite/tratamento farmacológico , Osteomielite/epidemiologia
20.
J Indian Soc Pedod Prev Dent ; 33(1): 48-52, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25572374

RESUMO

BACKGROUND: Dental anxiety assessment for young children is as important as performing their treatment. Appropriate knowledge of patient's anxiety boosts confidence and will help us to review potential management options specific to every child. AIM: This study aimed to validate (RMS) Pictorial Scale (RMS-PS) and to compare it with Venham Picture Test (VPT) and Facial image scale (FIS) in measuring dental anxiety for young children during their first dental visit. MATERIALS AND METHODS: A total of 102 healthy children aged between 4 and 14 years during their first dental visit were randomly selected for the study. Childs anxiety level was measured using three different scales namely (i) RMS-PS (ii) VPT, and (iii) FIS. STATISTICAL ANALYSIS: Student t test was used to compare the scores obtained from all the three scales. Pearson correlation test was used to obtain correlation among the scales used in the study. RESULTS: A strong correlation (0·76) was found between the VPT and RMS-PS, and a moderate correlation (0.5) was found between RMS-PS and FIS, indicating good validity for the RMS-PS. CONCLUSIONS: The findings of this study suggest that the RMS-PS can be a newer and easiest means for the assessment of dental anxiety for young children in a clinical context.


Assuntos
Ansiedade ao Tratamento Odontológico/diagnóstico , Escalas de Graduação Psiquiátrica , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Psicometria
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