Management and Prognosis of Interstitial Lung Disease With Lung Cancer (ILD-LC): A Real-World Cohort From Three Medical Centers in China.

BACKGROUND AND OBJECTIVE: Interstitial lung disease with lung cancer (ILD-LC) is rare and its management has not been fully described. This study aimed to investigate the management and prognosis of ILD-LC patients in China. METHODS: The present analysis is a retrospective real-world cohort study. Clinical data of ILD-LC patients were obtained from 3 hospitals in China. The overall survival (OS) of patients was analyzed. Univariate and multivariate regression analyses were performed. RESULTS: One hundred eighty-four ILD-LC patients included were biased toward male (85.3%), smokers (75.5%), idiopathic pulmonary fibrosis (IPF) (58.2%) patients with comorbidities (67.9%) and ECOG-PS score of 1 (65.2%). Most patients were advanced peripheral non-small cell lung cancer. The initial anti-cancer regimen for ILD-LC is mainly chemotherapy, and patients with early-stage LC prefer surgery. In the anti-cancer cohort, the number of ILD-LC patients who underwent the 2nd and 3rd or more anti-cancer regimens were 78 (55.7%) and 32 (22.8%), respectively. In the non-anticancer cohort, the median OS was 3.5 months. In the early-stage cohort, the median OS was 14.2 months in the systematic therapy group; however, the median OS was not reached in the surgery group. In the advanced-stage cohort with systematic therapy, the median OS was 7.2 months. Interstitial pneumonia (IIP) and anti-angiogenesis were associated with OS in the univariate analysis, whereas anti-angiogenesis was an independent protective factor for advanced LC with ILD. CONCLUSION: Patients with ILD-LC have very poor prognosis. Appropriate anti-tumor treatment can prolong the survival time of patients who can tolerate it. Targeted therapy and immunotherapy are alternative treatments for LC patients with mild ILD. For ILD patients with advanced LC, antiangiogenic regimens significantly improve the prognosis of the disease.

Associations between screen time, physical activity, and depressive symptoms during the 2019 coronavirus disease (COVID-19) outbreak among Chinese college students

BACKGROUND@#The 2019 novel coronavirus disease (COVID-19) emerges in China, which spreads rapidly and becomes a public health emergency of international concern. Chinese government has promptly taken quarantine measures to block the transmission of the COVID-19, which may cause deleterious consequences on everyone's behaviors and psychological health. Few studies have examined the associations between behavioral and mental health in different endemic areas. This study aimed to describe screen time (ST), physical activity (PA), and depressive symptoms, as well as their associations among Chinese college students according to different epidemic areas.@*METHODS@#The study design is cross-sectional using online survey, from 4 to 12 February 2020, 14,789 college students accomplished this online study, participants who did not complete the questionnaire were excluded, and finally this study included 11,787 college students from China.@*RESULTS@#The average age of participants was 20.51 ± 1.88 years. 57.1% of the college students were male. In total, 25.9% of college students reported depression symptoms. ST > 4 h/day was positively correlated with depressive symptoms (β = 0.48, 95%CI 0.37-0.59). COVID-19ST > 1 h/day was positively correlated with depressive symptoms (β = 0.54, 95%CI 0.43-0.65), compared with COVID-19ST ≤ 0.5 h/day. Compared with PA ≥ 3 day/week, PA < 3 day/week was positively associated with depression symptoms (β = 0.01, 95%CI 0.008-0.012). Compared with low ST and high PA, there was an interaction association between high ST and low PA on depression (β = 0.31, 95%CI 0.26-0.36). Compared with low COVID-19ST and high PA, there was an interaction association between high COVID-19ST and low PA on depression (β = 0.37, 95%CI 0.32-0.43). There were also current residence areas differences.@*CONCLUSIONS@#Our findings identified that high ST or low PA was positively associated with depressive symptoms independently, and there was also an interactive effect between ST and PA on depressive symptoms.

