Fermi surface of an important nanosized metastable phase: Al3Li.

Nanoscale particles embedded in a metallic matrix are of considerable interest as a route towards identifying and tailoring material properties. Al-Li alloys, which form ordered nanoscale precipitates of Al(3)Li for a range of concentrations, have been deployed successfully in the aerospace industry owing to their superior strength-to-weight ratio. The precipitates are metastable and their electronic structure has so far been inaccessible through conventional techniques. Here, we take advantage of the strong positron affinity of Li to probe the Fermi surface of nanoscale Al(3)Li precipitates.

Anomalous electronic correlations in the ground state momentum density of Al(97)Li(3).

We report high resolution Compton scattering measurements on an Al(97)Li(3) disordered alloy single crystal for momentum transfer along the [100], [110], and [111] symmetry directions. The results are interpreted via corresponding Korringa-Kohn-Rostoker coherent potential approximation first-principles computations. By comparing spectra for Al(97)Li(3) and Al, we show that the momentum density in the alloy differs significantly from the predictions of the conventional Fermi-liquid picture and that the ground state of Al is modified anomalously by the addition of Li.

A new approach to measuring high-resolution magnetic Compton profiles.

It is demonstrated that long-term stability in the polarization of incident photons delivered from an insertion device makes it possible to measure magnetic Compton profiles with a momentum resolution of 0.15 atomic units or better, without employing a solid-state detector and the traditional method of reversing the external magnetic field or the handedness of the polarization of incident photons in an asynchronous cycle with a short period of tens to hundreds of seconds.

[Single dose intravenous toxicity studies of T-3762, a novel parenteral quinolone antimicrobial agent, in rats, dogs and monkeys].

Single dose intravenous toxicity studies of T-3762, a novel parenteral quinolone antimicrobial agent, were conducted in rats, dogs and monkeys. The following results were obtained. 1. In the rat study, all males and females given 260 mg/kg survived and all males and 3 of 5 females given 391 mg/kg died. Approximate lethal doses in male and female rats were between 260 and 391 mg/kg. In survived animals, decrease in locomotor activity and irregular respiration were observed. These clinical signs were recovered within 1 hour after dosing. In female rats given 260 mg/kg, no abnormalities were observed in general signs. In dead animals, decrease in locomotor activity, irregular respiration, staggering gait and tonic convulsion were observed and died within about 90 minutes after dosing. Macroscopic examinations in dead animals showed dark red discoloration in lung and had white foamy liquid in trachea. In histopathological examinations of dead animals, congestion, hemorrhage and edema were observed in lung. 2. In the dog study, 2 animals given 260 mg/kg survived and 2 animals given 521 mg/kg died. Approximate lethal dose in dogs was between 260 and 521 mg/kg. In the 260 and 521 mg/kg groups, decrease in locomotor activity, lateral position, vomiting, salivation and decrease in body temperature were observed. In the 521 mg/kg group, one animal died at 4 minutes and another 7 days after dosing. Histopathological examinations in 2 dead animals showed congestion or hemorrhage in heart, lung, liver, kidney, spleen and digestive tract. Erosion and necrosis at cartilage layer and cluster of chondrocyte were observed in scapular fossa and head of humerus in the 260 and 561 mg/kg groups. 3. In the monkey study, 2 animals given 260 mg/kg survived and 2 animals given 520 mg/kg died. Approximate lethal dose in monkeys was between 260 and 520 mg/kg. In the 260 mg/kg group, soft feces was observed. In the 520 mg/kg group, paleness mucosa of oral cavity, muscle weakness, mydriasis and dyspnea were observed and animals died within 4 minutes after dosing. Macroscopic and histopathological examinations in 2 dead animals showed congestion in lung, liver and kidney.

Distribution of oocysts, sporocysts and sporozoites of Eimeria tenella and Eimeria maxima in the digestive tract of chicken.

The distribution of oocysts, sporocysts and sporozoites of Eimeria tenella and Eimeria maxima in the digestive tract of chicken and in excreta was investigated. At 1 h after the oral inoculation of E. tenella oocysts, the number of sporocysts in the cecum was 3.4 x 10(6) and decreased gradually thereafter, and the number of sporozoites in the cecum increased and remained at a high level until 12 h after the inoculation. Small numbers of sporocysts and sporozoites of E. tenella were found in other intestinal sites. A great number of E. maxima sporozoites was found, especially in the jejunum, 2 h after the inoculation. The findings that the largest populations of sporozoites of E. tenella and E. maxima were found in the cecum and the jejunum, respectively, indicate that the site specificity of sporozoite invasion for each species is determined before the invasion takes place.

A case of acute myelomonocytic leukemia with subconjunctival tumor.

A subconjunctival tumor in a 29-year-old woman with acute myelomonocytic leukemia was reported. The tumor was located in the bulbar conjunctiva of her left eye, with vasodilatation and slight elevation. The pathological examination of the tumor revealed infiltration by myelomonocytic leukemia cells. The patient developed numerous skin tumors simultaneously with the conjunctival tumor and died two months thereafter despite intensive reinduction chemotherapy. The clinical course of the patient suggested that subconjunctival tumor is a clinically important sign of acute relapse in myelomonocytic leukemia.

[Electron microscopic study of the iris and bulbar conjunctiva of Werner's syndrome].

We observed the iris and the upper limbal conjunctiva from the two cases of Werner's syndrome by transmission electron microscopy. Numerous microfibrils were seen between the iris pigment epithelium and the dilator muscle, and within the stroma of the conjunctiva in both patients' eyes. These similar findings in the irides of both patients suggested the relationship between the microfibrils and Werner's syndrome. Many melanosome complexes were found in iris melanocytes, and the basement membrane of the iris vessels showed marked thickening. These findings seemed to be the changes caused by aging in cases of Werner's syndrome.

Morphological features of iris fibroblasts in dilator muscle region.

Morphological features of iris fibroblasts in the dilator muscle region of the Japanese monkey iris were demonstrated by transmission and scanning electron microscopy. The iris fibroblasts in the dilator muscle region formed the boundary between the dilator muscle and the iris stroma. These iris fibroblasts were characteristically accompanied by numerous naked axonal varicosities containing synaptic vesicles on the dilator muscle side. When viewed by scanning electron microscopy, the stromal surface of the dilator muscle layer was incompletely covered by a single layer of iris fibroblasts. From the present morphological evidence, it is suggested that iris fibroblasts in the dilator muscle region play some role in the innervation of the dilator muscle.