The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia.

Improved survival of patients with acute lymphoblastic leukemia (ALL) has emerged from identifying new prognostic markers; however, 20% of children still suffer recurrence. Previously, the altered expression of Fat1 cadherin has been implicated in a number of solid tumors. In this report, in vitro analysis shows that Fat1 protein is expressed by a range of leukemia cell lines, but not by normal peripheral blood (PB) and bone marrow (BM) cells from healthy donors. In silico analysis of expression of array data from clinical leukemias found significant levels of Fat1 transcript in 11% of acute myeloid leukemia, 29% and 63% of ALL of B and T lineages, respectively, and little or no transcript present in normal PB or BM. Furthermore, in two independent studies of matched diagnosis-relapse of precursor B-cell (preB) ALL pediatric samples (n=32 and n=27), the level of Fat1 mRNA expression was prognostic at the time of diagnosis. High Fat1 mRNA expression was predictive of shorter relapse-free and overall survival, independent of other traditional prognostic markers, including white blood cell count, sex and age. The data presented demonstrate that Fat1 expression in preB-ALL has a role in the emergence of relapse and could provide a suitable therapeutic target in high-risk preB-ALL.

Socialization of children's emotion regulation in mother-child dyads: a developmental psychopathology perspective.

This study investigated the socialization of children's emotion regulation in 25 physically maltreating and 25 nonmaltreating mother-child dyads. Maltreating mothers and their 6- to 12-year-old children were recruited from two parenting programs affiliated with Children's Protective Services with a control group matched on race, SES, child gender, and child age. Children and their mothers were interviewed individually about their (a) management of emotional expression. (b) strategies for coping with emotional arousal, and (c) anticipated consequences following emotional displays. Compared to controls, maltreated children expected less maternal support in response to their emotional displays, reported being less likely to display emotions to their mothers, and generated fewer effective coping strategies for anger. Maltreating mothers indicated less understanding of children's emotional displays and fewer effective strategies for helping children to cope with emotionally arousing situations than nonmaltreating mothers. Further, findings indicated that maternal socialization practices (e.g., providing support in response to children's emotional display, generating effective coping strategies for their child) mediate the relation between child maltreatment and children's regulation of emotional expression and emotional arousal. These findings suggest that children's emotion regulation strategies are influenced by their relationship with their social environment (e.g.. physically maltreating, nonmaltreating) and that the experience of a physically maltreating relationship may interfere with children's emotional development.

Reasons given by California physical therapists for not belonging to the american physical therapy association.

BACKGROUND AND PURPOSE: In 1997, only 22% of licensed physical therapists living in California were members of the American Physical Therapy Association (APTA). This 1998 study was designed to identify the reason(s) why most licensed physical therapists in California choose not to belong to their profession's national association and to examine the demographics of nonmembers. SUBJECTS: The subjects were a random sample of 400 California licensed physical therapists who were not members of APTA. METHODS: The survey instrument included a demographic questionnaire and statements for response using a 5-point Likert-type scale. Frequency distributions were calculated for responses and demographic data. Nonparametric analyses were used to determine statistical significance. Chi-square analysis was used to compare responses to statements by gender and by full-time versus part-time work status. Spearman rank correlation coefficients were used to determine any relationships between demographic data (eg, gender and work status). The Mann-Whitney U test was used to determine any differences in responses to specific representation questions by those respondents who worked in those environments. All statistical tests were 2-tailed tests conducted at the P(.05 level, unless otherwise indicated. Means, standard deviations, and ranges were used where appropriate. RESULTS: There was a 67% response rate. Eighty-nine percent of the respondents had been members of APTA. Eighty-eight percent of the respondents believed that APTA national dues were too high, and 90% thought California Chapter dues were too high. DISCUSSION AND CONCLUSION: Cost was the primary reason given for APTA nonmembership in California.

Emotional understanding: a comparison of physically maltreating and nonmaltreating mother-child dyads.

Investigated emotional understanding in 22 physically maltreating mothers and their children and a matched control group to determine the ways in which a maltreating relationship may interfere with children's emotional development. Findings indicated that, when compared to controls, maltreating mothers were less likely to engage in discussion reflective of emotional understanding (e.g., causes and consequences of emotion) and maltreated children demonstrated lower levels of emotional understanding. Further, significant relations emerged between maternal behavior (e.g., discussion of emotion) and children's emotional understanding skills. Findings are discussed from the functionalist approach to emotional development, emphasizing the importance of social context in the development of children's emotional understanding skills. Potential clinical applications are also considered.