Epidemiological survey of invasive pulmonary fungal infection among lung transplant recipients in southern China / 中华器官移植杂志

Objective:To explore the incidence, clinical characteristics and prognosis of invasive pulmonary fungal infection(IPFI)in recipients of lung transplantation(LT)in southern China.Methods:From January 2003 to August 2019, retrospective analysis was performed for 300 recipients of lung transplantation at three hospitals in southern China. There were 254 males and 46 females with an average age of (54.98±14.2)years. Clinical data were collected from medical records, including symptoms and signs, imaging studies, bronchoscopy examination, pathogen separation and culture from deep sputum and bronchoalveolar lavage fluid(BALF), fungal-related laboratory tests and tissue pathology.Results:Among 300 cases, 93(31.0%)had at least one episode of IPFI. The most common pathogen was aspergillosis(60.2%), followed by candida(15 cases, 16.1%)and Pneumocystis jeroveci (13 cases, 14.0%). Kaplan Meier analysis indicated that all-cause mortality was significantly higher in IPFI group than that in non-IPFI(nIPFI)group with one-year mortality of 45.2% vs. 26.7% in IPFI and nIPFI groups respectively( P<0.05). Conclusions:IPFI is prevalent after LT in southern China. And aspergillosis is the most common pathogen and Candida comes the next. The median occurring time for aspergillosis is 6 months after LT. Candida infection occurs earlier at airway anastomosis. A higher incidence of invasive fungal disease(IFD)associated with a lower survival indicates that IPFI has a substantial mortality among recipients after LT. Prophylactic agents should be optimized based upon an epidemiologically likely pathogen.

Evaluation of recombinant nucleocapsid and spike proteins for serological diagnosis of novel coronavirus disease 2019 (COVID-19)

BackgroundThe colloidal gold immunochromatography assay (GICA) is a rapid diagnostic tool for novel coronavirus disease 2019 (COVID-19) infections. However, with significant numbers of false negatives, improvements to GICA are needed. MethodsSix recombinant HCoV-19 nucleocapsid and spike proteins were prepared and evaluated. The optimal proteins were employed to develop a sandwich-format GICA strip to detect total antibodies (IgM and IgG) against HCoV-19. GICAs performance was assessed with comparison of viral RNA detection. ResultsRecombinant HCoV-19 proteins were obtained, including three prokaryotically expressed rN, rN1, rN2 nucleocapsid proteins, and three eukaryotically expressed rS1, rS-RBD, rS-RBD-mFc spike proteins. The recombinant proteins with the highest ELISA titers (rS1 and rS-RBD-mFc) against coronavirus-specific IgM and IgG were chosen for GICA development. The GICA has a sensitivity and specificity of 86.89% (106/122) and 99.39% (656/660), respectively. Furthermore, 65.63% (21/32) of the clinically confirmed but RT-PCR negative samples were GICA positive. ConclusionsThe eukaryotically-expressed spike proteins (rS1and rS-RBD-mFc) are more suitable than the prokaryotically expressed nucleocapsid proteins for HCoV-19 serological diagnosis. The GICA sandwich used to detect total antibodies is a powerful complement to the current standard RNA-based tests.

Use of Hybrid Stent in Management of Complex Malignant Airway Stenosisand Fistulas / 中国肺癌杂志

BACKGROUND@#Airway stents has been widely used in airway stenosis and fistula, yet clinical date of airway stents in reestablishment a complex airway is insufficient. The aim of this study is to evaluate the efficacy and safety to combine the silicon stent and the metal stent in reestablishment a complex malignant airway.@*METHODS@#Patients with non-operable complex malignant airway stenosis and fistula were recruited in this study. Silicon Y stent combined with covered metal stent (Hybrid stent) were inserted to reestablishment the airway. Clinical outcomes and complications were observed over six months.@*RESULTS@#A total of 23 silicon Y stents and 25 covered metal stents were inserted in 23 patients. Nineteen of 23 (19/23, 82.6%) patients felt a immediately relieving of current symptoms. The mean duration of stents placement in patients was (153.43±9.14) days. The modified British Medical Research Council, Karnofsky Performance Status and Performance Status scale were improved significantly after stenting. A total of 12 patients living with stent at 6 months. Others dead of tumor progression. There were no death or immediate complications related to hybrid stenting implication.@*CONCLUSIONS@#Hybrid stenting proved to be useful and was well-tolerated in the management of complex malignant airway stenosis and fistula.

Investigation on perceived discrimination and its influencing factors among people living with HIV/AIDS / 重庆医学

Objective To investigate the perceived discrimination and its influencing factors among people living with HIV/AIDS (PLWHA).Methods PLWHA subjects met the criteria and treated in the Second Hospital of Nanjing were enrolled in this study.Self-designed questionnaire was adapted to investigate PL-WHA subjects for sociodemographic data,and the perceived discrimination was investigated via the the modified HIV stigma scale-revision scale.Results A total of 465 PLWHA subjects were investigated,the average age was (37.22±12.01) years old,and most of them were male (95.1％).50.3％ of the PLWHA subjects were homosexual,24.5％ of them were bisexual/unsure.The average score of perceived discrimination was (81.25±12.69) points,25.2％ (117 cases) of the PLWHA subjects had high level of perceived discrimination (≥88 points),74.8％ (348 cases) of them had low level of perceived discrimination (＜88 points).The multi-ple regression analysis showed that marital status,sexual orientation,social support and self-esteem were influencing factors for perceived discrimination.Conclusion Perceived discrimination commonly exists in PL-WHA subjects,and is influenced by many social and psychological factors.

Multilevel model for influencing factors of the selection of first diagnosed agencies among residents reporting illness within two weeks in Hubei Province / 重庆医学

Objective To explore the selection of medical unit and the major influencing factors among residents in Hubei province,to allocate reasonably the health resources and provide reference for developing medical policy.Methods With the method of multi-stage stratified cluster sampling,household survey were done.The multilevel statistical model was used to analyze the influencing factors of the first diagnosed agencies.Results The proportions of residents who chose primary medical institutions as the first diagnosed agencies were 64.5％ in urban areas and 84.3％ in rural areas,and the visiting rate decreased as the level of health care institutions increased.The selection of first diagnosed agencies among patients were related to district (city or village,OR=0.463,95％CI..0.254-0.842),age (OR=1.023,95％CI:1.010-1.036),the educational attainment (OR＞1.000),illness duration in days (OR=0.945,95％CI:0.917-0.973) and number of days in bed (OR=0.854,95 ％ CI:0.825-0.884).Conclusion The residents who chose primary medical institutions as the first diagnosed agencies took a large proportion.District,age,the educational attainment and the illness duration in days had influence on the selection of the first diagnosed agencies among residents.

Effects of empathy of oncology nurses on psychological distress and benefit finding in breast cancer patients / 中华行为医学与脑科学杂志

Objective To verify the influence of oncology nurses'empathy on the psychological dis-tress and benefit finding in breast cancer patients. Methods 30 oncology nurses were selected by random sampling and their empathy scores were measured with the interpersonal reactivity index (IRI-C).And they were divided into three groups based on empathy scores. 12 breast cancer patients from each primary nurse were selected by random sampling.Their psychological distress and benefit finding were measured by distress thermometer (DT) and benefit finding scale (BFS).Variance analysis was used to compare psychological distress and benefit finding among patients in different groups. The effect of nurse empathy on patients psy-chological distress and benefit finding was measured by Spearman correlation analysis and logistic regression. Results The empathy score of nurses was (44.87±17.23).The difference of empathy score in the three groups of nurses was statistically significant (F=55.941,P<0.01).There was no significant difference in psy-chological distress (low-score group:5.0(4.0,6.0),middle-score group:5.0(4.0,6.0),high-score group:5.0 (4.0,6.0)) and benefit finding (low-score group:47.5(42.0,52.8),middle-score group:48.0(43.0,54.0), high-score group:46.0(42.0,52.0)) in the three groups of patients at admission(P>0.05),while at dis-charge,the psychological distress of the patients in the high-score nurse group was lower than that of the low-score nurse group (P<0.01),and the benefit was higher than that of the low-score group (P<0.01).There was a negative correlation between the nurses'empathy abilities and patients'psychological distress ( r=-0.470, P<0.01) ,and a positive correlation between the nurses'empathy abilities with the patients'benefit finding ( r=0.521,P<0.01).When controlling for other variables,patients in nurse group with higher empathy scores would result in lower psychological distress(95％CI=0.042-0.397) and higher benefit finding (95％CI=0. 095-0.554) than patients in nurse group with lower empathy scores.Conclusion Oncology nurses'empathy effect breast cancer patients'psychological distress and benefit finding.Nurses should enhance their empathy further.

Worry about ill consequences in cancer patients and its relationship with depression / 重庆医学

Objective To understand the worry situation about ill consequences in cancer patients and its relationship with depression.Methods The inpatients with cancer were extracted from 4 general hospitals of Wuhan and Beijing city by the cluster sampling.The self-designed questionnaires were adopted to survey the worry situation about ill consequences in cancer patients.The self-rating depression scale (SDS) was used to assess the patients' depression status.Results A total of 485 cancer patients were surveyed,including 204 males (42.1 ％),281 females(57.9 ％),and the mean age was (56.59 ± 11.19)years old.More than half of the patients usually or always worried about medical expenses.Worries about not taking care of their children,losing their lives,physical disability,leaving sequela and losing life ability also happened a lot.Patients worried more about losing their life,the possibility appearing depression was greater (P＜0.05).The younger the patients were,the greater the depression possibility was;the company staffs had lower risk of depression compared with those whose occupation was others (P＜0.05).Conclusion Cancer patients have different degrees of worries about ill consequences such as medical expenses,not taking care of their children and losing their lives and their worries about losing their lives could affect their depression status.

Clinical analysis of 36 cases of advanced non-small cell lung cancer (NSCLC) with performance status (PS) scores between 2 and 4 / 中华肿瘤杂志

Objective@#To analyze the treatment of advanced non-small cell lung cancer (NSCLC) with performance status (PS) scores between 2 and 4, in order to improve the diagnosis and treatment of these patients.@*Methods@#A total of 36 patients with advanced NSCLC with hypoxemia were reviewed. The clinical data of disease characteristics, etiology, complications, manifestation, therapy, progression, and secondary biopsy were collected. The clinical efficacy was graded according to the Response Evaluation Criteria In Solid Tumors (RECIST): complete response (CR), partial response (PR), stable disease (SD) and disease progression (PD).@*Results@#All patients had hypoxemia, of whom 86.1% (31 patients) had complications and 55.6% (20 patients) had noninvasive ventilator for respiratory support. 77.8% (28 cases) received broad-spectrum antibiotic treatment, and 78.6% of them got lung osmotic relief after the anti-infection treatment. 15 cases received bedside fiberoptic bronchoscopy suction, of whom two cases were treated with airway stent deposition due to airway obstruction, four cases with thoracic drainage, four cases with anticoagulation, and one with thrombolytic therapy. After these supportive treatment, the PS score of these patients decreased from 3.4±0.5 to 2.5±0.7, while SPO2 improved from (89.0±5.2)% to (95.0±3.5)%. As first-ling anti-cancer treatment, nine patients were administrated with targeted medicine orally, 13 patients with a combined chemotherapy of pemetrexed plus bevacizumab or carboplatin, eight patients with paclitaxel plus carboplatin, four patients with gemcitabine plus carboplatin, and two patients with docetaxel plus gemcitabine. In the first response evaluation, there were one case of CR, 23 cases of PR, four cases of SD, and eight cases of PD, with a clinical benefit rate of 66.7% and a disease control rate of 77.8%. A total of 22 patients experienced disease progression, of whom eight cases had a secondary biopsy and six cases had gene sequencing. Of these 36 patients, 10 (27.8%) patients survived at the last follow-up, with a progression-free survival of (10.0±6.5) months.@*Conclusion@#Besides prompt anti-cancer treatment and best supportive treatment should be incorporated to improve PS and improve outcome.

Prevalence and distribution characteristics of symptoms of anorectal disease in Chinese residents / 重庆医学

Objective To understand the prevalence and distribution characteristics of symptoms of anorectal diseases in Chinese residents(older than 18) as to provide reference for prevention,care and treatment of anorectal diseases.Methods Stratified sampling was used according to the economic level in every province in the country,and each province selected two cities.Face-toface interviews were used to collect data in 68 906 interviewers and SPSS 17.0 was performed to analyze the data.Results Of 68 906 respondents,25 634 (37.20 ％) reported to suffer from at least one symptoms of anorectal diseases.The prevalence of the top 5 main symptoms of anorectal diseases were prolapse of anus neoplasms(14.55％),anal sore(16.53％),anal pendant expansion (14.98 ％),perianal abscess (5.88 ％),hematochezia (22.52 ％).Each symptom frequency difference was statistically significant (x2=7 727.6,P＜0.001).Populations which proned to suffer from symptoms of anorectal disease had the following characteristics:living in city,male,ageing 25-54 years old,having specialist qualifications,lacking of physical.Conclusion The prevalence of symptoms of anorectal diseases among Chinese residents was high,and each symptom had its distribution characteristics.More targeted interventions should be taken in anorectal disease prone people.

Worry about ill consequences in cancer patients and its relationship with depression / 重庆医学

Objective To understand the worry situation about ill consequences in cancer patients and its relationship with depression.Methods The inpatients with cancer were extracted from 4 general hospitals of Wuhan and Beijing city by the cluster sampling.The self-designed questionnaires were adopted to survey the worry situation about ill consequences in cancer patients.The self-rating depression scale (SDS) was used to assess the patients' depression status.Results A total of 485 cancer patients were surveyed,including 204 males (42.1 ％),281 females(57.9 ％),and the mean age was (56.59 ± 11.19)years old.More than half of the patients usually or always worried about medical expenses.Worries about not taking care of their children,losing their lives,physical disability,leaving sequela and losing life ability also happened a lot.Patients worried more about losing their life,the possibility appearing depression was greater (P＜0.05).The younger the patients were,the greater the depression possibility was;the company staffs had lower risk of depression compared with those whose occupation was others (P＜0.05).Conclusion Cancer patients have different degrees of worries about ill consequences such as medical expenses,not taking care of their children and losing their lives and their worries about losing their lives could affect their depression status.

One-night-stand behavior and associated factors among young men who have sex with men in Wuhan, China / 中华流行病学杂志

Objective This present study was to examine the prevalence and determinants of one-night-stand behavior among young men who have sex with men (YMSM).Methods A total of 403 YMSM aged 16 to 25 were recruited through internet promotion,extending activity and HIV VCT in Wuhan.Data was gathered through anonymous questionnaire.Binary logistic regression was used to examine factors associated with one-night-stand behavior.Results Of the 398 YMSM,48.99％ (195/ 398) reported having had casual sex in the last 6 months.Of the ones having had casual sex,34.29％ (60/175) and 28.65％ (49/171) reported using condoms consistently during anal or oral sexual contacts,respectively.These figures were lower than those of YMSM not having casual sexual contacts [with anal sex as 49.08％ (80/163) and oral sex as 38.85％ (61/157)].76.80％ (149/194) of the YMSM reported having had multiple sexual partners,with the figure higher than those without [33.15％ (60/ 181)] (P＜0.01).Results from the logistic regression analysis showed that the following factors seemed to be associated with casual sex activities among YMSM,including:often using intemet,(OR=4.89,95％ CI:1.90-12.54),taking illegal drugs (OR=2.72,95％ CI:1.60-4.63).Conclusions YMSM who bad engaged in casual sex,practicing unprotected sex or having multiple sexual partners,were recognized as high risk population.Targeted intervention programs are needed to decrease the one-night-stand behavior.Internct intervention strategy seemed an important method to serve the purpose.

Spatial and temporal characteristics of HIV/AIDS in Hubei province, 2010-2013 / 中华流行病学杂志

Objective To understand the spatial and temporal distribution of HIV/AIDS in Hubei province,and provide scientific evidence for the prevention and control of AIDS.Methods GeoDa software was used for autocorrelation analysis,SatScan 9.2 software was used for statistical analysis of spatial scanning,and finally geographic information system was used for visualization.Results A total of 6 952 HIV/AIDS cases were reported during 2010-2013 in Hubei,and the spatial autocorrelation analysis showed that Global Moran's I index was 0.266 (P＜0.05),indicating that there was a positive spatial autocorrelation of HIV/AIDS.Global Moran's I index increased year by year (P＜ 0.05),indicating that the increased spatial aggregation of HIV/AIDS during 2010-2013.The local Moran's I index showed that "high-high" clustering areas were in Wuhan,and the number of "high-high" clustering areas increased during 2010-2013.Moreover,the "high-high" clustering areas expanded from Wuhan to surrounding areas.Spatial and temporal scan analysis revealed that 19 counties in Wuhan,Huangshi,Ezhou,Xianning with a radius of 60.01 km (LLR=625.14,RR=3.23) were the main spatial and temporal clustering area during 2012-2013.Conclusion The spatial changes of HIV/AIDS seemed to be regular from 2010 to 2013 in Wuhan,spatial correlation at provincial level decreased and the "high-high" clustering areas gradually expanded from Wuhan to surrounding areas,indicating that it is necessary to strengthen the AIDS prevention and control in these areas in Hubei.

One-night-stand behavior and associated factors among young men who have sex with men in Wuhan, China / 中华流行病学杂志

Objective This present study was to examine the prevalence and determinants of one-night-stand behavior among young men who have sex with men (YMSM).Methods A total of 403 YMSM aged 16 to 25 were recruited through internet promotion,extending activity and HIV VCT in Wuhan.Data was gathered through anonymous questionnaire.Binary logistic regression was used to examine factors associated with one-night-stand behavior.Results Of the 398 YMSM,48.99％ (195/ 398) reported having had casual sex in the last 6 months.Of the ones having had casual sex,34.29％ (60/175) and 28.65％ (49/171) reported using condoms consistently during anal or oral sexual contacts,respectively.These figures were lower than those of YMSM not having casual sexual contacts [with anal sex as 49.08％ (80/163) and oral sex as 38.85％ (61/157)].76.80％ (149/194) of the YMSM reported having had multiple sexual partners,with the figure higher than those without [33.15％ (60/ 181)] (P＜0.01).Results from the logistic regression analysis showed that the following factors seemed to be associated with casual sex activities among YMSM,including:often using intemet,(OR=4.89,95％ CI:1.90-12.54),taking illegal drugs (OR=2.72,95％ CI:1.60-4.63).Conclusions YMSM who bad engaged in casual sex,practicing unprotected sex or having multiple sexual partners,were recognized as high risk population.Targeted intervention programs are needed to decrease the one-night-stand behavior.Internct intervention strategy seemed an important method to serve the purpose.

Spatial and temporal characteristics of HIV/AIDS in Hubei province, 2010-2013 / 中华流行病学杂志

Objective To understand the spatial and temporal distribution of HIV/AIDS in Hubei province,and provide scientific evidence for the prevention and control of AIDS.Methods GeoDa software was used for autocorrelation analysis,SatScan 9.2 software was used for statistical analysis of spatial scanning,and finally geographic information system was used for visualization.Results A total of 6 952 HIV/AIDS cases were reported during 2010-2013 in Hubei,and the spatial autocorrelation analysis showed that Global Moran's I index was 0.266 (P＜0.05),indicating that there was a positive spatial autocorrelation of HIV/AIDS.Global Moran's I index increased year by year (P＜ 0.05),indicating that the increased spatial aggregation of HIV/AIDS during 2010-2013.The local Moran's I index showed that "high-high" clustering areas were in Wuhan,and the number of "high-high" clustering areas increased during 2010-2013.Moreover,the "high-high" clustering areas expanded from Wuhan to surrounding areas.Spatial and temporal scan analysis revealed that 19 counties in Wuhan,Huangshi,Ezhou,Xianning with a radius of 60.01 km (LLR=625.14,RR=3.23) were the main spatial and temporal clustering area during 2012-2013.Conclusion The spatial changes of HIV/AIDS seemed to be regular from 2010 to 2013 in Wuhan,spatial correlation at provincial level decreased and the "high-high" clustering areas gradually expanded from Wuhan to surrounding areas,indicating that it is necessary to strengthen the AIDS prevention and control in these areas in Hubei.

The prevalence rate and influential factors of diabetes among residents aged over 15 in Hubei Province / 重庆医学

Objective To study the prevalence rate and influential factors of diabetes among residents aged over 15 in Hubei province to provide evidences for diabetes control .Methods Through stratified cluster sampling ,20 cities and counties ,including 100 blocks and towns ,200 communities and villages were sampled .Household survey was carried out from October to November , 2013 .Data was analyzed with SPSS18 .0 .Results In total ,28 555 eligible residents were surveyed ,among which 823 (2 .88% ) self‐reported being diagnosed as diabetes .The prevalence rate for urban and rural residents were found as 4 .37% and 1 .83% respective‐ly ,that of male and female as 2 .61% and 3 .13% respectively .Residents aged 65 and above reported highest prevalence rate (6 .61% ) while those from 25 to 34 years old had the lowest (0 .06% ) .Multiple logistic regression analysis yielded results that ru‐ral‐urban residence ,age ,occupational status ,type of medical insurance ,alcohol drinking and obesity were influential factors of diabe‐tes .Conclusion Prevalence rate of diabetes among residents aged over 15 in Hubei province was at a relatively lower level and there were differences between population subgroups .

Analysis on prevalence situation of hypertension among residents aged 15 years old or more in Hubei Province / 重庆医学

Objective To understand the hypertension prevalence situation and its associated factors among residents in Hu‐bei Province to provide a reference basis for preventing and controlling residents′ hypertension .Methods The residents aged 15 years old or more were sampled from 20 counties (cities and districts) by adopting the multi‐staged stratified cluster sampling .The unified questionnaire was adopted to conduct the face to face interview by entering home .The multivariate Logistic regression was used to analyze the influencing factors of hypertension .Results A total of 28 555 respondents were investigated ,4 135 respondents reported hypertension and the hypertension prevalence rate was 14 .48% .The hypertension prevalence rate in urban residents was 18 .41% ,which was higher than 11 .71% in rural residents(P0 .05) .The multivariate Logistic regression results revealed that the risk of hypertension was increased with age ;compared with job‐hololers ,the retired(OR=1 .44 , 95% CI:1 .25-1 .65)and the unemployed(OR=1 .29 ,95% CI:1 .15-1 .46)had more possibility to suffer from hypertension ;higher income earners had lower risk of hypertension ;obese people(OR=3 .09 ,95% CI:2 .63~3 .63)and diabetes(OR= 3 .87 ,95% CI:3 .30-4 .52)were more likely to suffer from hypertension .Conclusion The prevalence rate of hypertension among residents aged 15 years old or more in Hubei Province presents the increasing trend ,which needs the corresponding departments and institutions to adopt the measures to actively prevent and control hypertension .

Post-traumatic stress disorder among people living with HIV/AIDS and its influence factors / 重庆医学

Objective To investigate the post-traumatic stress disorder (PTSD) and its influence factors among people living with HIV /AIDS (PLWHA) ,and provide evidence for developing relevant interventions and treatment methods .Methods Anony-mously completed questionnaires ,including self-designed questionnaire and the post-traumatic checklist civilian version (PCL-C) , were received from PLWHA in Suizhou from December 2014 to March 2015 .Descriptive analysis and multivariate logistic regres-sion analysis were used to examine factors associated with PTSD .Results Among 243 qualified PLWHA ,106 of them were positive with PTSD (43 .62% ) ,and the prevalence of PTSD among male and female were 37 .88% and 50 .45% ,respectively .Among the three characteristic symptoms ,repeated flashback was the highest (78 .60% ) ,then hyper-vigilance (64 .20% ) ,and the positive rate of avoidance/numbness was the lowest (57 .20% ) .Multivariate logistic regression analysis showed that female was more suscepti-ble to PTSD than male (OR = 1 .960 ,95% CI :1 .025 - 3 .747) ,discrimination or unfair treatment would increase the risk of PTSD (OR= 2 .967 ,95% CI :1 .498 - 5 .876) ,and the frequency of fear/tension was positive correlated with PTSD (occasionally OR =2 .074 ,95% CI :1 .008 - 4 .265 ;always OR = 6 .690 ,95% CI :2 .708 - 16 .531) .Conclusion PLWHA had a high level of PTSD ,and fe-male PLWHA and those who felt fear/tension or experienced discrimination/unfair treatment were more likely to suffer from PTSD .